A synthetic curcuminoid derivative inhibits nitric oxide and proinflammatory cytokine synthesis
Curcumin is a highly pleiotropic molecule with significant regulatory effects upon inflammation and inflammatory related diseases. However curcumin has one major important limitation in which it has poor bioavailability. Design of synthetic structural derivatives of curcumin is but one approach that...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2010
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/12886/ http://psasir.upm.edu.my/id/eprint/12886/1/A%20synthetic%20curcuminoid%20derivative%20inhibits%20nitric%20oxide%20and%20proinflammatory%20cytokine%20synthesis.pdf |
| _version_ | 1848841958685933568 |
|---|---|
| author | Tham, Chau Ling Liew, Choi Yi Lam, Kok Wai Tengku Mohamad, Tengku Azam Shah Kim, Min Kyu Cheah, Yoke Kqueen Zakaria, Zainul Amiruddin Sulaiman, Mohd Roslan Lajis, Nordin Israf Ali, Daud Ahmad |
| author_facet | Tham, Chau Ling Liew, Choi Yi Lam, Kok Wai Tengku Mohamad, Tengku Azam Shah Kim, Min Kyu Cheah, Yoke Kqueen Zakaria, Zainul Amiruddin Sulaiman, Mohd Roslan Lajis, Nordin Israf Ali, Daud Ahmad |
| author_sort | Tham, Chau Ling |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Curcumin is a highly pleiotropic molecule with significant regulatory effects upon inflammation and inflammatory related diseases. However curcumin has one major important limitation in which it has poor bioavailability. Design of synthetic structural derivatives of curcumin is but one approach that has been used to overcome its poor bioavailability while retaining, or further enhancing, its drug-like effects. We have synthesized a series of curcumin analogues and describe the effects of 2,6-bis-4-(hydroxyl-3-methoxy-benzylidine)-cyclohexanone or BHMC upon nitric oxide and cytokine synthesis in cellular models of inflammation. BHMC showed a significant dose-response inhibitory action upon the synthesis of NO and we have shown that this effect was due to suppression of both iNOS gene and enzyme expression without any effects upon scavenging of nitrite. We also demonstrated that BHMC has a very minimal effect upon iNOS activity with no effect at all upon the secretion of PGE(2) but has a strong inhibitory effect upon MCP-1 and IL-10 secretion and gene expression. Secretion and gene expression of TNF-alpha and IL-6 were moderately inhibited whereas IL-8 and IL-1beta were not altered. We conclude that BHMC selectively inhibits the synthesis of several inflammatory mediators. BHMC should be considered a promising drug lead for preclinical and further pharmacological studies. |
| first_indexed | 2025-11-15T07:51:31Z |
| format | Article |
| id | upm-12886 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:51:31Z |
| publishDate | 2010 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-128862016-01-12T07:43:45Z http://psasir.upm.edu.my/id/eprint/12886/ A synthetic curcuminoid derivative inhibits nitric oxide and proinflammatory cytokine synthesis Tham, Chau Ling Liew, Choi Yi Lam, Kok Wai Tengku Mohamad, Tengku Azam Shah Kim, Min Kyu Cheah, Yoke Kqueen Zakaria, Zainul Amiruddin Sulaiman, Mohd Roslan Lajis, Nordin Israf Ali, Daud Ahmad Curcumin is a highly pleiotropic molecule with significant regulatory effects upon inflammation and inflammatory related diseases. However curcumin has one major important limitation in which it has poor bioavailability. Design of synthetic structural derivatives of curcumin is but one approach that has been used to overcome its poor bioavailability while retaining, or further enhancing, its drug-like effects. We have synthesized a series of curcumin analogues and describe the effects of 2,6-bis-4-(hydroxyl-3-methoxy-benzylidine)-cyclohexanone or BHMC upon nitric oxide and cytokine synthesis in cellular models of inflammation. BHMC showed a significant dose-response inhibitory action upon the synthesis of NO and we have shown that this effect was due to suppression of both iNOS gene and enzyme expression without any effects upon scavenging of nitrite. We also demonstrated that BHMC has a very minimal effect upon iNOS activity with no effect at all upon the secretion of PGE(2) but has a strong inhibitory effect upon MCP-1 and IL-10 secretion and gene expression. Secretion and gene expression of TNF-alpha and IL-6 were moderately inhibited whereas IL-8 and IL-1beta were not altered. We conclude that BHMC selectively inhibits the synthesis of several inflammatory mediators. BHMC should be considered a promising drug lead for preclinical and further pharmacological studies. Elsevier 2010-02 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/12886/1/A%20synthetic%20curcuminoid%20derivative%20inhibits%20nitric%20oxide%20and%20proinflammatory%20cytokine%20synthesis.pdf Tham, Chau Ling and Liew, Choi Yi and Lam, Kok Wai and Tengku Mohamad, Tengku Azam Shah and Kim, Min Kyu and Cheah, Yoke Kqueen and Zakaria, Zainul Amiruddin and Sulaiman, Mohd Roslan and Lajis, Nordin and Israf Ali, Daud Ahmad (2010) A synthetic curcuminoid derivative inhibits nitric oxide and proinflammatory cytokine synthesis. European Journal of Pharmacology, 628 (1-3). pp. 247-254. ISSN 0014-2999; ESSN: 1879-0712 10.1016/j.ejphar.2009.11.053 |
| spellingShingle | Tham, Chau Ling Liew, Choi Yi Lam, Kok Wai Tengku Mohamad, Tengku Azam Shah Kim, Min Kyu Cheah, Yoke Kqueen Zakaria, Zainul Amiruddin Sulaiman, Mohd Roslan Lajis, Nordin Israf Ali, Daud Ahmad A synthetic curcuminoid derivative inhibits nitric oxide and proinflammatory cytokine synthesis |
| title | A synthetic curcuminoid derivative inhibits nitric oxide and proinflammatory cytokine synthesis |
| title_full | A synthetic curcuminoid derivative inhibits nitric oxide and proinflammatory cytokine synthesis |
| title_fullStr | A synthetic curcuminoid derivative inhibits nitric oxide and proinflammatory cytokine synthesis |
| title_full_unstemmed | A synthetic curcuminoid derivative inhibits nitric oxide and proinflammatory cytokine synthesis |
| title_short | A synthetic curcuminoid derivative inhibits nitric oxide and proinflammatory cytokine synthesis |
| title_sort | synthetic curcuminoid derivative inhibits nitric oxide and proinflammatory cytokine synthesis |
| url | http://psasir.upm.edu.my/id/eprint/12886/ http://psasir.upm.edu.my/id/eprint/12886/ http://psasir.upm.edu.my/id/eprint/12886/1/A%20synthetic%20curcuminoid%20derivative%20inhibits%20nitric%20oxide%20and%20proinflammatory%20cytokine%20synthesis.pdf |