Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors.

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Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors.

The majority of BRCA1-associated breast cancers are basal cell–like, which is associated with a poor outcome. Using a spontaneous mouse mammary tumor model, we show that platinum compounds, which generate DNA breaks during the repair process, are more effective than doxorubicin in Brca1/p53–mutated...

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Bibliographic Details
Main Authors:	Shafee, Norazizah, Smith, Christopher R., Shuanzeng, Wel, Yoo, Kim, Mills, Gordo B., Hortobagyi, Gabriel N., Stanbridge, Eric J.
Format:	Article
Language:	English
Published:	American Association for Cancer Research 2008
Online Access:	http://psasir.upm.edu.my/id/eprint/13481/

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