Antinociceptive and anti-inflammatory effects of Sida rhombifolia L. in various animal models.
The present study was carried out to determine the antinociceptive and anti-inflammatory activities of the ethanolic extract of Sida rhombifolia L. leaves in various animal models. The antinociceptive activity was measured using the abdominal constriction test and hot plate test, while the anti-infl...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Published: |
Medwell Publishing
2008
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/13169/ |
| _version_ | 1848842038541287424 |
|---|---|
| author | Sulaiman, Mohd Roslan Moin, Saidi Alias, Ashraf S. Zakaria, Zainul Amiruddin |
| author_facet | Sulaiman, Mohd Roslan Moin, Saidi Alias, Ashraf S. Zakaria, Zainul Amiruddin |
| author_sort | Sulaiman, Mohd Roslan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The present study was carried out to determine the antinociceptive and anti-inflammatory activities of the ethanolic extract of Sida rhombifolia L. leaves in various animal models. The antinociceptive activity was measured using the abdominal constriction test and hot plate test, while the anti-inflammatory was assessed using the carrageenan-induced paw edema test. The dried leaves of S. rhombifolia was mixed with 95% ethanol (1: 10; w/v), incubated in water bath (55°C) for 72 h, filtered and evaporated to dryness (50°C) under reduced pressure. The sticky paste of extract was then emulsified using 0.1% Tween-80 in normal saline at concentrations required to produce doses of 30, 100 and 300 mg kg-1 body weight. Based on the data obtained, all doses of the extract, administered intraperitoneally, exhibited significant (p<0.05) antinociceptive and anti-inflammatory activities in a dose-dependent manner. In conclusion, the leaves of S.rhombifolia possessed antinociceptive and anti-inflammatory activities and confirms its traditional uses in the treatment of pain-and inflammatory-related ailments. |
| first_indexed | 2025-11-15T07:52:47Z |
| format | Article |
| id | upm-13169 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T07:52:47Z |
| publishDate | 2008 |
| publisher | Medwell Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-131692014-12-06T02:11:47Z http://psasir.upm.edu.my/id/eprint/13169/ Antinociceptive and anti-inflammatory effects of Sida rhombifolia L. in various animal models. Sulaiman, Mohd Roslan Moin, Saidi Alias, Ashraf S. Zakaria, Zainul Amiruddin The present study was carried out to determine the antinociceptive and anti-inflammatory activities of the ethanolic extract of Sida rhombifolia L. leaves in various animal models. The antinociceptive activity was measured using the abdominal constriction test and hot plate test, while the anti-inflammatory was assessed using the carrageenan-induced paw edema test. The dried leaves of S. rhombifolia was mixed with 95% ethanol (1: 10; w/v), incubated in water bath (55°C) for 72 h, filtered and evaporated to dryness (50°C) under reduced pressure. The sticky paste of extract was then emulsified using 0.1% Tween-80 in normal saline at concentrations required to produce doses of 30, 100 and 300 mg kg-1 body weight. Based on the data obtained, all doses of the extract, administered intraperitoneally, exhibited significant (p<0.05) antinociceptive and anti-inflammatory activities in a dose-dependent manner. In conclusion, the leaves of S.rhombifolia possessed antinociceptive and anti-inflammatory activities and confirms its traditional uses in the treatment of pain-and inflammatory-related ailments. Medwell Publishing 2008 Article PeerReviewed Sulaiman, Mohd Roslan and Moin, Saidi and Alias, Ashraf S. and Zakaria, Zainul Amiruddin (2008) Antinociceptive and anti-inflammatory effects of Sida rhombifolia L. in various animal models. Research Journal of Pharmacology, 2 (2). pp. 13-16. ISSN 1815-9362; ESSN: 1993-6019 http://www.medwelljournals.com/abstract/?doi=rjpharm.2008.13.16 |
| spellingShingle | Sulaiman, Mohd Roslan Moin, Saidi Alias, Ashraf S. Zakaria, Zainul Amiruddin Antinociceptive and anti-inflammatory effects of Sida rhombifolia L. in various animal models. |
| title | Antinociceptive and anti-inflammatory effects of Sida rhombifolia L. in various animal models. |
| title_full | Antinociceptive and anti-inflammatory effects of Sida rhombifolia L. in various animal models. |
| title_fullStr | Antinociceptive and anti-inflammatory effects of Sida rhombifolia L. in various animal models. |
| title_full_unstemmed | Antinociceptive and anti-inflammatory effects of Sida rhombifolia L. in various animal models. |
| title_short | Antinociceptive and anti-inflammatory effects of Sida rhombifolia L. in various animal models. |
| title_sort | antinociceptive and anti-inflammatory effects of sida rhombifolia l. in various animal models. |
| url | http://psasir.upm.edu.my/id/eprint/13169/ http://psasir.upm.edu.my/id/eprint/13169/ |