Antihyperglycemic, hypolipidemic and antioxidant enzymes effect of Strobilanthes crispus juice in normal and streptozotocin-induced diabetic male and female rats
The aim of the present study was to investigate the effect of Strobilanthes crispus juice on glucose, lipid profile, glutathione peroxidase and superoxide dismutase in normal and streptozotocin-induced diabetic male and female albino Sprague-Dawley rats. This study was conducted on normal and strept...
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| Format: | Article |
| Language: | English |
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Asian Network for Scientific Information
2009
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13145/ http://psasir.upm.edu.my/id/eprint/13145/1/Antihyperglycemic.pdf |
| _version_ | 1848842031709814784 |
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| author | Noor Azmi, Norfarizan Hanoon Rahmat, Asmah Mohd Yusof, Rokiah Othman, Fauziah Hussin, Faridah |
| author_facet | Noor Azmi, Norfarizan Hanoon Rahmat, Asmah Mohd Yusof, Rokiah Othman, Fauziah Hussin, Faridah |
| author_sort | Noor Azmi, Norfarizan Hanoon |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The aim of the present study was to investigate the effect of Strobilanthes crispus juice on glucose, lipid profile, glutathione peroxidase and superoxide dismutase in normal and streptozotocin-induced diabetic male and female albino Sprague-Dawley rats. This study was conducted on normal and streptozotocin-induced diabetic male and female Sprague-Dawley rats fed with basal diet and S. crispus juice with different doses 1.0, 1.5 and 2.0 mL k-1 b.wt. for 30 days. The results showed that significant (p<0.05) decrease in serum glucose levels in male and female diabetic and normal rats with treated S. crispus juice (1.0, 1.5 and 2.0 mL k-1 b.wt.). Cholesterol and triglyceride level significantly (p<0.05) decreased in diabetic rats treated with 1.0, 1.5 and 2.0 mL k-1 b.wt. of S. crispus juice. Cholesterol, triglyceride and LDL-cholesterol level showed reduction in treated male and female normal rats. HDL-cholesterol showed the increasing but not significant (p<0.05) difference in treated diabetic and normal male and female rats. Glutathione peroxidase and superoxide dismutase activities significantly (p<0.05) increased in treated diabetic and normal male and female rats. In conclusion, S. crispus juice possesses antihyperglycemic, hypolipidemic and antioxidant effect in streptozotocin-induced diabetic rats. Thus, S. crispus juice could be the alternative treatment for lowering glucose, cholesterol and triglyceride for diabetic patients in the future. |
| first_indexed | 2025-11-15T07:52:40Z |
| format | Article |
| id | upm-13145 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:52:40Z |
| publishDate | 2009 |
| publisher | Asian Network for Scientific Information |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-131452015-12-18T03:17:17Z http://psasir.upm.edu.my/id/eprint/13145/ Antihyperglycemic, hypolipidemic and antioxidant enzymes effect of Strobilanthes crispus juice in normal and streptozotocin-induced diabetic male and female rats Noor Azmi, Norfarizan Hanoon Rahmat, Asmah Mohd Yusof, Rokiah Othman, Fauziah Hussin, Faridah The aim of the present study was to investigate the effect of Strobilanthes crispus juice on glucose, lipid profile, glutathione peroxidase and superoxide dismutase in normal and streptozotocin-induced diabetic male and female albino Sprague-Dawley rats. This study was conducted on normal and streptozotocin-induced diabetic male and female Sprague-Dawley rats fed with basal diet and S. crispus juice with different doses 1.0, 1.5 and 2.0 mL k-1 b.wt. for 30 days. The results showed that significant (p<0.05) decrease in serum glucose levels in male and female diabetic and normal rats with treated S. crispus juice (1.0, 1.5 and 2.0 mL k-1 b.wt.). Cholesterol and triglyceride level significantly (p<0.05) decreased in diabetic rats treated with 1.0, 1.5 and 2.0 mL k-1 b.wt. of S. crispus juice. Cholesterol, triglyceride and LDL-cholesterol level showed reduction in treated male and female normal rats. HDL-cholesterol showed the increasing but not significant (p<0.05) difference in treated diabetic and normal male and female rats. Glutathione peroxidase and superoxide dismutase activities significantly (p<0.05) increased in treated diabetic and normal male and female rats. In conclusion, S. crispus juice possesses antihyperglycemic, hypolipidemic and antioxidant effect in streptozotocin-induced diabetic rats. Thus, S. crispus juice could be the alternative treatment for lowering glucose, cholesterol and triglyceride for diabetic patients in the future. Asian Network for Scientific Information 2009 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13145/1/Antihyperglycemic.pdf Noor Azmi, Norfarizan Hanoon and Rahmat, Asmah and Mohd Yusof, Rokiah and Othman, Fauziah and Hussin, Faridah (2009) Antihyperglycemic, hypolipidemic and antioxidant enzymes effect of Strobilanthes crispus juice in normal and streptozotocin-induced diabetic male and female rats. International Journal of Pharmacology, 5 (3). pp. 200-2007. ISSN 1811-7775; ESSN: 1812-5700 http://scialert.net/abstract/?doi=ijp.2009.200.207 10.3923/ijp.2009.200.207 |
| spellingShingle | Noor Azmi, Norfarizan Hanoon Rahmat, Asmah Mohd Yusof, Rokiah Othman, Fauziah Hussin, Faridah Antihyperglycemic, hypolipidemic and antioxidant enzymes effect of Strobilanthes crispus juice in normal and streptozotocin-induced diabetic male and female rats |
| title | Antihyperglycemic, hypolipidemic and antioxidant enzymes effect of Strobilanthes crispus juice in normal and streptozotocin-induced diabetic male and female rats |
| title_full | Antihyperglycemic, hypolipidemic and antioxidant enzymes effect of Strobilanthes crispus juice in normal and streptozotocin-induced diabetic male and female rats |
| title_fullStr | Antihyperglycemic, hypolipidemic and antioxidant enzymes effect of Strobilanthes crispus juice in normal and streptozotocin-induced diabetic male and female rats |
| title_full_unstemmed | Antihyperglycemic, hypolipidemic and antioxidant enzymes effect of Strobilanthes crispus juice in normal and streptozotocin-induced diabetic male and female rats |
| title_short | Antihyperglycemic, hypolipidemic and antioxidant enzymes effect of Strobilanthes crispus juice in normal and streptozotocin-induced diabetic male and female rats |
| title_sort | antihyperglycemic, hypolipidemic and antioxidant enzymes effect of strobilanthes crispus juice in normal and streptozotocin-induced diabetic male and female rats |
| url | http://psasir.upm.edu.my/id/eprint/13145/ http://psasir.upm.edu.my/id/eprint/13145/ http://psasir.upm.edu.my/id/eprint/13145/ http://psasir.upm.edu.my/id/eprint/13145/1/Antihyperglycemic.pdf |