Supplementation with fish oil reduces αβ 42 burden and shifts αβ precursor protein processing toward non-amyloidogenic pathways in a rat model of hyperglycaemic Alzheimer’s disease.

QR Code

Supplementation with fish oil reduces αβ 42 burden and shifts αβ precursor protein processing toward non-amyloidogenic pathways in a rat model of hyperglycaemic Alzheimer’s disease.

This study examines the influence of fish oil on brain amyloidogenesis in hyperglycaemic Alzheimer’s disease animal models, emphasising the potential of omega-3 fatty acids in fish oil to prevent the development of Alzheimer’s disease. Thirty males of Wistar rats were divided into five groups: 1) co...

Full description

Bibliographic Details
Main Authors:	Titisari, Nurina, Fauzi, Ahmad, Abdul Razak, Intan Shameha, Samsulrizal, Nurdiana, Ahmad, Hafandi
Format:	Article
Language:	English
Published:	Cambridge University Press 2025
Online Access:	http://psasir.upm.edu.my/id/eprint/121062/ http://psasir.upm.edu.my/id/eprint/121062/1/121062.pdf

Similar Items

The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer’s disease animal model
by: Titisari, Nurina, et al.
Published: (2025)

Dietary menhaden fish oil supplementation suppresses lipopolysaccharide-induced neuroinflammation and cognitive impairment in diabetic rats
by: Titisari, Nurina, et al.
Published: (2024)

Brain cognitive performance and histopathological effects of diabetic rats induced by single and multiple dosages of streptozotocin
by: Titisari, Nurina, et al.
Published: (2024)

The Role of Amyloidogenic Peptides in Disruption of Insulin Secretion and Action
by: Rowles, Joanne Elizabeth
Published: (2023)

Modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (F70hab16) from Malaysian Endophyte Cytospora Rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James
by: James, Richard Muhammad Johari
Published: (2014)

Modulation of the amyloidogenic pathway by a Novel β-secretase inhibitor (F70HAB16) from Malaysian endophyte cytospora rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James
by: Muhammad Johari James, Richard
Published: (2014)

Charles Bonnet Syndrome: A Precursor To Alzheimer Disease
by: Janaki V.,, et al.
Published: (2015)

Computational Elucidation Of Binding Interactions For Thicapa And Poet On Amyloid Beta 42 And Presenilin 1 In Treating Alzheimer’s Disease
by: Mohd Suhaimi, Ahmad Marwazi
Published: (2024)

Reduced awareness of executive dysfunction in Alzheimer's disease is associated with increased carer burden
by: Booney, K., et al.
Published: (2007)

Unveiling amyloid-β1–42 interaction with zinc in water and mixed hexafluoroisopropanol solution in Alzheimer’s disease
by: Ghani, Nur Syafiqah Abdul, et al.
Published: (2017)

Antioxidant and anti hyperglycaemic activities of Aquilaria sinensis leaves (Gaharu) / Ranjitah V. Rajah
by: Ranjitah V. , Rajah
Published: (2018)

Identifying needs, burden, and distress of carers of people with Frontotemporal dementia compared to Alzheimer’s disease
by: Nicolaou, Paula, et al.
Published: (2010)

Molecular simulation between amyloid beta (1-42), a Peptide associated with alzheimer disease, and zinc(ii) ion
by: Abdul Ghani, Nur Syafiqah
Published: (2016)

42 syukur terima biasiswa
by: Harian metro, Nadzim Ahmad Jamaludin
Published: (2004)

Effect of Ficus deltoidea leaves on glucose and glycogen metabolism in liver of normal and streptozotocin-induced diabetic rats / Nurdiana Samsulrizal
by: Samsulrizal, Nurdiana
Published: (2008)

Effects of Ficus deltoidea Jack and vitexin on pancreas, brain, kidney and bone of streptozotocin-induced diabetic rats
by: Samsulrizal, Nurdiana
Published: (2017)

Pharmacokinetic and Drug Absorption Profiles of the Anti-Hyperglycaemic Agent Gliclazide in Oral Tissue-Targeted Microcapsules in Rats
by: Jovic, Jelena, et al.
Published: (2020)

Screening exons 16 and 17 of the amyloid precursor protein gene in sporadic early-onset Alzheimer’s disease
by: Barber, Imelda S., et al.
Published: (2016)

Screening exon 16 and 17 of the amyloid precursor protein gene in sporadic early-onset Alzheimer's disease
by: Barber, Imelda S., et al.
Published: (2016)

Shifting to Circular Manufacturing in the Global South: Challenges and Pathways
by: Hira, A., et al.
Published: (2022)

42 peratus tempatan
by: Basaruddin, Nabil
Published: (2017)

Glycogen synthase kinase-3? (GSK3?) inhibition by kaempferol mediates the anti-hyperglycaemic effect of Gynura procumbens
by: Wong, S.K., et al.
Published: (2015)

Anti-hyperglycaemic activity of the leaves of Tetracera Scandens Linn (dilleniaceae) in Alloxan induced diabetic male albino wistar rats
by: Ahmed, Qamar Uddin, et al.
Published: (2010)

Identification of alzheimer diseaseassociated pathways and network using transcriptome analysis / Lau Ching Yee
by: Lau , Ching Yee
Published: (2018)

Psychometric profile of Malaysian version of the Depressive, Anxiety and Stress Scale 42-item (DASS-42)
by: Musa, Ramli, et al.
Published: (2012)

42 pelajar sertai KEMPAS 2013
by: Berita Harian,
Published: (2013)

42 pelajar sertai KEMPAS 2013
by: Berita Harian,
Published: (2013)

Germinated brown rice alters Aβ(1-42) aggregation and modulates Alzheimer's disease-related genes in differentiated human SH-SY5Y cells
by: Azmi, Nur Hanisah, et al.
Published: (2015)

42 UMPSA graduands receive CBTM Diploma
by: Sakinah, Abdullah
Published: (2023)

42 staf UMP sertai bengkel kewartawanan
by: UMP, .
Published: (2010)

PERSADA, Bil.42, Jul-Sep 2012
by: Universiti Malaysia Sarawak, UNIMAS GLOBAL
Published: (2012)

42 graduan UMPSA terima Diploma CBTM
by: Sakinah, Abdullah
Published: (2023)

42 graduan UMPSA terima diploma CBTM
by: Norshahzura, Mat Zuki
Published: (2023)

The potential role of Peperomia pellucida (l.) Kunth in ameliorating hyperglycaemic and glycation-induced inflammation in human retinal pigment epithelial cell line (ARPE-19)
by: Ho, Keat Lam
Published: (2025)

Chronic Administration of Oil Palm (Elaeis guineensis ) Leaves Extract Attenuates Hyperglycaemic-Induced Oxidative Stress and Improves Renal Histopathology and Function in Experimental Diabetes
by: Rajavel, Varatharajan, et al.
Published: (2012)

Debt Trap, Debt Burden Shifting, And Welfare Loss: A Comparative Study On A Group Of Fourteen Asian Pacific Developing Countries
by: Noor Alam, Noor Alam
Published: (2007)

Potential role of JAK-STAT signaling pathway in the neurogenic-to-gliogenic shift in down syndrome brain
by: Lee, Han Chung, et al.
Published: (2016)

Phenotypic characterization of breast cancer: the role of CDC42
by: Chrysanthou, Eleni, et al.
Published: (2017)

Majlis Konvokesyen ke-42 Universiti Putra Malaysia
by: Universiti Putra Malaysia
Published: (2018)

UPM himpun 42 saintis fokus teknologi hijau
by: Berita Harian
Published: (2023)