A synthetic hydroxypropenone inhibits nitric oxide, prostaglandin E2, and proinflammatory cytokine synthesis

HMP [3-(2-hydroxyphenyl)-1-(5-methyl-furan-2-y-l) propenone] was evaluated for its ability to inhibit the synthesis of major proinflammatory mediators and cytokines in interferon-gamma (IFN-gamma)- and lipopolysaccharide (LPS)-induced RAW 264.7 cells and phorbol myristate acetate (PMA)-differentiate...

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Main Authors: Liew, Choi Yi, Tham, Chau Ling, Lam, Kok Wai, Tengku Mohamad, Tengku Azam Shah, Kim, Min Kyu, Cheah, Yoke Kqueen, Zakaria, Zainul Amiruddin, Sulaiman, Mohd Roslan, Lajis, Md Nordin, Israf Ali, Daud Ahmad
Format: Article
Language:English
Published: Informa Healthcare 2010
Online Access:http://psasir.upm.edu.my/id/eprint/12887/
http://psasir.upm.edu.my/id/eprint/12887/1/A%20synthetic%20hydroxypropenone%20inhibits%20nitric%20oxide.pdf
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author Liew, Choi Yi
Tham, Chau Ling
Lam, Kok Wai
Tengku Mohamad, Tengku Azam Shah
Kim, Min Kyu
Cheah, Yoke Kqueen
Zakaria, Zainul Amiruddin
Sulaiman, Mohd Roslan
Lajis, Md Nordin
Israf Ali, Daud Ahmad
author_facet Liew, Choi Yi
Tham, Chau Ling
Lam, Kok Wai
Tengku Mohamad, Tengku Azam Shah
Kim, Min Kyu
Cheah, Yoke Kqueen
Zakaria, Zainul Amiruddin
Sulaiman, Mohd Roslan
Lajis, Md Nordin
Israf Ali, Daud Ahmad
author_sort Liew, Choi Yi
building UPM Institutional Repository
collection Online Access
description HMP [3-(2-hydroxyphenyl)-1-(5-methyl-furan-2-y-l) propenone] was evaluated for its ability to inhibit the synthesis of major proinflammatory mediators and cytokines in interferon-gamma (IFN-gamma)- and lipopolysaccharide (LPS)-induced RAW 264.7 cells and phorbol myristate acetate (PMA)-differentiated/LPS-induced U937 cells. HMP suppressed the production of nitric oxide (NO) with significant inhibitory effects at doses as low as 0.78 microM (P < 0.05). Prostaglandin E2 (PGE2) secretion was also inhibited at doses of 12.5 microM and above (P < 0.01). The secretion of both TNF-alpha and IL-6 were only inhibited at the highest dose used (25 microM; P < 0.001). IL-1beta secretion was also inhibited from 12.5 microM onwards (P < 0.01). This inhibition was demonstrated to be caused by down-regulation of inducible enzymes, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2), without direct effect upon iNOS or COX-2 enzyme activity. HMP only inhibited iNOS (P < 0.001) and IL-1beta (P < 0.05) gene expression at the highest tested concentration. HMP did not affect the secretion of chemokines IL-8 and monocyte chemotactic protein-1 (MCP-1) and the anti-inflammatory cytokine IL-10. The most striking effect of HMP was its NO inhibitory activity and therefore we conclude that HMP is a selective inhibitor of iNOS.
