A synthetic curcuminoid derivative inhibits nitric oxide and proinflammatory cytokine synthesis

QR Code

A synthetic curcuminoid derivative inhibits nitric oxide and proinflammatory cytokine synthesis

Curcumin is a highly pleiotropic molecule with significant regulatory effects upon inflammation and inflammatory related diseases. However curcumin has one major important limitation in which it has poor bioavailability. Design of synthetic structural derivatives of curcumin is but one approach that...

Full description

Bibliographic Details
Main Authors:	Tham, Chau Ling, Liew, Choi Yi, Lam, Kok Wai, Tengku Mohamad, Tengku Azam Shah, Kim, Min Kyu, Cheah, Yoke Kqueen, Zakaria, Zainul Amiruddin, Sulaiman, Mohd Roslan, Lajis, Nordin, Israf Ali, Daud Ahmad
Format:	Article
Language:	English
Published:	Elsevier 2010
Online Access:	http://psasir.upm.edu.my/id/eprint/12886/ http://psasir.upm.edu.my/id/eprint/12886/1/A%20synthetic%20curcuminoid%20derivative%20inhibits%20nitric%20oxide%20and%20proinflammatory%20cytokine%20synthesis.pdf

Similar Items

A synthetic hydroxypropenone inhibits nitric oxide, prostaglandin E2, and proinflammatory cytokine synthesis
by: Liew, Choi Yi, et al.
Published: (2010)

The effects of a synthetic curcuminoid analogue,2,6-bis-(4-hydroxyl-3-methoxybenzylidine)cyclohexanone on proinflammatorysignaling pathways and CLP-induced lethal sepsis in mice.
by: Chau, Ling Tham, et al.
Published: (2011)

Flavonoid combinations cause synergistic inhibition of proinflammatory mediator secretion from lipopolysaccharide-induced RAW 264.7 cells.
by: Harasstani, Omar A., et al.
Published: (2010)

Atrovirinone inhibits proinflammatory mediator synthesis through disruption of NF-kappaB nuclear translocation and MAPK phosphorylation in the murine monocytic macrophage RAW 264.7.
by: Israf Ali, Daud Ahmad, et al.
Published: (2010)

The synthetic curcuminoid BHMC restores endotoxin-stimulated HUVEC dysfunction: specific disruption on enzymatic activity of p38 MAPK
by: Chau, Ling Tham, et al.
Published: (2015)

Effect of proinflammatory cytokines on lung and intestinal mucosal permeability in vitro
by: Alshehri, Abdullah Ali
Published: (2013)

Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives
by: Leong, Sze Wei, et al.
Published: (2015)

A synthetic curcuminoid analogue, 2,6-Bis-4-(Hydroxyl-3-Methoxybenzylidine)-Cyclohexanone (BHMC) ameliorates acute airway inflammation of allergic asthma in ovalbumin-sensitized mice
by: Tham, Chau Ling, et al.
Published: (2021)

Antinociceptive activity of a synthetic curcuminoid analogue, 2,6-bis-(4-hydroxy-3-methoxybenzylidene)cyclohexanone, on nociception-induced models in mice.
by: Lee, Ming Tatt, et al.
Published: (2012)

Suppression of proinflammatory cytokines and mediators in LPS-induced RAW 264.7 macrophages by stem extract of Alternanthera sessilis via the inhibition of the NF-κB pathway
by: Muniandy, Katyakyini, et al.
Published: (2018)

Genetic polymorphisms of proinflammatory (IL-1β) cytokines in Malay male drug abusers with Hepatitis C infection
by: Lansayan, Jalviana
Published: (2022)

Neuroprotective effects of biochanin A against glutamate-induced cytotoxicity in PC12 cells via apoptosis inhibition
by: Tan, Ji Wei, et al.
Published: (2013)

Effects of 3-(2-Hydroxyphenyl)-1-(5-methyl-furan-2-y-l) propenone (HMP) upon signalling pathways of lipopolysaccharide-induced iNOS synthesis in RAW 264.7 cells.
by: Choi, Yi Liew, et al.
Published: (2011)

Inhibition of epithelial CC-family chemokine synthesis by the synthetic chalcone DMPF-1 via disruption of NF-κB nuclear translocation and suppression of experimental asthma in mice
by: Rajajendram, Revathee, et al.
Published: (2015)

Neuroprotective effects of biochanin A against glutamate-induced cytotoxicity in PC12 cells via apoptosis inhibition
by: Tan, Ji Wei, et al.
Published: (2013)

