Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models
This study was performed out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animals. The antinociceptive activity was measured using the abdominal constriction, hot plate, and formalin tests. The...
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| Format: | Article |
| Language: | English |
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Springer
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13174/ http://psasir.upm.edu.my/id/eprint/13174/1/Antinociceptive%2C%20antiinflammatory%20and%20antipyretic%20properties%20of%20Channa%20striatus%20fillet%20aqueous%20and%20lipid-based%20extracts%20in%20rats..pdf |
| _version_ | 1848842039954767872 |
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| author | Zakaria, Zainul Amiruddin Abdul Ghani, Zuleen Delina Fasya Raden Mohd Nor, Raden Nur Suraya Gopalan, Hanan Kumar Sulaiman, Mohd Roslan Mat Jais, Abdul Manan Somchit, Muhammad Nazrul Abdul Kadir, Arifah Ripin, Johari |
| author_facet | Zakaria, Zainul Amiruddin Abdul Ghani, Zuleen Delina Fasya Raden Mohd Nor, Raden Nur Suraya Gopalan, Hanan Kumar Sulaiman, Mohd Roslan Mat Jais, Abdul Manan Somchit, Muhammad Nazrul Abdul Kadir, Arifah Ripin, Johari |
| author_sort | Zakaria, Zainul Amiruddin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This study was performed out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animals. The antinociceptive activity was measured using the abdominal constriction, hot plate, and formalin tests. The anti-inflammatory and antipyretic activities were measured using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. The extract, obtained after 72 h soaking of the air-dried leaves in distilled water and then prepared in the doses of 13.2, 66.0, 132.0, and 660.0 mg/kg, was administered subcutaneously 30 min before subjecting the animals to the assays mentioned above. Generally, the extract, at all doses used, was found to have significant (P < 0.05) concentration-independent antinociceptive, anti-inflammatory, and anti-pyretic activity. In conclusion, the aqueous extract of D. linearis has antinociceptive, anti-inflammatory, and antipyretic activity, supporting previous claims of its traditional use by the Malays to treat various ailments, particularly fever. |
| first_indexed | 2025-11-15T07:52:48Z |
| format | Article |
| id | upm-13174 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:52:48Z |
| publishDate | 2008 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-131742016-09-01T03:03:43Z http://psasir.upm.edu.my/id/eprint/13174/ Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models Zakaria, Zainul Amiruddin Abdul Ghani, Zuleen Delina Fasya Raden Mohd Nor, Raden Nur Suraya Gopalan, Hanan Kumar Sulaiman, Mohd Roslan Mat Jais, Abdul Manan Somchit, Muhammad Nazrul Abdul Kadir, Arifah Ripin, Johari This study was performed out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animals. The antinociceptive activity was measured using the abdominal constriction, hot plate, and formalin tests. The anti-inflammatory and antipyretic activities were measured using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. The extract, obtained after 72 h soaking of the air-dried leaves in distilled water and then prepared in the doses of 13.2, 66.0, 132.0, and 660.0 mg/kg, was administered subcutaneously 30 min before subjecting the animals to the assays mentioned above. Generally, the extract, at all doses used, was found to have significant (P < 0.05) concentration-independent antinociceptive, anti-inflammatory, and anti-pyretic activity. In conclusion, the aqueous extract of D. linearis has antinociceptive, anti-inflammatory, and antipyretic activity, supporting previous claims of its traditional use by the Malays to treat various ailments, particularly fever. Springer 2008-04 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13174/1/Antinociceptive%2C%20antiinflammatory%20and%20antipyretic%20properties%20of%20Channa%20striatus%20fillet%20aqueous%20and%20lipid-based%20extracts%20in%20rats..pdf Zakaria, Zainul Amiruddin and Abdul Ghani, Zuleen Delina Fasya and Raden Mohd Nor, Raden Nur Suraya and Gopalan, Hanan Kumar and Sulaiman, Mohd Roslan and Mat Jais, Abdul Manan and Somchit, Muhammad Nazrul and Abdul Kadir, Arifah and Ripin, Johari (2008) Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models. Journal of Natural Medicines, 62 (2). pp. 179-187. ISSN 1340-3443; ESSN: 1861-0293 10.1007/s11418-007-0224-x |
| spellingShingle | Zakaria, Zainul Amiruddin Abdul Ghani, Zuleen Delina Fasya Raden Mohd Nor, Raden Nur Suraya Gopalan, Hanan Kumar Sulaiman, Mohd Roslan Mat Jais, Abdul Manan Somchit, Muhammad Nazrul Abdul Kadir, Arifah Ripin, Johari Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models |
| title | Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models |
| title_full | Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models |
| title_fullStr | Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models |
| title_full_unstemmed | Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models |
| title_short | Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models |
| title_sort | antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of dicranopteris linearis leaves in experimental animal models |
| url | http://psasir.upm.edu.my/id/eprint/13174/ http://psasir.upm.edu.my/id/eprint/13174/ http://psasir.upm.edu.my/id/eprint/13174/1/Antinociceptive%2C%20antiinflammatory%20and%20antipyretic%20properties%20of%20Channa%20striatus%20fillet%20aqueous%20and%20lipid-based%20extracts%20in%20rats..pdf |