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spelling upm-128872015-10-05T03:10:01Z http://psasir.upm.edu.my/id/eprint/12887/ A synthetic hydroxypropenone inhibits nitric oxide, prostaglandin E2, and proinflammatory cytokine synthesis Liew, Choi Yi Tham, Chau Ling Lam, Kok Wai Tengku Mohamad, Tengku Azam Shah Kim, Min Kyu Cheah, Yoke Kqueen Zakaria, Zainul Amiruddin Sulaiman, Mohd Roslan Lajis, Md Nordin Israf Ali, Daud Ahmad HMP [3-(2-hydroxyphenyl)-1-(5-methyl-furan-2-y-l) propenone] was evaluated for its ability to inhibit the synthesis of major proinflammatory mediators and cytokines in interferon-gamma (IFN-gamma)- and lipopolysaccharide (LPS)-induced RAW 264.7 cells and phorbol myristate acetate (PMA)-differentiated/LPS-induced U937 cells. HMP suppressed the production of nitric oxide (NO) with significant inhibitory effects at doses as low as 0.78 microM (P < 0.05). Prostaglandin E2 (PGE2) secretion was also inhibited at doses of 12.5 microM and above (P < 0.01). The secretion of both TNF-alpha and IL-6 were only inhibited at the highest dose used (25 microM; P < 0.001). IL-1beta secretion was also inhibited from 12.5 microM onwards (P < 0.01). This inhibition was demonstrated to be caused by down-regulation of inducible enzymes, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2), without direct effect upon iNOS or COX-2 enzyme activity. HMP only inhibited iNOS (P < 0.001) and IL-1beta (P < 0.05) gene expression at the highest tested concentration. HMP did not affect the secretion of chemokines IL-8 and monocyte chemotactic protein-1 (MCP-1) and the anti-inflammatory cytokine IL-10. The most striking effect of HMP was its NO inhibitory activity and therefore we conclude that HMP is a selective inhibitor of iNOS. Informa Healthcare 2010-09 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/12887/1/A%20synthetic%20hydroxypropenone%20inhibits%20nitric%20oxide.pdf Liew, Choi Yi and Tham, Chau Ling and Lam, Kok Wai and Tengku Mohamad, Tengku Azam Shah and Kim, Min Kyu and Cheah, Yoke Kqueen and Zakaria, Zainul Amiruddin and Sulaiman, Mohd Roslan and Lajis, Md Nordin and Israf Ali, Daud Ahmad (2010) A synthetic hydroxypropenone inhibits nitric oxide, prostaglandin E2, and proinflammatory cytokine synthesis. Immunopharmacology and Immunotoxicology, 32 (3). pp. 495-509. ISSN 0892-3973; ESSN: 1532-2513 http://informahealthcare.com/doi/abs/10.3109/08923970903575708 10.3109/08923970903575708
spellingShingle Liew, Choi Yi
Tham, Chau Ling
Lam, Kok Wai
Tengku Mohamad, Tengku Azam Shah
Kim, Min Kyu
Cheah, Yoke Kqueen
Zakaria, Zainul Amiruddin
Sulaiman, Mohd Roslan
Lajis, Md Nordin
Israf Ali, Daud Ahmad
A synthetic hydroxypropenone inhibits nitric oxide, prostaglandin E2, and proinflammatory cytokine synthesis
title A synthetic hydroxypropenone inhibits nitric oxide, prostaglandin E2, and proinflammatory cytokine synthesis
title_full A synthetic hydroxypropenone inhibits nitric oxide, prostaglandin E2, and proinflammatory cytokine synthesis
title_fullStr A synthetic hydroxypropenone inhibits nitric oxide, prostaglandin E2, and proinflammatory cytokine synthesis
title_full_unstemmed A synthetic hydroxypropenone inhibits nitric oxide, prostaglandin E2, and proinflammatory cytokine synthesis
title_short A synthetic hydroxypropenone inhibits nitric oxide, prostaglandin E2, and proinflammatory cytokine synthesis
title_sort synthetic hydroxypropenone inhibits nitric oxide, prostaglandin e2, and proinflammatory cytokine synthesis
url http://psasir.upm.edu.my/id/eprint/12887/
http://psasir.upm.edu.my/id/eprint/12887/
http://psasir.upm.edu.my/id/eprint/12887/
http://psasir.upm.edu.my/id/eprint/12887/1/A%20synthetic%20hydroxypropenone%20inhibits%20nitric%20oxide.pdf