Antinociceptive and antiinflammatory activities of the aqueous extract of Trigonopleura malayana resin in experimental animal models.
Trigonopleura malayana L. (Euphorbiaceae) resin, locally known as Gambir Sarawak, has been used traditionally to alleviate pain associated with insect bites, muscle ache, toothache and minor injuries. The present study was carried out using various animal models to determine the antinociceptive and...
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| Format: | Article |
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Prous Science
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13166/ |
| _version_ | 1848842037762195456 |
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| author | Sulaiman, Mohd Roslan Zakaria, Zainul Amiruddin Kamaruddin, Anita Teoh, Fei Meng Israf Ali, Daud Ahmad Moin, Saidi |
| author_facet | Sulaiman, Mohd Roslan Zakaria, Zainul Amiruddin Kamaruddin, Anita Teoh, Fei Meng Israf Ali, Daud Ahmad Moin, Saidi |
| author_sort | Sulaiman, Mohd Roslan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Trigonopleura malayana L. (Euphorbiaceae) resin, locally known as Gambir Sarawak, has been used traditionally to alleviate pain associated with insect bites, muscle ache, toothache and minor injuries. The present study was carried out using various animal models to determine the antinociceptive and antiinflammatory activities of the T. malayana resin aqueous extract. Antinociceptive activity was measured using the abdominal constriction, hot plate and formalin tests, while antiinflammatory activity was measured using the carrageenan-induced paw edema test. The extract, obtained after 24 h of soaking the dried resin in distilled water, was prepared in doses of 0.3, 3 and 10 mg/kg and administered subcutaneously 30 min prior to the assays. The mechanism of action was also determined by prechallenging with naloxone (10 mg/kg), a nonselective opioid antagonist. The extract was found to exhibit significant (P < 0.05) and dose-dependent antinociceptive and antiinflammatory activities; naloxone failed to inhibit the former activity. In conclusion, the aqueous extract of T. malayana resin possesses nonopioid antinociceptive and antiinflammatory activities, thus supporting previous claims regarding its traditional use by the Malays to treat various ailments, particularly those related to pain. |
| first_indexed | 2025-11-15T07:52:46Z |
| format | Article |
| id | upm-13166 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T07:52:46Z |
| publishDate | 2008 |
| publisher | Prous Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-131662014-12-06T03:34:18Z http://psasir.upm.edu.my/id/eprint/13166/ Antinociceptive and antiinflammatory activities of the aqueous extract of Trigonopleura malayana resin in experimental animal models. Sulaiman, Mohd Roslan Zakaria, Zainul Amiruddin Kamaruddin, Anita Teoh, Fei Meng Israf Ali, Daud Ahmad Moin, Saidi Trigonopleura malayana L. (Euphorbiaceae) resin, locally known as Gambir Sarawak, has been used traditionally to alleviate pain associated with insect bites, muscle ache, toothache and minor injuries. The present study was carried out using various animal models to determine the antinociceptive and antiinflammatory activities of the T. malayana resin aqueous extract. Antinociceptive activity was measured using the abdominal constriction, hot plate and formalin tests, while antiinflammatory activity was measured using the carrageenan-induced paw edema test. The extract, obtained after 24 h of soaking the dried resin in distilled water, was prepared in doses of 0.3, 3 and 10 mg/kg and administered subcutaneously 30 min prior to the assays. The mechanism of action was also determined by prechallenging with naloxone (10 mg/kg), a nonselective opioid antagonist. The extract was found to exhibit significant (P < 0.05) and dose-dependent antinociceptive and antiinflammatory activities; naloxone failed to inhibit the former activity. In conclusion, the aqueous extract of T. malayana resin possesses nonopioid antinociceptive and antiinflammatory activities, thus supporting previous claims regarding its traditional use by the Malays to treat various ailments, particularly those related to pain. Prous Science 2008-11 Article PeerReviewed Sulaiman, Mohd Roslan and Zakaria, Zainul Amiruddin and Kamaruddin, Anita and Teoh, Fei Meng and Israf Ali, Daud Ahmad and Moin, Saidi (2008) Antinociceptive and antiinflammatory activities of the aqueous extract of Trigonopleura malayana resin in experimental animal models. Methods and Findings in Experimental and Clinical Pharmacology, 30 (9). pp. 691-696. ISSN 0379-0355; ESSN: 2013-0155 10.1358/mf.2008.30.9.1323494 |
| spellingShingle | Sulaiman, Mohd Roslan Zakaria, Zainul Amiruddin Kamaruddin, Anita Teoh, Fei Meng Israf Ali, Daud Ahmad Moin, Saidi Antinociceptive and antiinflammatory activities of the aqueous extract of Trigonopleura malayana resin in experimental animal models. |
| title | Antinociceptive and antiinflammatory activities of the aqueous extract of Trigonopleura malayana resin in experimental animal models. |
| title_full | Antinociceptive and antiinflammatory activities of the aqueous extract of Trigonopleura malayana resin in experimental animal models. |
| title_fullStr | Antinociceptive and antiinflammatory activities of the aqueous extract of Trigonopleura malayana resin in experimental animal models. |
| title_full_unstemmed | Antinociceptive and antiinflammatory activities of the aqueous extract of Trigonopleura malayana resin in experimental animal models. |
| title_short | Antinociceptive and antiinflammatory activities of the aqueous extract of Trigonopleura malayana resin in experimental animal models. |
| title_sort | antinociceptive and antiinflammatory activities of the aqueous extract of trigonopleura malayana resin in experimental animal models. |
| url | http://psasir.upm.edu.my/id/eprint/13166/ http://psasir.upm.edu.my/id/eprint/13166/ |