Antinociceptive, antiinflammatory and antipyretic properties of Channa striatus fillet aqueous and lipid-based extracts in rats
The present study was carried out to elucidate the antinociceptive, antiinflammatory and antipyretic properties of the aqueous and lipid-based extracts of Channa striatus fillet in rats. The antinociceptive activity was assessed using the formalin test, and the antiinflammatory and antipyretic activ...
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| Format: | Article |
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Prous Science
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13175/ http://psasir.upm.edu.my/id/eprint/13175/1/Antinociceptive%2C%20antiinflammatory%20and%20antipyretic%20properties%20of%20Channa%20striatus%20fillet%20aqueous%20and%20lipid-based%20extracts%20in%20rats..pdf |
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| author | Zakaria, Zainul Amiruddin Kumar, Gunjan Hanan Mat Jais, Abdul Manan Sulaiman, Mohd Roslan Somchit, Muhammad Nazrul |
| author_facet | Zakaria, Zainul Amiruddin Kumar, Gunjan Hanan Mat Jais, Abdul Manan Sulaiman, Mohd Roslan Somchit, Muhammad Nazrul |
| author_sort | Zakaria, Zainul Amiruddin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The present study was carried out to elucidate the antinociceptive, antiinflammatory and antipyretic properties of the aqueous and lipid-based extracts of Channa striatus fillet in rats. The antinociceptive activity was assessed using the formalin test, and the antiinflammatory and antipyretic activities were assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. Both types of extracts were prepared in concentrations of 10%, 50% and 100% by serial dilution in distilled water or dimethyl sulfoxide, respectively, and were administered subcutaneously 30 min prior to each test. Except for the 10% aqueous extract which exhibits activity only in the early phase, the extracts were found to exhibit significant (P < 0. 05) activity in the early and late phases of the formalin test. Furthermore, the aqueous and lipid-based extracts were also found to show significant (P < 0. 05) antiinflammatory activity, with the former showing a greater effect at the lowest concentration used. The lipid-based, but not the aqueous, extract was found to have significant (P < 0.05) activity in the pyrexia test. In conclusion, the present study demonstrated that C. striatus extracts possess antinociceptive, antiinflammatory and antipyretic activities. |
| first_indexed | 2025-11-15T07:52:48Z |
| format | Article |
| id | upm-13175 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:52:48Z |
| publishDate | 2008 |
| publisher | Prous Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-131752016-06-06T05:35:21Z http://psasir.upm.edu.my/id/eprint/13175/ Antinociceptive, antiinflammatory and antipyretic properties of Channa striatus fillet aqueous and lipid-based extracts in rats Zakaria, Zainul Amiruddin Kumar, Gunjan Hanan Mat Jais, Abdul Manan Sulaiman, Mohd Roslan Somchit, Muhammad Nazrul The present study was carried out to elucidate the antinociceptive, antiinflammatory and antipyretic properties of the aqueous and lipid-based extracts of Channa striatus fillet in rats. The antinociceptive activity was assessed using the formalin test, and the antiinflammatory and antipyretic activities were assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. Both types of extracts were prepared in concentrations of 10%, 50% and 100% by serial dilution in distilled water or dimethyl sulfoxide, respectively, and were administered subcutaneously 30 min prior to each test. Except for the 10% aqueous extract which exhibits activity only in the early phase, the extracts were found to exhibit significant (P < 0. 05) activity in the early and late phases of the formalin test. Furthermore, the aqueous and lipid-based extracts were also found to show significant (P < 0. 05) antiinflammatory activity, with the former showing a greater effect at the lowest concentration used. The lipid-based, but not the aqueous, extract was found to have significant (P < 0.05) activity in the pyrexia test. In conclusion, the present study demonstrated that C. striatus extracts possess antinociceptive, antiinflammatory and antipyretic activities. Prous Science 2008-06 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13175/1/Antinociceptive%2C%20antiinflammatory%20and%20antipyretic%20properties%20of%20Channa%20striatus%20fillet%20aqueous%20and%20lipid-based%20extracts%20in%20rats..pdf Zakaria, Zainul Amiruddin and Kumar, Gunjan Hanan and Mat Jais, Abdul Manan and Sulaiman, Mohd Roslan and Somchit, Muhammad Nazrul (2008) Antinociceptive, antiinflammatory and antipyretic properties of Channa striatus fillet aqueous and lipid-based extracts in rats. Methods and Findings in Experimental and Clinical Pharmacology, 30 (5). pp. 355-362. ISSN 0379-0355; ESSN: 2013-0155 |
| spellingShingle | Zakaria, Zainul Amiruddin Kumar, Gunjan Hanan Mat Jais, Abdul Manan Sulaiman, Mohd Roslan Somchit, Muhammad Nazrul Antinociceptive, antiinflammatory and antipyretic properties of Channa striatus fillet aqueous and lipid-based extracts in rats |
| title | Antinociceptive, antiinflammatory and antipyretic properties of Channa striatus fillet aqueous and lipid-based extracts in rats |
| title_full | Antinociceptive, antiinflammatory and antipyretic properties of Channa striatus fillet aqueous and lipid-based extracts in rats |
| title_fullStr | Antinociceptive, antiinflammatory and antipyretic properties of Channa striatus fillet aqueous and lipid-based extracts in rats |
| title_full_unstemmed | Antinociceptive, antiinflammatory and antipyretic properties of Channa striatus fillet aqueous and lipid-based extracts in rats |
| title_short | Antinociceptive, antiinflammatory and antipyretic properties of Channa striatus fillet aqueous and lipid-based extracts in rats |
| title_sort | antinociceptive, antiinflammatory and antipyretic properties of channa striatus fillet aqueous and lipid-based extracts in rats |
| url | http://psasir.upm.edu.my/id/eprint/13175/ http://psasir.upm.edu.my/id/eprint/13175/1/Antinociceptive%2C%20antiinflammatory%20and%20antipyretic%20properties%20of%20Channa%20striatus%20fillet%20aqueous%20and%20lipid-based%20extracts%20in%20rats..pdf |