Alkaloids and carboxylic acids from Piper nigrum
Detailed chemical studies were carried out on the roots of Piper nigrum. Six alkaloids and four carboxylic acids were isolated and identified from this study. The alkaloids were piperolactam A (1), piperolactam D (2), cepharadione A (3), piperine (4), sylvamide (5) and 2,4-tetradecadienoic acid isob...
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| Format: | Article |
| Language: | English |
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Asian Publication Corporation
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/12983/ http://psasir.upm.edu.my/id/eprint/12983/1/Alkaloids%20and%20carboxylic%20acids%20from%20Piper%20nigrum.pdf |
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| author | Ee, Gwendoline Cheng Lian Lim, S. K. Lim, Chyi Meei Abdullah, Dzulkefly Kuang |
| author_facet | Ee, Gwendoline Cheng Lian Lim, S. K. Lim, Chyi Meei Abdullah, Dzulkefly Kuang |
| author_sort | Ee, Gwendoline Cheng Lian |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Detailed chemical studies were carried out on the roots of Piper nigrum. Six alkaloids and four carboxylic acids were isolated and identified from this study. The alkaloids were piperolactam A (1), piperolactam D (2), cepharadione A (3), piperine (4), sylvamide (5) and 2,4-tetradecadienoic acid isobutyl amide (6). The carboxylic acids were tetracosanoic acid, p-hydroxy-m-methoxycinnamate ester (7), 3,4-methylenedioxycinnamic acid (8), 2-butenedioic acid, mono-(2-methylpropyl) ester (9) and 3,4-methylenedioxy benzoic acid (10). Larvicidal assays on Aedes aegypti were carried out on the crude extracts of these plants as well as the pure compounds. The larvae were found to be susceptible to some of these extracts and compounds. This paper reports the isolation and characterization of these compounds as well as bioassay data. This is the first report on the presence of piperolactam A (1), piperolactam D (2) cepharadione A (3) and sylvamide (5) in Piper nigrum. |
| first_indexed | 2025-11-15T07:51:57Z |
| format | Article |
| id | upm-12983 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:51:57Z |
| publishDate | 2008 |
| publisher | Asian Publication Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-129832018-06-11T08:41:33Z http://psasir.upm.edu.my/id/eprint/12983/ Alkaloids and carboxylic acids from Piper nigrum Ee, Gwendoline Cheng Lian Lim, S. K. Lim, Chyi Meei Abdullah, Dzulkefly Kuang Detailed chemical studies were carried out on the roots of Piper nigrum. Six alkaloids and four carboxylic acids were isolated and identified from this study. The alkaloids were piperolactam A (1), piperolactam D (2), cepharadione A (3), piperine (4), sylvamide (5) and 2,4-tetradecadienoic acid isobutyl amide (6). The carboxylic acids were tetracosanoic acid, p-hydroxy-m-methoxycinnamate ester (7), 3,4-methylenedioxycinnamic acid (8), 2-butenedioic acid, mono-(2-methylpropyl) ester (9) and 3,4-methylenedioxy benzoic acid (10). Larvicidal assays on Aedes aegypti were carried out on the crude extracts of these plants as well as the pure compounds. The larvae were found to be susceptible to some of these extracts and compounds. This paper reports the isolation and characterization of these compounds as well as bioassay data. This is the first report on the presence of piperolactam A (1), piperolactam D (2) cepharadione A (3) and sylvamide (5) in Piper nigrum. Asian Publication Corporation 2008 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/12983/1/Alkaloids%20and%20carboxylic%20acids%20from%20Piper%20nigrum.pdf Ee, Gwendoline Cheng Lian and Lim, S. K. and Lim, Chyi Meei and Abdullah, Dzulkefly Kuang (2008) Alkaloids and carboxylic acids from Piper nigrum. Asian Journal of Chemistry, 20 (8). pp. 5931-5940. ISSN 0970-7077; ESSN: 0975-427X http://www.asianjournalofchemistry.co.in/user/journal/viewarticle.aspx?ArticleID=20_8_19 |
| spellingShingle | Ee, Gwendoline Cheng Lian Lim, S. K. Lim, Chyi Meei Abdullah, Dzulkefly Kuang Alkaloids and carboxylic acids from Piper nigrum |
| title | Alkaloids and carboxylic acids from Piper nigrum |
| title_full | Alkaloids and carboxylic acids from Piper nigrum |
| title_fullStr | Alkaloids and carboxylic acids from Piper nigrum |
| title_full_unstemmed | Alkaloids and carboxylic acids from Piper nigrum |
| title_short | Alkaloids and carboxylic acids from Piper nigrum |
| title_sort | alkaloids and carboxylic acids from piper nigrum |
| url | http://psasir.upm.edu.my/id/eprint/12983/ http://psasir.upm.edu.my/id/eprint/12983/ http://psasir.upm.edu.my/id/eprint/12983/1/Alkaloids%20and%20carboxylic%20acids%20from%20Piper%20nigrum.pdf |