Anti-inflammatory and antinociceptive effects of Mitragyna speciosa Korth methanolic extract.
OBJECTIVES: To determine the anti-inflammatory and antinociceptive activities of Mitragyna speciosa Korth methanol extract in rodents. Materials and METHODS: Anti-inflammatory activity was evaluated using carrageenan-induced paw edema and cotton pellet-induced granuloma tests in rats. Antinocicep...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Karger
2009
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13151/ |
| _version_ | 1848842033399070720 |
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| author | Shaik Mossadeq, Wan Mastura Sulaiman, Mohd Roslan Tengku Mohamad, Tengku Azam Shah Chiong, Hoe Siong Zakaria, Zainul Amiruddin Jabit, Md Lip Baharuldin, Mohamad Taufik Hidayat Israf Ali, Daud Ahmad |
| author_facet | Shaik Mossadeq, Wan Mastura Sulaiman, Mohd Roslan Tengku Mohamad, Tengku Azam Shah Chiong, Hoe Siong Zakaria, Zainul Amiruddin Jabit, Md Lip Baharuldin, Mohamad Taufik Hidayat Israf Ali, Daud Ahmad |
| author_sort | Shaik Mossadeq, Wan Mastura |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | OBJECTIVES: To determine the anti-inflammatory and antinociceptive activities of Mitragyna speciosa Korth methanol extract in rodents. Materials and
METHODS: Anti-inflammatory activity was evaluated using carrageenan-induced paw edema and cotton pellet-induced granuloma tests in rats. Antinociceptive activity was measured using the writhing test and the hot plate test in mice, and the formalin test in rats. All drugs and extracts were diluted in dH(2)O and administered through the intraperitoneal route. Results were analyzed using one-way ANOVA followed by Dunnett's test for multiple comparisons among groups.
RESULTS: Results showed that intraperitoneal administration of the extract at doses of 100 and 200 mg/kg produced significant dose-dependent activity in all of the nociceptive models evaluated (p < 0.05). With the formalin test, the antinociceptive activity in mice was inhibited only at the highest dose of the extract (200 mg/kg). The study also showed that intraperitoneal administration of the methanol extract of M. speciosa (100 and 200 mg/kg) significantly and dose-dependently suppressed the development of carrageenan-induced rat paw edema (p < 0.05). In the chronic test, however, significant reduction in granulomatous tissue formation in rats was observed only at the highest dose of the methanol extract of M. speciosa (200 mg/kg, p < 0.05).
CONCLUSION: The present study suggests the presence of potent antinociceptive and anti-inflammatory principles in the extract, supporting its folkloric use for the treatment of these conditions.
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| first_indexed | 2025-11-15T07:52:42Z |
| format | Article |
| id | upm-13151 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:52:42Z |
| publishDate | 2009 |
| publisher | Karger |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-131512013-12-09T07:54:24Z http://psasir.upm.edu.my/id/eprint/13151/ Anti-inflammatory and antinociceptive effects of Mitragyna speciosa Korth methanolic extract. Shaik Mossadeq, Wan Mastura Sulaiman, Mohd Roslan Tengku Mohamad, Tengku Azam Shah Chiong, Hoe Siong Zakaria, Zainul Amiruddin Jabit, Md Lip Baharuldin, Mohamad Taufik Hidayat Israf Ali, Daud Ahmad OBJECTIVES: To determine the anti-inflammatory and antinociceptive activities of Mitragyna speciosa Korth methanol extract in rodents. Materials and METHODS: Anti-inflammatory activity was evaluated using carrageenan-induced paw edema and cotton pellet-induced granuloma tests in rats. Antinociceptive activity was measured using the writhing test and the hot plate test in mice, and the formalin test in rats. All drugs and extracts were diluted in dH(2)O and administered through the intraperitoneal route. Results were analyzed using one-way ANOVA followed by Dunnett's test for multiple comparisons among groups. RESULTS: Results showed that intraperitoneal administration of the extract at doses of 100 and 200 mg/kg produced significant dose-dependent activity in all of the nociceptive models evaluated (p < 0.05). With the formalin test, the antinociceptive activity in mice was inhibited only at the highest dose of the extract (200 mg/kg). The study also showed that intraperitoneal administration of the methanol extract of M. speciosa (100 and 200 mg/kg) significantly and dose-dependently suppressed the development of carrageenan-induced rat paw edema (p < 0.05). In the chronic test, however, significant reduction in granulomatous tissue formation in rats was observed only at the highest dose of the methanol extract of M. speciosa (200 mg/kg, p < 0.05). CONCLUSION: The present study suggests the presence of potent antinociceptive and anti-inflammatory principles in the extract, supporting its folkloric use for the treatment of these conditions. Karger 2009-08 Article PeerReviewed Shaik Mossadeq, Wan Mastura and Sulaiman, Mohd Roslan and Tengku Mohamad, Tengku Azam Shah and Chiong, Hoe Siong and Zakaria, Zainul Amiruddin and Jabit, Md Lip and Baharuldin, Mohamad Taufik Hidayat and Israf Ali, Daud Ahmad (2009) Anti-inflammatory and antinociceptive effects of Mitragyna speciosa Korth methanolic extract. Medical Principles and Practice, 18 (5). pp. 378-384. ISSN 1011-7571; ESSN:1423-0151 10.1159/000226292 English |
| spellingShingle | Shaik Mossadeq, Wan Mastura Sulaiman, Mohd Roslan Tengku Mohamad, Tengku Azam Shah Chiong, Hoe Siong Zakaria, Zainul Amiruddin Jabit, Md Lip Baharuldin, Mohamad Taufik Hidayat Israf Ali, Daud Ahmad Anti-inflammatory and antinociceptive effects of Mitragyna speciosa Korth methanolic extract. |
| title | Anti-inflammatory and antinociceptive effects of Mitragyna speciosa Korth methanolic extract. |
| title_full | Anti-inflammatory and antinociceptive effects of Mitragyna speciosa Korth methanolic extract. |
| title_fullStr | Anti-inflammatory and antinociceptive effects of Mitragyna speciosa Korth methanolic extract. |
| title_full_unstemmed | Anti-inflammatory and antinociceptive effects of Mitragyna speciosa Korth methanolic extract. |
| title_short | Anti-inflammatory and antinociceptive effects of Mitragyna speciosa Korth methanolic extract. |
| title_sort | anti-inflammatory and antinociceptive effects of mitragyna speciosa korth methanolic extract. |
| url | http://psasir.upm.edu.my/id/eprint/13151/ http://psasir.upm.edu.my/id/eprint/13151/ |