Interfacial elastic relaxation during the ejection of bi-layered tablets
The predilection of a bi-layered tablet to fail in the interface region after its initial formation in the compaction process reduces its practicality as a choice for controlled release solid drug delivery system. Hence, a fundamental appreciation of the governing mechanism that causes the weakening...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/12396/ http://psasir.upm.edu.my/id/eprint/12396/1/Interfacial%20elastic%20relaxation%20during%20the%20ejection%20of%20bi.pdf |
| _version_ | 1848841832926019584 |
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| author | Anuar, Mohd Shamsul Briscoe, B. J. |
| author_facet | Anuar, Mohd Shamsul Briscoe, B. J. |
| author_sort | Anuar, Mohd Shamsul |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The predilection of a bi-layered tablet to fail in the interface region after its initial formation in the compaction process reduces its practicality as a choice for controlled release solid drug delivery system. Hence, a fundamental appreciation of the governing mechanism that causes the weakening of the interfacial bonds within the bi-layered tablet is crucial in order to improve the overall bi-layered tablet mechanical integrity. This work has shown that the occurrence of the elastic relaxation in the interface region during the ejection stage of the compaction process decreases with the increase in the bi-layered tablet interface strength. This is believed to be due to the increase in the plastic bonding in the interface region. The tablet diametrical elastic relaxation affects the tablet height elastic relaxation, where the impediment of the tablet height expansion is observed when the interface region experiences a diametrical expansion.
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| first_indexed | 2025-11-15T07:49:31Z |
| format | Article |
| id | upm-12396 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:49:31Z |
| publishDate | 2010 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-123962016-02-03T02:58:39Z http://psasir.upm.edu.my/id/eprint/12396/ Interfacial elastic relaxation during the ejection of bi-layered tablets Anuar, Mohd Shamsul Briscoe, B. J. The predilection of a bi-layered tablet to fail in the interface region after its initial formation in the compaction process reduces its practicality as a choice for controlled release solid drug delivery system. Hence, a fundamental appreciation of the governing mechanism that causes the weakening of the interfacial bonds within the bi-layered tablet is crucial in order to improve the overall bi-layered tablet mechanical integrity. This work has shown that the occurrence of the elastic relaxation in the interface region during the ejection stage of the compaction process decreases with the increase in the bi-layered tablet interface strength. This is believed to be due to the increase in the plastic bonding in the interface region. The tablet diametrical elastic relaxation affects the tablet height elastic relaxation, where the impediment of the tablet height expansion is observed when the interface region experiences a diametrical expansion. 2010-03 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/12396/1/Interfacial%20elastic%20relaxation%20during%20the%20ejection%20of%20bi.pdf Anuar, Mohd Shamsul and Briscoe, B. J. (2010) Interfacial elastic relaxation during the ejection of bi-layered tablets. International Journal of Pharmaceutics, 387 (1-2). pp. 42-47. ISSN 0378-5173 http://dx.doi.org/10.1016/j.ijpharm.2009.11.031 10.1016/j.ijpharm.2009.11.031 |
| spellingShingle | Anuar, Mohd Shamsul Briscoe, B. J. Interfacial elastic relaxation during the ejection of bi-layered tablets |
| title | Interfacial elastic relaxation during the ejection of bi-layered tablets |
| title_full | Interfacial elastic relaxation during the ejection of bi-layered tablets |
| title_fullStr | Interfacial elastic relaxation during the ejection of bi-layered tablets |
| title_full_unstemmed | Interfacial elastic relaxation during the ejection of bi-layered tablets |
| title_short | Interfacial elastic relaxation during the ejection of bi-layered tablets |
| title_sort | interfacial elastic relaxation during the ejection of bi-layered tablets |
| url | http://psasir.upm.edu.my/id/eprint/12396/ http://psasir.upm.edu.my/id/eprint/12396/ http://psasir.upm.edu.my/id/eprint/12396/ http://psasir.upm.edu.my/id/eprint/12396/1/Interfacial%20elastic%20relaxation%20during%20the%20ejection%20of%20bi.pdf |