Coating and encapsulation of nanoparticles using supercritical antisolvent
Problem statement: Literature on the production of nanoparticles using supercritical fluids is substantial, but comparatively much less for nanoencapsulation. Approach: In this study, a modified Supercritical Anti Solvent (SAS) apparatus was fabricated for use in the production of nanoparticles usin...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Science Publications
2009
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13616/ http://psasir.upm.edu.my/id/eprint/13616/1/Coating%20and%20Encapsulation%20of%20Nanoparticles%20using%20Supercritical%20Antisolvent.pdf |
| _version_ | 1848842161354702848 |
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| author | Chong, Gun Hean Yunus, Robiah Abdullah, Norhafizah Choong, Thomas Shean Yaw Spotar, Sergey |
| author_facet | Chong, Gun Hean Yunus, Robiah Abdullah, Norhafizah Choong, Thomas Shean Yaw Spotar, Sergey |
| author_sort | Chong, Gun Hean |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Problem statement: Literature on the production of nanoparticles using supercritical fluids is substantial, but comparatively much less for nanoencapsulation. Approach: In this study, a modified Supercritical Anti Solvent (SAS) apparatus was fabricated for use in the production of nanoparticles using carbon dioxide as the supercritical fluid (SCF). SAS technique involves precipitation of solids from liquid solution under supercritical antisolvent-induced condition. Production of nanoparticles using SAS was investigated using 2 types of model solutes: Fume silica and acetaminophen which represent a model of water insoluble (inorganic) material and water soluble material respectively. The morphology and characteristics of nanoparticles produced were assessed. Results: The fume silica had been coated and 50 nm diameter of nanoencapsulated acetaminophen had been produced. Conclusion: The results had revealed that both water insoluble and soluble substrates can be coated and encapsulated successfully in polymer by the SAS coating process. |
| first_indexed | 2025-11-15T07:54:44Z |
| format | Article |
| id | upm-13616 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:54:44Z |
| publishDate | 2009 |
| publisher | Science Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-136162017-11-23T09:10:20Z http://psasir.upm.edu.my/id/eprint/13616/ Coating and encapsulation of nanoparticles using supercritical antisolvent Chong, Gun Hean Yunus, Robiah Abdullah, Norhafizah Choong, Thomas Shean Yaw Spotar, Sergey Problem statement: Literature on the production of nanoparticles using supercritical fluids is substantial, but comparatively much less for nanoencapsulation. Approach: In this study, a modified Supercritical Anti Solvent (SAS) apparatus was fabricated for use in the production of nanoparticles using carbon dioxide as the supercritical fluid (SCF). SAS technique involves precipitation of solids from liquid solution under supercritical antisolvent-induced condition. Production of nanoparticles using SAS was investigated using 2 types of model solutes: Fume silica and acetaminophen which represent a model of water insoluble (inorganic) material and water soluble material respectively. The morphology and characteristics of nanoparticles produced were assessed. Results: The fume silica had been coated and 50 nm diameter of nanoencapsulated acetaminophen had been produced. Conclusion: The results had revealed that both water insoluble and soluble substrates can be coated and encapsulated successfully in polymer by the SAS coating process. Science Publications 2009 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13616/1/Coating%20and%20Encapsulation%20of%20Nanoparticles%20using%20Supercritical%20Antisolvent.pdf Chong, Gun Hean and Yunus, Robiah and Abdullah, Norhafizah and Choong, Thomas Shean Yaw and Spotar, Sergey (2009) Coating and encapsulation of nanoparticles using supercritical antisolvent. American Journal of Applied Sciences, 6 (7). pp. 1352-1358. ISSN 1546-9239; ESSN: 1554-3641 http://www.thescipub.com/abstract/?doi=ajassp.2009.1352.1358 10.3844/ajassp.2009.1352.1358 |
| spellingShingle | Chong, Gun Hean Yunus, Robiah Abdullah, Norhafizah Choong, Thomas Shean Yaw Spotar, Sergey Coating and encapsulation of nanoparticles using supercritical antisolvent |
| title | Coating and encapsulation of nanoparticles using supercritical antisolvent |
| title_full | Coating and encapsulation of nanoparticles using supercritical antisolvent |
| title_fullStr | Coating and encapsulation of nanoparticles using supercritical antisolvent |
| title_full_unstemmed | Coating and encapsulation of nanoparticles using supercritical antisolvent |
| title_short | Coating and encapsulation of nanoparticles using supercritical antisolvent |
| title_sort | coating and encapsulation of nanoparticles using supercritical antisolvent |
| url | http://psasir.upm.edu.my/id/eprint/13616/ http://psasir.upm.edu.my/id/eprint/13616/ http://psasir.upm.edu.my/id/eprint/13616/ http://psasir.upm.edu.my/id/eprint/13616/1/Coating%20and%20Encapsulation%20of%20Nanoparticles%20using%20Supercritical%20Antisolvent.pdf |