An investigation of the anti-inflammatory and analgesic effects of Orthosiphon stamineus leaf extracts
Anti-inflammatory and analgesic activities of a standardized Orthosiphon stamineus methanol:water (50:50 vol/vol) leaf extract (SEOS) were evaluated in animal models. Oral administration of SEOS at doses of 500 and 1,000 mg/kg significantly reduced the hind paw edema in rats at 3 and 5 hours after c...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Mary Ann Liebert
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13049/ http://psasir.upm.edu.my/id/eprint/13049/1/An%20investigation%20of%20the%20anti-inflammatory%20and%20analgesic%20effects%20of%20Orthosiphon%20stamineus%20leaf%20extracts.pdf |
| _version_ | 1848842005324496896 |
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| author | Yam, Mun Fei Asmawi, Mohd Zaini Basir, Rusliza |
| author_facet | Yam, Mun Fei Asmawi, Mohd Zaini Basir, Rusliza |
| author_sort | Yam, Mun Fei |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Anti-inflammatory and analgesic activities of a standardized Orthosiphon stamineus methanol:water (50:50 vol/vol) leaf extract (SEOS) were evaluated in animal models. Oral administration of SEOS at doses of 500 and 1,000 mg/kg significantly reduced the hind paw edema in rats at 3 and 5 hours after carrageenan administration (P < .01 and P < .01; P < .01 and P < .05, respectively). SEOS (1,000 mg/kg, p.o.) also produced significant (P < .05) analgesic activity in both the acetic acid-induced writhing test and the formalin-induced licking test (late phase) in mice and rats, respectively. However, SEOS showed no effect on the tail flick and hot plate tests in mice. The results of the present study support the proposal that O. stamineus has anti-inflammatory and non-narcotic analgesic activities. These findings justify the traditional use of the plant for treating pain and inflammation. |
| first_indexed | 2025-11-15T07:52:15Z |
| format | Article |
| id | upm-13049 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:52:15Z |
| publishDate | 2008 |
| publisher | Mary Ann Liebert |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-130492019-11-01T03:27:56Z http://psasir.upm.edu.my/id/eprint/13049/ An investigation of the anti-inflammatory and analgesic effects of Orthosiphon stamineus leaf extracts Yam, Mun Fei Asmawi, Mohd Zaini Basir, Rusliza Anti-inflammatory and analgesic activities of a standardized Orthosiphon stamineus methanol:water (50:50 vol/vol) leaf extract (SEOS) were evaluated in animal models. Oral administration of SEOS at doses of 500 and 1,000 mg/kg significantly reduced the hind paw edema in rats at 3 and 5 hours after carrageenan administration (P < .01 and P < .01; P < .01 and P < .05, respectively). SEOS (1,000 mg/kg, p.o.) also produced significant (P < .05) analgesic activity in both the acetic acid-induced writhing test and the formalin-induced licking test (late phase) in mice and rats, respectively. However, SEOS showed no effect on the tail flick and hot plate tests in mice. The results of the present study support the proposal that O. stamineus has anti-inflammatory and non-narcotic analgesic activities. These findings justify the traditional use of the plant for treating pain and inflammation. Mary Ann Liebert 2008-06 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13049/1/An%20investigation%20of%20the%20anti-inflammatory%20and%20analgesic%20effects%20of%20Orthosiphon%20stamineus%20leaf%20extracts.pdf Yam, Mun Fei and Asmawi, Mohd Zaini and Basir, Rusliza (2008) An investigation of the anti-inflammatory and analgesic effects of Orthosiphon stamineus leaf extracts. Journal of Medicinal Food, 11 (2). pp. 362-368. ISSN 1096-620X; ESSN: 1557-7600 |
| spellingShingle | Yam, Mun Fei Asmawi, Mohd Zaini Basir, Rusliza An investigation of the anti-inflammatory and analgesic effects of Orthosiphon stamineus leaf extracts |
| title | An investigation of the anti-inflammatory and analgesic effects of Orthosiphon stamineus leaf extracts |
| title_full | An investigation of the anti-inflammatory and analgesic effects of Orthosiphon stamineus leaf extracts |
| title_fullStr | An investigation of the anti-inflammatory and analgesic effects of Orthosiphon stamineus leaf extracts |
| title_full_unstemmed | An investigation of the anti-inflammatory and analgesic effects of Orthosiphon stamineus leaf extracts |
| title_short | An investigation of the anti-inflammatory and analgesic effects of Orthosiphon stamineus leaf extracts |
| title_sort | investigation of the anti-inflammatory and analgesic effects of orthosiphon stamineus leaf extracts |
| url | http://psasir.upm.edu.my/id/eprint/13049/ http://psasir.upm.edu.my/id/eprint/13049/1/An%20investigation%20of%20the%20anti-inflammatory%20and%20analgesic%20effects%20of%20Orthosiphon%20stamineus%20leaf%20extracts.pdf |