Antioxidant, antityrosinase, anticholinesterase, and nitric oxide inhibition activities of three Malaysian Macaranga species.
by: Mazlan, Nor Aishah, et al.
Published: (2013)

Innovative Microcapsules for Pancreatic ß-Cells Harvested from Mature Double-Transgenic Mice: Cell Imaging, Viability, Induced Glucose-Stimulated Insulin Measurements and Proinflammatory Cytokines Analysis
by: Mooranian, Armin, et al.
Published: (2017)

A synthetic curcumin-like diarylpentanoid analog inhibits rhinovirus infection in H1 hela cells via multiple antiviral mechanisms
by: Liew, Kong Yen, et al.
Published: (2024)

Inhibition of nitric oxide production in RAW 264.7 cells and cytokines IL-1β in osteoarthritis rat models of 70 % ethanol extract of Arcangelisia flava (L.) merr stems
by: Pratama, Rizki Rahmadi, et al.
Published: (2024)

The effects of curcuminoids on musculoskeletal pain: a systematic review.
by: Gaffey, A., et al.
Published: (2017)

Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxideinhibitors
by: Mohd Faudzi, Siti Munirah Mohd Faudzi, et al.
Published: (2015)

Role of exosomes as a proinflammatory mediator in the development of EBV-associated lymphoma
by: Higuchi, Hiroshi, et al.
Published: (2018)

Severe affective and behavioral Dysregulation in youths is associated with a proinflammatory state
by: Holtmann, M., et al.
Published: (2013)

The chronic cerebral hypoperfusion model induces proinflammatory cascades in Alzheimer's disease
by: Abedi, Zahra, et al.
Published: (2024)

Zerumbone-induced antinociception: involvement of the L-arginine-nitric oxide-cGMP -PKC-K+ ATP channel pathways.
by: Perimal, Enoch Kumar, et al.
Published: (2011)

Cardamonin inhibits nitric oxide production modulated through NMDA receptor in LPS-induced SH-SY5Y cell in vitro model
by: Kaswan, Nur Khalisah, et al.
Published: (2020)

Complex Coacervated Microcapsules In Cream For Topical Delivery Of The Curcuminoids And Quercetin
by: Ang , Lee Fung
Published: (2015)

Antinociceptive profile of a synthetic curcuminoid derivative, 2,6-bis-4-(hydroxy-3-methoxy-benzilidine)-cyclohexanone in murine model of induced-nociception
by: Lee, Ming Tatt
Published: (2013)

Antinociceptive activity of a synthetic chalcone, flavokawin B on chemical and thermal models of nociception in mice
by: Tengku Mohamad, Tengku Azam Shah, et al.
Published: (2010)

Bixa orellana leaves extract inhibits bradykinin-induced inflammation through suppression of nitric oxide production
by: Yong, Yoke Keong, et al.
Published: (2011)

In vitro and in vivo antioxidant studies of curcuminoids extract and fractions / Noorhaslina Hashim
by: Hashim, Noorhaslina
Published: (2011)

Chromaticity Investigation Of Curcuminoid Dye Composite For White Light Down-Conversion
by: Al Shafouri, Mahmood Shaikhan Ta’eeb
Published: (2020)

Rhinovirus-induced cytokine alterations with potential implications in asthma exacerbations: a systematic review and meta-analysis
by: Liew, Kong Yen, et al.
Published: (2022)

Biodiesel exhaust-induced cytotoxicity and proinflammatory mediator production in human airway epithelial cells
by: Mullins, Ben, et al.
Published: (2016)

Chromaticity Properties Of Curcuminoids Dye Nanofibers Prepared By Electrospinning For White Light Downconversion
by: Al Shafouri, Mahmood Shaikhan Taeeb Said, et al.
Published: (2019)

Evaluation of antioxidant and nitric oxide inhibitory activities of selected Malaysian medicinal plants
by: Saha, Koushik, et al.
Published: (2004)

Anti-inflammatory activity of 5-(3,4-dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl)penta-2,4-dien-1-one (synthetic curcuminoid analogue) in mice
by: Hisamuddin, Nadia
Published: (2019)

Antinociceptive activity of a synthetic curcuminoid analogue, 5-(3, 4-dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl) penta-2,4-dien-1-one in mice
by: Kamarudin, Nur Nadhirah
Published: (2019)

Peripheral antinociception of a chalcone, flavokawin B and possible involvement of the nitric oxide/cyclic guanosine monophosphate/potassium channels pathway
by: Kamaldin, Mohd Nasier, et al.
Published: (2013)

Cytotoxic and nitric oxide inhibitory activities of methanol extracts of Garcinia species.
by: Jabit, Md Lip, et al.
Published: (2009)