Association of insertion/deletion polymorphism of alpha-adrenoceptor gene in essential hypertension with or without type 2 diabetes mellitus in Malaysian subjects.
An insertion/deletion (I/D) polymorphism of Alpha2B-Adrenoceptor (ADRA2B) gene located on chromosome 2 has been studied extensively in related to cardiovascular diseases. The main aim of the present study was to examine the potential association of D allele frequency of I/D polymorphism of ADRA2B ge...
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| Format: | Article |
| Language: | English |
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Ivyspring International Publisher
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13315/ http://psasir.upm.edu.my/id/eprint/13315/1/Association%20of%20insertion%20deletion%20polymorphism%20of%20alpha%20adrenoceptor%20gene%20in%20essential%20hypertension%20with%20or%20without%20type%202%20diabetes%20mellitus%20in%20Malaysian%20subjects.pdf |
| _version_ | 1848842079482937344 |
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| author | Vasudevan, Ramachandran Ismail, Patimah Stanslas, Johnson Shamsudin, Norashikin Ali, Aisyah |
| author_facet | Vasudevan, Ramachandran Ismail, Patimah Stanslas, Johnson Shamsudin, Norashikin Ali, Aisyah |
| author_sort | Vasudevan, Ramachandran |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | An insertion/deletion (I/D) polymorphism of Alpha2B-Adrenoceptor (ADRA2B) gene located on chromosome 2 has been studied extensively in related to cardiovascular diseases. The main aim of the present study was to examine the potential association of D allele frequency of I/D polymorphism of ADRA2B gene in Malaysian essential hypertensive subjects with or without type 2 diabetes mellitus (T2DM). This study includes 70 hypertensive subjects without T2DM, 65 hypertensive subjects with T2DM and 75 healthy volunteers as control subjects. Genotyping of I/D polymorphism was performed by conventional PCR method. There was significant difference found in age, body mass index, systolic/diastolic blood pressure and high density lipoprotein cholesterol level between the case and control subjects. DD genotypic frequency of I/D polymorphism was significantly higher in hypertensive subjects (42.84% vs. 29.33%; P=0.029) and in hypertensive with T2DM subjects (46.15% vs. 29.33%; P=0.046) than control group. D allele frequency was higher in hypertensive group (67.41%) than control subjects (52.67%). However, no significant difference was found between the three genotypes of I/D polymorphism of ADRA2B gene and the clinical characteristics of the subjects. The result obtained in this study show D allele of ADRA2B gene was associated with essential hypertension with or without T2DM in Malaysian subjects. |
| first_indexed | 2025-11-15T07:53:26Z |
| format | Article |
| id | upm-13315 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:53:26Z |
| publishDate | 2008 |
| publisher | Ivyspring International Publisher |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-133152015-10-08T02:23:16Z http://psasir.upm.edu.my/id/eprint/13315/ Association of insertion/deletion polymorphism of alpha-adrenoceptor gene in essential hypertension with or without type 2 diabetes mellitus in Malaysian subjects. Vasudevan, Ramachandran Ismail, Patimah Stanslas, Johnson Shamsudin, Norashikin Ali, Aisyah An insertion/deletion (I/D) polymorphism of Alpha2B-Adrenoceptor (ADRA2B) gene located on chromosome 2 has been studied extensively in related to cardiovascular diseases. The main aim of the present study was to examine the potential association of D allele frequency of I/D polymorphism of ADRA2B gene in Malaysian essential hypertensive subjects with or without type 2 diabetes mellitus (T2DM). This study includes 70 hypertensive subjects without T2DM, 65 hypertensive subjects with T2DM and 75 healthy volunteers as control subjects. Genotyping of I/D polymorphism was performed by conventional PCR method. There was significant difference found in age, body mass index, systolic/diastolic blood pressure and high density lipoprotein cholesterol level between the case and control subjects. DD genotypic frequency of I/D polymorphism was significantly higher in hypertensive subjects (42.84% vs. 29.33%; P=0.029) and in hypertensive with T2DM subjects (46.15% vs. 29.33%; P=0.046) than control group. D allele frequency was higher in hypertensive group (67.41%) than control subjects (52.67%). However, no significant difference was found between the three genotypes of I/D polymorphism of ADRA2B gene and the clinical characteristics of the subjects. The result obtained in this study show D allele of ADRA2B gene was associated with essential hypertension with or without T2DM in Malaysian subjects. Ivyspring International Publisher 2008-10-05 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13315/1/Association%20of%20insertion%20deletion%20polymorphism%20of%20alpha%20adrenoceptor%20gene%20in%20essential%20hypertension%20with%20or%20without%20type%202%20diabetes%20mellitus%20in%20Malaysian%20subjects.pdf Vasudevan, Ramachandran and Ismail, Patimah and Stanslas, Johnson and Shamsudin, Norashikin and Ali, Aisyah (2008) Association of insertion/deletion polymorphism of alpha-adrenoceptor gene in essential hypertension with or without type 2 diabetes mellitus in Malaysian subjects. International Journal of Biological Sciences, 4 (6). pp. 362-367. ISSN 1449-2288 http://www.ijbs.com/v04p0362 10.7150/ijbs.4.362 |
| spellingShingle | Vasudevan, Ramachandran Ismail, Patimah Stanslas, Johnson Shamsudin, Norashikin Ali, Aisyah Association of insertion/deletion polymorphism of alpha-adrenoceptor gene in essential hypertension with or without type 2 diabetes mellitus in Malaysian subjects. |
| title | Association of insertion/deletion polymorphism of alpha-adrenoceptor gene in essential hypertension with or without type 2 diabetes mellitus in Malaysian subjects. |
| title_full | Association of insertion/deletion polymorphism of alpha-adrenoceptor gene in essential hypertension with or without type 2 diabetes mellitus in Malaysian subjects. |
| title_fullStr | Association of insertion/deletion polymorphism of alpha-adrenoceptor gene in essential hypertension with or without type 2 diabetes mellitus in Malaysian subjects. |
| title_full_unstemmed | Association of insertion/deletion polymorphism of alpha-adrenoceptor gene in essential hypertension with or without type 2 diabetes mellitus in Malaysian subjects. |
| title_short | Association of insertion/deletion polymorphism of alpha-adrenoceptor gene in essential hypertension with or without type 2 diabetes mellitus in Malaysian subjects. |
| title_sort | association of insertion/deletion polymorphism of alpha-adrenoceptor gene in essential hypertension with or without type 2 diabetes mellitus in malaysian subjects. |
| url | http://psasir.upm.edu.my/id/eprint/13315/ http://psasir.upm.edu.my/id/eprint/13315/ http://psasir.upm.edu.my/id/eprint/13315/ http://psasir.upm.edu.my/id/eprint/13315/1/Association%20of%20insertion%20deletion%20polymorphism%20of%20alpha%20adrenoceptor%20gene%20in%20essential%20hypertension%20with%20or%20without%20type%202%20diabetes%20mellitus%20in%20Malaysian%20subjects.pdf |