Anti-inflammatory and anti-nociceptive activities of the ethanolic extract of Annona muricata leaf
Ethanolic extract of Annona muricata leaf (AML) was used to investigate its anti-inflammatory and antinociceptive activities by using carrageenan - induced oedema model and acetic acid induced writhing test. AML exhibited significant and dose-dependent anti-inflammatory activity at a dose of 10, 30,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Informatics Publishing Limited and Natural Remedies
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13148/ http://psasir.upm.edu.my/id/eprint/13148/1/Anti-inflammatory.pdf |
| _version_ | 1848842032576987136 |
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| author | Abd Hamid @ Abdul Razak, Roslida Tay, C. E. Ahmad, Zuraini Chan, Pit Foong |
| author_facet | Abd Hamid @ Abdul Razak, Roslida Tay, C. E. Ahmad, Zuraini Chan, Pit Foong |
| author_sort | Abd Hamid @ Abdul Razak, Roslida |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Ethanolic extract of Annona muricata leaf (AML) was used to investigate its anti-inflammatory and antinociceptive activities by using carrageenan - induced oedema model and acetic acid induced writhing test. AML exhibited significant and dose-dependent anti-inflammatory activity at a dose of 10, 30, 100 and 300 mg/kg when administered orally. It is also demonstrated that the intraperitoneal administration of AML at a dose of 30, 100 and 300 mg/kg produced significant inhibition of abdominal constriction induced with 0.6% (v/v) acetic acid in dose dependent manner. These results indicate that AML exhibits significant anti-inflammatory and antinociceptive effects. |
| first_indexed | 2025-11-15T07:52:41Z |
| format | Article |
| id | upm-13148 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:52:41Z |
| publishDate | 2010 |
| publisher | Informatics Publishing Limited and Natural Remedies |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-131482017-08-14T09:13:35Z http://psasir.upm.edu.my/id/eprint/13148/ Anti-inflammatory and anti-nociceptive activities of the ethanolic extract of Annona muricata leaf Abd Hamid @ Abdul Razak, Roslida Tay, C. E. Ahmad, Zuraini Chan, Pit Foong Ethanolic extract of Annona muricata leaf (AML) was used to investigate its anti-inflammatory and antinociceptive activities by using carrageenan - induced oedema model and acetic acid induced writhing test. AML exhibited significant and dose-dependent anti-inflammatory activity at a dose of 10, 30, 100 and 300 mg/kg when administered orally. It is also demonstrated that the intraperitoneal administration of AML at a dose of 30, 100 and 300 mg/kg produced significant inhibition of abdominal constriction induced with 0.6% (v/v) acetic acid in dose dependent manner. These results indicate that AML exhibits significant anti-inflammatory and antinociceptive effects. Informatics Publishing Limited and Natural Remedies 2010-07 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13148/1/Anti-inflammatory.pdf Abd Hamid @ Abdul Razak, Roslida and Tay, C. E. and Ahmad, Zuraini and Chan, Pit Foong (2010) Anti-inflammatory and anti-nociceptive activities of the ethanolic extract of Annona muricata leaf. Journal of Natural Remedies, 10 (2). pp. 97-104. ISSN 0972-5547; ESSN: 2320-3358 http://www.informaticsjournals.com/index.php/jnr/article/view/249 |
| spellingShingle | Abd Hamid @ Abdul Razak, Roslida Tay, C. E. Ahmad, Zuraini Chan, Pit Foong Anti-inflammatory and anti-nociceptive activities of the ethanolic extract of Annona muricata leaf |
| title | Anti-inflammatory and anti-nociceptive activities of the ethanolic extract of Annona muricata leaf |
| title_full | Anti-inflammatory and anti-nociceptive activities of the ethanolic extract of Annona muricata leaf |
| title_fullStr | Anti-inflammatory and anti-nociceptive activities of the ethanolic extract of Annona muricata leaf |
| title_full_unstemmed | Anti-inflammatory and anti-nociceptive activities of the ethanolic extract of Annona muricata leaf |
| title_short | Anti-inflammatory and anti-nociceptive activities of the ethanolic extract of Annona muricata leaf |
| title_sort | anti-inflammatory and anti-nociceptive activities of the ethanolic extract of annona muricata leaf |
| url | http://psasir.upm.edu.my/id/eprint/13148/ http://psasir.upm.edu.my/id/eprint/13148/ http://psasir.upm.edu.my/id/eprint/13148/1/Anti-inflammatory.pdf |