Engineered AAV capsids mediate transduction of murine neurofibroma and sciatic nerve

QR Code

Engineered AAV capsids mediate transduction of murine neurofibroma and sciatic nerve

Genetic diseases such as Neurofibromatosis type 1 (NF1) and Charcot-Marie Tooth disease involve Schwann cells (SCs) associated with peripheral nerves. Gene therapy using adeno-associated virus (AAV) vector mediated gene delivery is a promising strategy to treat these diseases. However, AAV-mediated...

Full description

Bibliographic Details
Main Authors:	Abou Haidar, Edwina, Prabhakar, Shilpa, Cheah, Pike See, Hanlon, Killian S., Espinoza, Paula, Crain, Adam V., Patel, Nikita, Radcliff, Greta W., Cheng, Ming, Hernández, Iván Coto, Minderler, Steven, de la Cruz, Demitri, Ng, Carrie, da Hora, Cintia Carla, Charest, Alain, Stemmer-Rachamimov, Anat, Jowett, Nate, Breakefield, Xandra O., Maguire, Casey A.
Format:	Article
Language:	English
Published:	Springer Nature 2025
Online Access:	http://psasir.upm.edu.my/id/eprint/120712/ http://psasir.upm.edu.my/id/eprint/120712/1/120712.pdf

Similar Items

Long-term therapeutic efficacy of intravenous AAV-mediated hamartin replacement in mouse model of tuberous sclerosis type 1
by: Prabhakar, Shilpa, et al.
Published: (2019)

A rare presentation of plexiform neurofibroma
by: Poh, Khay Wei, et al.
Published: (2018)

Part A: Outlining the current state of AAVs & evaluating albumins potential role in AAV stability / Part B: Comparing separation resolution of multiple SEC columns & evaluating AAV-albumin interactions
by: Hughes, Oliver
Published: (2024)

Surgery for massive paediatric head and neck Neurofibroma: two case reports
by: Asha'ari, Zamzil Amin, et al.
Published: (2012)

Gene replacement therapy in a schwannoma mouse model of neurofibromatosis type 2
by: Prabhakar, Shilpa, et al.
Published: (2022)

Intravitreal application of AAV-BDNF or mutant AAV-CRMP2 protects retinal ganglion cells and stabilizes axons and myelin after partial optic nerve injury
by: Chiha, Wissam, et al.
Published: (2020)

Effect of protein A-immunoadsorption therapy on serum cytokines in AAV patients
by: Li, Xiejia, et al.
Published: (2022)

Sciatic nerve entrapment causing posterior knee pain
by: Zainol Fithri, Zairul Nizam, et al.
Published: (2005)

Iatrogenic sciatic nerve injury: a case report
by: Devaraj, Navin Kumar, et al.
Published: (2020)

Schwann cell-axon metabolic interactions of the mouse sciatic nerve
by: Rich, Laura
Published: (2017)

First results from AAVS 0.5: A prototype array for next-generation radio astronomy
by: Hall, Peter, et al.
Published: (2013)

Metabolic interactions between axons and Schwann cells of the mouse sciatic nerve
by: Rich, Laura
Published: (2022)

Effects of omental pedicle transposition on regeneration of neurotmesis sciatic nerve in rabbit
by: Al-Timmemi, Hameed A., et al.
Published: (2010)

Pressure pain thresholds of the sciatic, tibial and common peroneal nerves in asymptomatic subjects
by: Walsh, J., et al.
Published: (2010)

Fibre sub-type specific conduction reveals metabolic function in mouse sciatic nerve
by: Rich, Laura, et al.
Published: (2018)

Effect of Core Strengthening and Posture Correction Exercises with Stretching on Sciatic Nerve Root Compression
by: Nishitha, ., et al.
Published: (2023)

A Neurogenic Perspective of Sarcopenia: Time Course Study of Sciatic Nerves From Aging Mice
by: Krishnan, V., et al.
Published: (2016)

Neurobiological observations of bone mesenchymal stem cells in vitro and in vivo of injured sciatic nerve in rabbit
by: Al-Timmemi, Hameed A., et al.
Published: (2011)

Harvesting the maximum length of sciatic nerve from adult mice: a step-by-step approach
by: Bala, Usman, et al.
Published: (2014)

Effect of tocotrienol rich fraction (TRF) on muscles reinnervation after sciatic nerve crush injury in rats
by: Lailanor, Amalia, et al.
Published: (2020)

Inhibitory effects of Melicope ptelefolia extract on compound action potentials in frog sciatic nerves and its possible mechanism of action
by: Chia, Jasmine Siew Min, et al.
Published: (2019)

Inhibitory effects of Melicope ptelefolia extract on compound action potentials in frog sciatic nerves and its possible mechanism of action
by: Siew, Jasmine Min Chia, et al.
Published: (2019)

Cortical AAV-CNTF Gene Therapy Combined with Intraspinal Mesenchymal Precursor Cell Transplantation Promotes Functional and Morphological Outcomes after Spinal Cord Injury in Adult Rats
by: Hodgetts, S.I., et al.
Published: (2018)

Relibility, validity and diagnostic accuracy of palpation of the sciatic, tibial and common peroneal nerves in the examination of low back related leg pain
by: Walsh, J., et al.
Published: (2009)

Resistance wheel exercise from mid-life has minimal effect on sciatic nerves from old mice in which sarcopenia was prevented
by: Krishnan, V., et al.
Published: (2017)

Surgical, clinical and pathological comparison on the used of omental pedicle and bone marrow stroma cell therapy following sciatic nerve neurotmesis in rabbit model
by: Al-Timmemi, Hameed Ali
Published: (2011)

Sciatic nerve repair with tissue engineered nerve: olfactory ensheating cells seeded poly (lactic-co-glygolic acid) conduit in an animal model
by: Tan, Chen Wee, et al.
Published: (2013)

Teenage pregnancy and its health implications
by: Hayward, Greta
Published: (2011)

Impact of mid-life onset of resistance exercise on age-related morphological and molecular changes in sciatic nerves, associated with sarcopenia, in old male and female mice
by: Krishnan, V., et al.
Published: (2017)

Social support and anxiety in women with newly diagnosed breast cancer
by: Goh, Greta Miranda
Published: (1999)

The role and effect of service network actors on continuous service innovation: A case study in the business-to-business health sector
by: Lambourdiere, Edwina
Published: (2014)

Workplace enviroment factors influencing transfer of training in Sarawak Energy Berhad
by: Edwina, Mandak
Published: (2011)

Risk management in Indian Banking Sector
by: Rekhy, Nikita
Published: (2012)

Role of consumer referrals in decision making and their role in building online brand communities- Case study 50cycles.com
by: Khandelwal, Nikita
Published: (2011)

Characterisation of a novel microtubule inhibitor and its therapeutic potential
by: Dave, Nikita
Published: (2024)

Coaches' Interpersonal Behaviours and Athletes' Basic Psychological Need States: Refined Conceptualisation and Measurement Based on a Self-Determination Theory Perspective
by: Bhavsar, Nikita
Published: (2019)

A near peer review task for Japanese language learning / Hiroaki Umehara and Greta Gorsuch
by: Hiroaki, Umehara, et al.
Published: (2013)

Critical success factors for corporate social responsibility adoption in the Malaysian construction sector: a delphi study
by: Anat Anaqie, Zahidy
Published: (2021)

Writing the self: case studies in phenomenology and fiction
by: Venkatachalam, Shilpa
Published: (2007)

Assessment of ovarian reserve in women undergoing cystectomy for benign ovarian disease
by: Deb, Shilpa
Published: (2012)