Biological activities of Pereskia bleo extracts
The aim of this study is to screen the hexane, dicholoromethane, ethyl acetate and methanol extracts of Pereskia bleo (PB) for their antibacterial, anti-oxidant and anti-cancer properties using disc diffusion method, DPPH assay and MTT cytotoxicity test, respectively. It is found that hexane and met...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Asian Network for Scientific Information
2009
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/13416/ http://psasir.upm.edu.my/id/eprint/13416/1/Biological%20activities%20of%20Pereskia%20bleo%20extracts.pdf |
| _version_ | 1848842106732281856 |
|---|---|
| author | Abdelwahab, Siddig Ibrahim Abdul, Ahmad Bustamam Mohan, Syam Murali Al-Zubairi, Adel Sharaf Elhassan Taha, Manal Mohamed Ibrahim, M. Y. |
| author_facet | Abdelwahab, Siddig Ibrahim Abdul, Ahmad Bustamam Mohan, Syam Murali Al-Zubairi, Adel Sharaf Elhassan Taha, Manal Mohamed Ibrahim, M. Y. |
| author_sort | Abdelwahab, Siddig Ibrahim |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The aim of this study is to screen the hexane, dicholoromethane, ethyl acetate and methanol extracts of Pereskia bleo (PB) for their antibacterial, anti-oxidant and anti-cancer properties using disc diffusion method, DPPH assay and MTT cytotoxicity test, respectively. It is found that hexane and methanol extracts showed highly and moderately, respectively, considerable antibacterial activity towards two Gram-negative bacteria, P. aeruginosa 60690 and S. choleraesuis. Ethyl acetate extract showed a week narrow spectrum activity (= 35% of streptomycin activity). The highest antibacterial activity on MRSA is obtained by DCM extract. Hexane extract was the most effective DPPH radical scavenger (37.55%). Ethyl acetate and DCM extracts were less effective free radical scavenger (16.1%). None of the extracts were cytotoxic significantly towards MCF-7, HT-29 and CEM-SS cell lines after 72 h incubation time (IC50 > 30 μg mL-1). It could be concluded that antibacterial activity of P. bleo is the most promising biological activity attributed to this plant. |
| first_indexed | 2025-11-15T07:53:52Z |
| format | Article |
| id | upm-13416 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:53:52Z |
| publishDate | 2009 |
| publisher | Asian Network for Scientific Information |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-134162015-11-19T08:52:30Z http://psasir.upm.edu.my/id/eprint/13416/ Biological activities of Pereskia bleo extracts Abdelwahab, Siddig Ibrahim Abdul, Ahmad Bustamam Mohan, Syam Murali Al-Zubairi, Adel Sharaf Elhassan Taha, Manal Mohamed Ibrahim, M. Y. The aim of this study is to screen the hexane, dicholoromethane, ethyl acetate and methanol extracts of Pereskia bleo (PB) for their antibacterial, anti-oxidant and anti-cancer properties using disc diffusion method, DPPH assay and MTT cytotoxicity test, respectively. It is found that hexane and methanol extracts showed highly and moderately, respectively, considerable antibacterial activity towards two Gram-negative bacteria, P. aeruginosa 60690 and S. choleraesuis. Ethyl acetate extract showed a week narrow spectrum activity (= 35% of streptomycin activity). The highest antibacterial activity on MRSA is obtained by DCM extract. Hexane extract was the most effective DPPH radical scavenger (37.55%). Ethyl acetate and DCM extracts were less effective free radical scavenger (16.1%). None of the extracts were cytotoxic significantly towards MCF-7, HT-29 and CEM-SS cell lines after 72 h incubation time (IC50 > 30 μg mL-1). It could be concluded that antibacterial activity of P. bleo is the most promising biological activity attributed to this plant. Asian Network for Scientific Information 2009 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13416/1/Biological%20activities%20of%20Pereskia%20bleo%20extracts.pdf Abdelwahab, Siddig Ibrahim and Abdul, Ahmad Bustamam and Mohan, Syam Murali and Al-Zubairi, Adel Sharaf and Elhassan Taha, Manal Mohamed and Ibrahim, M. Y. (2009) Biological activities of Pereskia bleo extracts. International Journal of Pharmacology, 5 (1). pp. 71-75. ISSN 1811-7775; ESSN: 1812-5700 http://scialert.net/abstract/?doi=ijp.2009.71.75 10.3923/ijp.2009.71.75 |
| spellingShingle | Abdelwahab, Siddig Ibrahim Abdul, Ahmad Bustamam Mohan, Syam Murali Al-Zubairi, Adel Sharaf Elhassan Taha, Manal Mohamed Ibrahim, M. Y. Biological activities of Pereskia bleo extracts |
| title | Biological activities of Pereskia bleo extracts |
| title_full | Biological activities of Pereskia bleo extracts |
| title_fullStr | Biological activities of Pereskia bleo extracts |
| title_full_unstemmed | Biological activities of Pereskia bleo extracts |
| title_short | Biological activities of Pereskia bleo extracts |
| title_sort | biological activities of pereskia bleo extracts |
| url | http://psasir.upm.edu.my/id/eprint/13416/ http://psasir.upm.edu.my/id/eprint/13416/ http://psasir.upm.edu.my/id/eprint/13416/ http://psasir.upm.edu.my/id/eprint/13416/1/Biological%20activities%20of%20Pereskia%20bleo%20extracts.pdf |