Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice.
The anti-inflammatory activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated that intraperitoneal administration of 1 a...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
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Elsevier
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13154/ |
| _version_ | 1848842034292457472 |
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| author | Sulaiman, Mohd Roslan Perimal, Enoch Kumar Akhtar, Muhammad Nadeem Tengku Mohamad, Tengku Azam Shah Khalid, Mohamed Hanief Tasrip, Nor Asmara Mokhtar, Fuzi Zakaria, Zainul Amiruddin Lajis, Nordin Israf Ali, Daud Ahmad |
| author_facet | Sulaiman, Mohd Roslan Perimal, Enoch Kumar Akhtar, Muhammad Nadeem Tengku Mohamad, Tengku Azam Shah Khalid, Mohamed Hanief Tasrip, Nor Asmara Mokhtar, Fuzi Zakaria, Zainul Amiruddin Lajis, Nordin Israf Ali, Daud Ahmad |
| author_sort | Sulaiman, Mohd Roslan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The anti-inflammatory activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated that intraperitoneal administration of 1 at a dose of 5, 10, 50 and 100 mg/kg produced significant dose-dependent inhibition of paw edema induced by carrageenan. It was also demonstrated that 1 at similar doses significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test. |
| first_indexed | 2025-11-15T07:52:43Z |
| format | Article |
| id | upm-13154 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T07:52:43Z |
| publishDate | 2010 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-131542014-12-06T04:12:35Z http://psasir.upm.edu.my/id/eprint/13154/ Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. Sulaiman, Mohd Roslan Perimal, Enoch Kumar Akhtar, Muhammad Nadeem Tengku Mohamad, Tengku Azam Shah Khalid, Mohamed Hanief Tasrip, Nor Asmara Mokhtar, Fuzi Zakaria, Zainul Amiruddin Lajis, Nordin Israf Ali, Daud Ahmad The anti-inflammatory activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated that intraperitoneal administration of 1 at a dose of 5, 10, 50 and 100 mg/kg produced significant dose-dependent inhibition of paw edema induced by carrageenan. It was also demonstrated that 1 at similar doses significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test. Elsevier 2010-10 Article PeerReviewed Sulaiman, Mohd Roslan and Perimal, Enoch Kumar and Akhtar, Muhammad Nadeem and Tengku Mohamad, Tengku Azam Shah and Khalid, Mohamed Hanief and Tasrip, Nor Asmara and Mokhtar, Fuzi and Zakaria, Zainul Amiruddin and Lajis, Nordin and Israf Ali, Daud Ahmad (2010) Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. Fitoterapia, 81 (7). pp. 855-858. ISSN 0367-326X; ESSN: 1873-6971 10.1016/j.fitote.2010.05.009 |
| spellingShingle | Sulaiman, Mohd Roslan Perimal, Enoch Kumar Akhtar, Muhammad Nadeem Tengku Mohamad, Tengku Azam Shah Khalid, Mohamed Hanief Tasrip, Nor Asmara Mokhtar, Fuzi Zakaria, Zainul Amiruddin Lajis, Nordin Israf Ali, Daud Ahmad Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. |
| title | Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. |
| title_full | Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. |
| title_fullStr | Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. |
| title_full_unstemmed | Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. |
| title_short | Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. |
| title_sort | anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. |
| url | http://psasir.upm.edu.my/id/eprint/13154/ http://psasir.upm.edu.my/id/eprint/13154/ |