Antileukemic activity and chemical constituents of some Zingiberaceae species
Crude extracts of various solvents from six species (genus Alpinia, Zingiber, Kaempferia) of Zingiberaceae family have been chosen for the in vitro cytotoxic activity screening against the inhibition of HL-60 cell line (Human promyelocytic leukemia). Eight extracts (44 %) were found to have cytotoxi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Chemic Publishing Company
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13155/ http://psasir.upm.edu.my/id/eprint/13155/1/Antileukemic%20activity%20and%20chemical%20constituents%20of%20some%20Zingiberaceae%20species.pdf |
| _version_ | 1848842034576621568 |
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| author | Md.Sukari, Mohd. Aspollah Tang, Sook Wah Neoh, Bee Keat Ee, Gwendoline Cheng Lian Rahmani, Mawardi |
| author_facet | Md.Sukari, Mohd. Aspollah Tang, Sook Wah Neoh, Bee Keat Ee, Gwendoline Cheng Lian Rahmani, Mawardi |
| author_sort | Md.Sukari, Mohd. Aspollah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Crude extracts of various solvents from six species (genus Alpinia, Zingiber, Kaempferia) of Zingiberaceae family have been chosen for the in vitro cytotoxic activity screening against the inhibition of HL-60 cell line (Human promyelocytic leukemia). Eight extracts (44 %) were found to have cytotoxic activity with IC50 values less than 30 μg/mL, with Alpinia galanga showing the most prominent antileukemic activity. Further isolation work on Kaempferia galanga has yielded ethyl p-methoxy-trans-cinnamate (1), p-methoxy-trans-cinnamic acid (2) besides b-sitosterol. |
| first_indexed | 2025-11-15T07:52:43Z |
| format | Article |
| id | upm-13155 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:52:43Z |
| publishDate | 2010 |
| publisher | Chemic Publishing Company |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-131552015-10-20T23:47:26Z http://psasir.upm.edu.my/id/eprint/13155/ Antileukemic activity and chemical constituents of some Zingiberaceae species Md.Sukari, Mohd. Aspollah Tang, Sook Wah Neoh, Bee Keat Ee, Gwendoline Cheng Lian Rahmani, Mawardi Crude extracts of various solvents from six species (genus Alpinia, Zingiber, Kaempferia) of Zingiberaceae family have been chosen for the in vitro cytotoxic activity screening against the inhibition of HL-60 cell line (Human promyelocytic leukemia). Eight extracts (44 %) were found to have cytotoxic activity with IC50 values less than 30 μg/mL, with Alpinia galanga showing the most prominent antileukemic activity. Further isolation work on Kaempferia galanga has yielded ethyl p-methoxy-trans-cinnamate (1), p-methoxy-trans-cinnamic acid (2) besides b-sitosterol. Chemic Publishing Company 2010 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13155/1/Antileukemic%20activity%20and%20chemical%20constituents%20of%20some%20Zingiberaceae%20species.pdf Md.Sukari, Mohd. Aspollah and Tang, Sook Wah and Neoh, Bee Keat and Ee, Gwendoline Cheng Lian and Rahmani, Mawardi (2010) Antileukemic activity and chemical constituents of some Zingiberaceae species. Asian Journal of Chemistry, 22 (10). pp. 7891-7896. ISSN 0970-7077; ESSN: 0975-427X |
| spellingShingle | Md.Sukari, Mohd. Aspollah Tang, Sook Wah Neoh, Bee Keat Ee, Gwendoline Cheng Lian Rahmani, Mawardi Antileukemic activity and chemical constituents of some Zingiberaceae species |
| title | Antileukemic activity and chemical constituents of some Zingiberaceae species |
| title_full | Antileukemic activity and chemical constituents of some Zingiberaceae species |
| title_fullStr | Antileukemic activity and chemical constituents of some Zingiberaceae species |
| title_full_unstemmed | Antileukemic activity and chemical constituents of some Zingiberaceae species |
| title_short | Antileukemic activity and chemical constituents of some Zingiberaceae species |
| title_sort | antileukemic activity and chemical constituents of some zingiberaceae species |
| url | http://psasir.upm.edu.my/id/eprint/13155/ http://psasir.upm.edu.my/id/eprint/13155/1/Antileukemic%20activity%20and%20chemical%20constituents%20of%20some%20Zingiberaceae%20species.pdf |