Anticancerous efect of Typhonium flagelliforme on human T4-lymphoblastoid cell line CEM-ss
Typhonium flagelliforme (Lodd.) Blume, commonly known as rodent tuber in Malaysia, is one of the widely used alternative medicines in cancer therapy by South East Asian population. Intake of this plant is common among patients with malignancies especially Leukaemia, breast and cervical cancer; howev...
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| Format: | Article |
| Language: | English |
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Academic Journals
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13140/ http://psasir.upm.edu.my/id/eprint/13140/1/Anticancerous%20efect%20of%20Typhonium%20flagelliforme%20on%20human%20T4.pdf |
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| author | Mohan, Syam Abdul, Ahmad Bustamam Abdelwahab, Siddiq Ibrahim Al-Zubairi, Adel Sharaf Sukari, Mohd Aspollah |
| author_facet | Mohan, Syam Abdul, Ahmad Bustamam Abdelwahab, Siddiq Ibrahim Al-Zubairi, Adel Sharaf Sukari, Mohd Aspollah |
| author_sort | Mohan, Syam |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Typhonium flagelliforme (Lodd.) Blume, commonly known as rodent tuber in Malaysia, is one of the widely used alternative medicines in cancer therapy by South East Asian population. Intake of this plant is common among patients with malignancies especially Leukaemia, breast and cervical cancer; however no data available regarding the possible direct effect of T flagelliforme in these cancers. The purpose of the present study was to investigate the potential m vitro cytotoxic effect of leaves and tubers of T. flagelliforme extracts against human T4-lymphoblastoid cell line CEM-ss. Among the 8 extracts Dichloromethane and Ethyl acetate extracts of T. flagelliforme demonstrated significant anti proliferative effect with a marked level for both leaves (10.8 and 5.8 μg mL-1) and tuber (6.5 and 8.2 μg mL-1), against CEM-ss cells. Considering all the results collectively T. flagelliforme appears to be a promising plant demonstrating anti cancer activity, that requires further investigation.
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| first_indexed | 2025-11-15T07:52:39Z |
| format | Article |
| id | upm-13140 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:52:39Z |
| publishDate | 2008 |
| publisher | Academic Journals |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-131402015-10-23T06:37:32Z http://psasir.upm.edu.my/id/eprint/13140/ Anticancerous efect of Typhonium flagelliforme on human T4-lymphoblastoid cell line CEM-ss Mohan, Syam Abdul, Ahmad Bustamam Abdelwahab, Siddiq Ibrahim Al-Zubairi, Adel Sharaf Sukari, Mohd Aspollah Typhonium flagelliforme (Lodd.) Blume, commonly known as rodent tuber in Malaysia, is one of the widely used alternative medicines in cancer therapy by South East Asian population. Intake of this plant is common among patients with malignancies especially Leukaemia, breast and cervical cancer; however no data available regarding the possible direct effect of T flagelliforme in these cancers. The purpose of the present study was to investigate the potential m vitro cytotoxic effect of leaves and tubers of T. flagelliforme extracts against human T4-lymphoblastoid cell line CEM-ss. Among the 8 extracts Dichloromethane and Ethyl acetate extracts of T. flagelliforme demonstrated significant anti proliferative effect with a marked level for both leaves (10.8 and 5.8 μg mL-1) and tuber (6.5 and 8.2 μg mL-1), against CEM-ss cells. Considering all the results collectively T. flagelliforme appears to be a promising plant demonstrating anti cancer activity, that requires further investigation. Academic Journals 2008-11 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13140/1/Anticancerous%20efect%20of%20Typhonium%20flagelliforme%20on%20human%20T4.pdf Mohan, Syam and Abdul, Ahmad Bustamam and Abdelwahab, Siddiq Ibrahim and Al-Zubairi, Adel Sharaf and Sukari, Mohd Aspollah (2008) Anticancerous efect of Typhonium flagelliforme on human T4-lymphoblastoid cell line CEM-ss. Journal of Pharmacology and Toxicology, 3 (6). pp. 449-456. ISSN 1816-496X; ESSN: 2152-100X http://scialert.net/abstract/?doi=jpt.2008.449.456 10.3923/jpt.2008.449.456 |
| spellingShingle | Mohan, Syam Abdul, Ahmad Bustamam Abdelwahab, Siddiq Ibrahim Al-Zubairi, Adel Sharaf Sukari, Mohd Aspollah Anticancerous efect of Typhonium flagelliforme on human T4-lymphoblastoid cell line CEM-ss |
| title | Anticancerous efect of Typhonium flagelliforme on human T4-lymphoblastoid cell line CEM-ss |
| title_full | Anticancerous efect of Typhonium flagelliforme on human T4-lymphoblastoid cell line CEM-ss |
| title_fullStr | Anticancerous efect of Typhonium flagelliforme on human T4-lymphoblastoid cell line CEM-ss |
| title_full_unstemmed | Anticancerous efect of Typhonium flagelliforme on human T4-lymphoblastoid cell line CEM-ss |
| title_short | Anticancerous efect of Typhonium flagelliforme on human T4-lymphoblastoid cell line CEM-ss |
| title_sort | anticancerous efect of typhonium flagelliforme on human t4-lymphoblastoid cell line cem-ss |
| url | http://psasir.upm.edu.my/id/eprint/13140/ http://psasir.upm.edu.my/id/eprint/13140/ http://psasir.upm.edu.my/id/eprint/13140/ http://psasir.upm.edu.my/id/eprint/13140/1/Anticancerous%20efect%20of%20Typhonium%20flagelliforme%20on%20human%20T4.pdf |