Antioxidant and hepatoprotective activities of Elephantopus tomentosus ethanol extract.
The current study evaluated the antioxidant and hepatoprotective activities of Elephantopus tomentosus L. (Asteraceae) ethanol extract (ET). In the experiment, total antioxidant capacity, reducing capacity, DPPH* and hydrogen peroxide scavenging, and Fe3 +-induced lipid peroxidation inhibiting activ...
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| Format: | Article |
| Language: | English |
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Informa Healthcare
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13185/ http://psasir.upm.edu.my/id/eprint/13185/1/Antioxidant%20and%20hepatoprotective%20activities%20of%20Elephantopus%20tomentosus%20ethanol%20extract.pdf |
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| author | Yam, Mun Fei Basir, Rusliza Asmawil, Mohd Zaini Rosidah, Ahmad, Mariam Akowuah, Gabriel Akyirem |
| author_facet | Yam, Mun Fei Basir, Rusliza Asmawil, Mohd Zaini Rosidah, Ahmad, Mariam Akowuah, Gabriel Akyirem |
| author_sort | Yam, Mun Fei |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The current study evaluated the antioxidant and hepatoprotective activities of Elephantopus tomentosus L. (Asteraceae) ethanol extract (ET). In the experiment, total antioxidant capacity, reducing capacity, DPPH* and hydrogen peroxide scavenging, and Fe3 +-induced lipid peroxidation inhibiting activities of ET were determined. The results indicated that ET exhibited antioxidant (1 mg/mL ET was equal to 2.1 mM TEAC), lipid peroxidation inhibition, hydrogen peroxide, and free radical scavenging activities. The hepatoprotective activity of ET was studied using CCl4-induced liver toxicity in rats. Oral administration of ET (500 mg/kg) significantly reduced CCl4-induced hepatotoxicity in rats, as observed from the serum level of the liver enzyme aspartate aminotransferase (AST), alanine aminotransferase (ALT), and also from the histopathologic study. The total phenolic content in the lyophilized ethanol extract is approximately 10%. The results of the current study indicated that the hepatoprotective effect of E. tomentosus might be ascribable to its antioxidant and free radical scavenging properties. |
| first_indexed | 2025-11-15T07:52:51Z |
| format | Article |
| id | upm-13185 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:52:51Z |
| publishDate | 2008 |
| publisher | Informa Healthcare |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-131852015-11-11T00:51:38Z http://psasir.upm.edu.my/id/eprint/13185/ Antioxidant and hepatoprotective activities of Elephantopus tomentosus ethanol extract. Yam, Mun Fei Basir, Rusliza Asmawil, Mohd Zaini Rosidah, Ahmad, Mariam Akowuah, Gabriel Akyirem The current study evaluated the antioxidant and hepatoprotective activities of Elephantopus tomentosus L. (Asteraceae) ethanol extract (ET). In the experiment, total antioxidant capacity, reducing capacity, DPPH* and hydrogen peroxide scavenging, and Fe3 +-induced lipid peroxidation inhibiting activities of ET were determined. The results indicated that ET exhibited antioxidant (1 mg/mL ET was equal to 2.1 mM TEAC), lipid peroxidation inhibition, hydrogen peroxide, and free radical scavenging activities. The hepatoprotective activity of ET was studied using CCl4-induced liver toxicity in rats. Oral administration of ET (500 mg/kg) significantly reduced CCl4-induced hepatotoxicity in rats, as observed from the serum level of the liver enzyme aspartate aminotransferase (AST), alanine aminotransferase (ALT), and also from the histopathologic study. The total phenolic content in the lyophilized ethanol extract is approximately 10%. The results of the current study indicated that the hepatoprotective effect of E. tomentosus might be ascribable to its antioxidant and free radical scavenging properties. Informa Healthcare 2008-03 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13185/1/Antioxidant%20and%20hepatoprotective%20activities%20of%20Elephantopus%20tomentosus%20ethanol%20extract.pdf Yam, Mun Fei and Basir, Rusliza and Asmawil, Mohd Zaini and Rosidah, and Ahmad, Mariam and Akowuah, Gabriel Akyirem (2008) Antioxidant and hepatoprotective activities of Elephantopus tomentosus ethanol extract. Pharmaceutical Biology, 46 (3). pp. 199-206. ISSN 1388-0209; ESSN: 1744-5116 10.1080/13880200701735569 |
| spellingShingle | Yam, Mun Fei Basir, Rusliza Asmawil, Mohd Zaini Rosidah, Ahmad, Mariam Akowuah, Gabriel Akyirem Antioxidant and hepatoprotective activities of Elephantopus tomentosus ethanol extract. |
| title | Antioxidant and hepatoprotective activities of Elephantopus tomentosus ethanol extract. |
| title_full | Antioxidant and hepatoprotective activities of Elephantopus tomentosus ethanol extract. |
| title_fullStr | Antioxidant and hepatoprotective activities of Elephantopus tomentosus ethanol extract. |
| title_full_unstemmed | Antioxidant and hepatoprotective activities of Elephantopus tomentosus ethanol extract. |
| title_short | Antioxidant and hepatoprotective activities of Elephantopus tomentosus ethanol extract. |
| title_sort | antioxidant and hepatoprotective activities of elephantopus tomentosus ethanol extract. |
| url | http://psasir.upm.edu.my/id/eprint/13185/ http://psasir.upm.edu.my/id/eprint/13185/ http://psasir.upm.edu.my/id/eprint/13185/1/Antioxidant%20and%20hepatoprotective%20activities%20of%20Elephantopus%20tomentosus%20ethanol%20extract.pdf |