Anti-adhesive and anti-invasive activities of an oil based di-herbal extract against methicillin resistant Staphylococcus aureus
Staphylococcus aureus is a major human pathogen capable of causing a wide range of infections. Treatment of S. aureus infections is becoming more challenging with the continuous emergence of new strains of methicillin resistantS. aureus (MRSA) from hospital and community. The aim of the present stud...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Academic Journals
2009
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13127/ http://psasir.upm.edu.my/id/eprint/13127/1/13127.pdf |
| _version_ | 1848842026714398720 |
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| author | Rad, Ehsanollah Ghaznavi Neela, Vasantha Kumari Chong, Pei Pei Sekawi, Zamberi Shamsudin, Mariana Nor |
| author_facet | Rad, Ehsanollah Ghaznavi Neela, Vasantha Kumari Chong, Pei Pei Sekawi, Zamberi Shamsudin, Mariana Nor |
| author_sort | Rad, Ehsanollah Ghaznavi |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Staphylococcus aureus is a major human pathogen capable of causing a wide range of infections. Treatment of S. aureus infections is becoming more challenging with the continuous emergence of new strains of methicillin resistantS. aureus (MRSA) from hospital and community. The aim of the present study is to formulate an oil based combinatorial herbal extract which will not only have antibacterial effect for treatment, but also anti-adhesive and anti-invasive activities against MRSA for to be used as a prophylactic agent. Based on the Indian and Iranian traditional medicine, herbs such as barberry and turmeric which has medicinal properties are tested against MRSA. MRSA and S. aureus strains exposed to oil based di-herbal extract prepared from coconut oil, barberry and turmeric suppressed the partial expression of fibronectin binding protein (FNBP) encoded by fibronectin binding gene (fnbA), that establishes the attachment to and invasion of host cells. Results from the current study showed that the formulated extract has good anti-bacterial, anti-adhesive and anti-invasive activity against S. aureus and MRSA as it showed good zone of inhibition (15 mm) and inhibited the FNB protein synthesis. The formulated combinatorial herbal extract thus could be used for the treatment of S. aureus and MRSA infections as well as for prophylaxis; thus controls the spread of MDR S. aureus strains in hospital and community. |
| first_indexed | 2025-11-15T07:52:35Z |
| format | Article |
| id | upm-13127 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:52:35Z |
| publishDate | 2009 |
| publisher | Academic Journals |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-131272017-11-17T08:20:52Z http://psasir.upm.edu.my/id/eprint/13127/ Anti-adhesive and anti-invasive activities of an oil based di-herbal extract against methicillin resistant Staphylococcus aureus Rad, Ehsanollah Ghaznavi Neela, Vasantha Kumari Chong, Pei Pei Sekawi, Zamberi Shamsudin, Mariana Nor Staphylococcus aureus is a major human pathogen capable of causing a wide range of infections. Treatment of S. aureus infections is becoming more challenging with the continuous emergence of new strains of methicillin resistantS. aureus (MRSA) from hospital and community. The aim of the present study is to formulate an oil based combinatorial herbal extract which will not only have antibacterial effect for treatment, but also anti-adhesive and anti-invasive activities against MRSA for to be used as a prophylactic agent. Based on the Indian and Iranian traditional medicine, herbs such as barberry and turmeric which has medicinal properties are tested against MRSA. MRSA and S. aureus strains exposed to oil based di-herbal extract prepared from coconut oil, barberry and turmeric suppressed the partial expression of fibronectin binding protein (FNBP) encoded by fibronectin binding gene (fnbA), that establishes the attachment to and invasion of host cells. Results from the current study showed that the formulated extract has good anti-bacterial, anti-adhesive and anti-invasive activity against S. aureus and MRSA as it showed good zone of inhibition (15 mm) and inhibited the FNB protein synthesis. The formulated combinatorial herbal extract thus could be used for the treatment of S. aureus and MRSA infections as well as for prophylaxis; thus controls the spread of MDR S. aureus strains in hospital and community. Academic Journals 2009-05 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13127/1/13127.pdf Rad, Ehsanollah Ghaznavi and Neela, Vasantha Kumari and Chong, Pei Pei and Sekawi, Zamberi and Shamsudin, Mariana Nor (2009) Anti-adhesive and anti-invasive activities of an oil based di-herbal extract against methicillin resistant Staphylococcus aureus. African Journal of Microbiology Research, 3 (5). art. no. CB1758312472. pp. 272-275. ISSN 1996-0808 http://www.academicjournals.org/journal/AJMR/article-abstract/CB1758312472 |
| spellingShingle | Rad, Ehsanollah Ghaznavi Neela, Vasantha Kumari Chong, Pei Pei Sekawi, Zamberi Shamsudin, Mariana Nor Anti-adhesive and anti-invasive activities of an oil based di-herbal extract against methicillin resistant Staphylococcus aureus |
| title | Anti-adhesive and anti-invasive activities of an oil based di-herbal extract against methicillin resistant Staphylococcus aureus |
| title_full | Anti-adhesive and anti-invasive activities of an oil based di-herbal extract against methicillin resistant Staphylococcus aureus |
| title_fullStr | Anti-adhesive and anti-invasive activities of an oil based di-herbal extract against methicillin resistant Staphylococcus aureus |
| title_full_unstemmed | Anti-adhesive and anti-invasive activities of an oil based di-herbal extract against methicillin resistant Staphylococcus aureus |
| title_short | Anti-adhesive and anti-invasive activities of an oil based di-herbal extract against methicillin resistant Staphylococcus aureus |
| title_sort | anti-adhesive and anti-invasive activities of an oil based di-herbal extract against methicillin resistant staphylococcus aureus |
| url | http://psasir.upm.edu.my/id/eprint/13127/ http://psasir.upm.edu.my/id/eprint/13127/ http://psasir.upm.edu.my/id/eprint/13127/1/13127.pdf |