Antinociceptive, antiinflammatory and antipyretic properties of Channa striatus fillet aqueous and lipid-based extracts in rats
The present study was carried out to elucidate the antinociceptive, antiinflammatory and antipyretic properties of the aqueous and lipid-based extracts of Channa striatus fillet in rats. The antinociceptive activity was assessed using the formalin test, and the antiinflammatory and antipyretic activ...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Prous Science
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13175/ http://psasir.upm.edu.my/id/eprint/13175/1/Antinociceptive%2C%20antiinflammatory%20and%20antipyretic%20properties%20of%20Channa%20striatus%20fillet%20aqueous%20and%20lipid-based%20extracts%20in%20rats..pdf |
| Summary: | The present study was carried out to elucidate the antinociceptive, antiinflammatory and antipyretic properties of the aqueous and lipid-based extracts of Channa striatus fillet in rats. The antinociceptive activity was assessed using the formalin test, and the antiinflammatory and antipyretic activities were assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. Both types of extracts were prepared in concentrations of 10%, 50% and 100% by serial dilution in distilled water or dimethyl sulfoxide, respectively, and were administered subcutaneously 30 min prior to each test. Except for the 10% aqueous extract which exhibits activity only in the early phase, the extracts were found to exhibit significant (P < 0. 05) activity in the early and late phases of the formalin test. Furthermore, the aqueous and lipid-based extracts were also found to show significant (P < 0. 05) antiinflammatory activity, with the former showing a greater effect at the lowest concentration used. The lipid-based, but not the aqueous, extract was found to have significant (P < 0.05) activity in the pyrexia test. In conclusion, the present study demonstrated that C. striatus extracts possess antinociceptive, antiinflammatory and antipyretic activities. |
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