Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum
Four new chromone alkaloids, chrotacumines A-D (1-4), consisting of a 5,7-dihydroxy-2-methylchromone, an N-Me piperidine ring, and an ester side chain were isolated from Dysoxylum acutangulum, and their structures including absolute configurations were elucidated on the basis of spectroscopic data i...
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| Format: | Article |
| Language: | English |
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American Society of Pharmacognosy & American Chemical Society
2009
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13595/ http://psasir.upm.edu.my/id/eprint/13595/1/Chrotacumines%20A.pdf |
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| author | Ismail, Intan Safinar Nagakura, Yuta Hirasawa, Yusuke Hosoya, Takahiro Mohd Lazim, Mohd Izwan Lajis, Md. Nordin Shiro, Motoo Morita, Hiroshi |
| author_facet | Ismail, Intan Safinar Nagakura, Yuta Hirasawa, Yusuke Hosoya, Takahiro Mohd Lazim, Mohd Izwan Lajis, Md. Nordin Shiro, Motoo Morita, Hiroshi |
| author_sort | Ismail, Intan Safinar |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Four new chromone alkaloids, chrotacumines A-D (1-4), consisting of a 5,7-dihydroxy-2-methylchromone, an N-Me piperidine ring, and an ester side chain were isolated from Dysoxylum acutangulum, and their structures including absolute configurations were elucidated on the basis of spectroscopic data interpretation including 2D NMR, CD spectra, and X-ray analysis. The known compound rohitukine (5) showed moderate cytotoxicity against human HL-60 promyelocytic leukemia and HCT-116 colon cancer cells. |
| first_indexed | 2025-11-15T07:54:38Z |
| format | Article |
| id | upm-13595 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:54:38Z |
| publishDate | 2009 |
| publisher | American Society of Pharmacognosy & American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-135952015-09-29T02:06:56Z http://psasir.upm.edu.my/id/eprint/13595/ Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum Ismail, Intan Safinar Nagakura, Yuta Hirasawa, Yusuke Hosoya, Takahiro Mohd Lazim, Mohd Izwan Lajis, Md. Nordin Shiro, Motoo Morita, Hiroshi Four new chromone alkaloids, chrotacumines A-D (1-4), consisting of a 5,7-dihydroxy-2-methylchromone, an N-Me piperidine ring, and an ester side chain were isolated from Dysoxylum acutangulum, and their structures including absolute configurations were elucidated on the basis of spectroscopic data interpretation including 2D NMR, CD spectra, and X-ray analysis. The known compound rohitukine (5) showed moderate cytotoxicity against human HL-60 promyelocytic leukemia and HCT-116 colon cancer cells. American Society of Pharmacognosy & American Chemical Society 2009-10 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13595/1/Chrotacumines%20A.pdf Ismail, Intan Safinar and Nagakura, Yuta and Hirasawa, Yusuke and Hosoya, Takahiro and Mohd Lazim, Mohd Izwan and Lajis, Md. Nordin and Shiro, Motoo and Morita, Hiroshi (2009) Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum. Journal of Natural Products, 72 (10). pp. 1879-1883. ISSN 0163-3864 & Online ISSN: 1520-6025 10.1021/np9003849 |
| spellingShingle | Ismail, Intan Safinar Nagakura, Yuta Hirasawa, Yusuke Hosoya, Takahiro Mohd Lazim, Mohd Izwan Lajis, Md. Nordin Shiro, Motoo Morita, Hiroshi Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum |
| title | Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum |
| title_full | Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum |
| title_fullStr | Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum |
| title_full_unstemmed | Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum |
| title_short | Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum |
| title_sort | chrotacumines a-d, chromone alkaloids from dysoxylum acutangulum |
| url | http://psasir.upm.edu.my/id/eprint/13595/ http://psasir.upm.edu.my/id/eprint/13595/ http://psasir.upm.edu.my/id/eprint/13595/1/Chrotacumines%20A.pdf |