Comparing the toxicity effect induced by Bisphenol A and Bisphenol S in the zebrafish model
Introduction: Bisphenol S (BPS) is structurally similar to bisphenol A (BPA), and with the shift from BPA to BPS in consumer products, knowledge of BPS's impact on human health remains limited. This study compares the toxicity of BPA and BPS in zebrafish embryos. The zebrafish embryo model, wit...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Dr Tarak Nath Podder Memorial Foundation
2025
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| Online Access: | http://psasir.upm.edu.my/id/eprint/120551/ http://psasir.upm.edu.my/id/eprint/120551/1/120551.pdf |
| _version_ | 1848868201741418496 |
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| author | Saad, Muhamad Fikri Shazlan Abdullah, Muhammad Nazrul Hakim Lim, Vuanghao Yong, Yoke Keong |
| author_facet | Saad, Muhamad Fikri Shazlan Abdullah, Muhammad Nazrul Hakim Lim, Vuanghao Yong, Yoke Keong |
| author_sort | Saad, Muhamad Fikri Shazlan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: Bisphenol S (BPS) is structurally similar to bisphenol A (BPA), and with the shift from BPA to BPS in consumer products, knowledge of BPS's impact on human health remains limited. This study compares the toxicity of BPA and BPS in zebrafish embryos. The zebrafish embryo model, with conserved vertebrate cardiac development and high sensitivity to environmental toxins, provides an ideal platform to evaluate the comparative safety of BPS. Methods: Zebrafish embryos were exposed to BPA and BPS at concentrations of 10 µM and 20 µM in 24-well plates. Mortality rates were assessed at 120 hours post-fertilisation (hpf). Hatching rates were evaluated at 72 and 96 hpf using a modified protocol. Cardiotoxicity was assessed by measuring heart rate and pericardial oedema at 96 hpf. Results and Discussion: Neither BPA nor BPS had a significant effect on mortality or hatching rates. In the cardiotoxicity assay, exposure to 10 µM BPA increased the heart rate, while 20 µM BPA significantly (p<0.05) reduced it. Both BPS concentrations did not significantly (p>0.05) affect the heart rate compared to the control. Pericardial oedema was observed in both BPA-treated groups (10 µM and 20 µM) but not in the BPS-treated groups. Conclusion: BPS exhibits lower toxicity than BPA with respect to mortality and cardiotoxicity in zebrafish embryos, although neither compound affected hatching rates. |
| first_indexed | 2025-11-15T14:48:38Z |
| format | Article |
| id | upm-120551 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:48:38Z |
| publishDate | 2025 |
| publisher | Dr Tarak Nath Podder Memorial Foundation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1205512025-10-06T02:16:40Z http://psasir.upm.edu.my/id/eprint/120551/ Comparing the toxicity effect induced by Bisphenol A and Bisphenol S in the zebrafish model Saad, Muhamad Fikri Shazlan Abdullah, Muhammad Nazrul Hakim Lim, Vuanghao Yong, Yoke Keong Introduction: Bisphenol S (BPS) is structurally similar to bisphenol A (BPA), and with the shift from BPA to BPS in consumer products, knowledge of BPS's impact on human health remains limited. This study compares the toxicity of BPA and BPS in zebrafish embryos. The zebrafish embryo model, with conserved vertebrate cardiac development and high sensitivity to environmental toxins, provides an ideal platform to evaluate the comparative safety of BPS. Methods: Zebrafish embryos were exposed to BPA and BPS at concentrations of 10 µM and 20 µM in 24-well plates. Mortality rates were assessed at 120 hours post-fertilisation (hpf). Hatching rates were evaluated at 72 and 96 hpf using a modified protocol. Cardiotoxicity was assessed by measuring heart rate and pericardial oedema at 96 hpf. Results and Discussion: Neither BPA nor BPS had a significant effect on mortality or hatching rates. In the cardiotoxicity assay, exposure to 10 µM BPA increased the heart rate, while 20 µM BPA significantly (p<0.05) reduced it. Both BPS concentrations did not significantly (p>0.05) affect the heart rate compared to the control. Pericardial oedema was observed in both BPA-treated groups (10 µM and 20 µM) but not in the BPS-treated groups. Conclusion: BPS exhibits lower toxicity than BPA with respect to mortality and cardiotoxicity in zebrafish embryos, although neither compound affected hatching rates. Dr Tarak Nath Podder Memorial Foundation 2025 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/120551/1/120551.pdf Saad, Muhamad Fikri Shazlan and Abdullah, Muhammad Nazrul Hakim and Lim, Vuanghao and Yong, Yoke Keong (2025) Comparing the toxicity effect induced by Bisphenol A and Bisphenol S in the zebrafish model. International Journal of Advancement in Life Sciences Research, 8 (3). pp. 112-120. ISSN 2581-4877 https://ijalsr.org/index.php/journal/article/view/635 10.31632/ijalsr.2025.v08i03.010 |
| spellingShingle | Saad, Muhamad Fikri Shazlan Abdullah, Muhammad Nazrul Hakim Lim, Vuanghao Yong, Yoke Keong Comparing the toxicity effect induced by Bisphenol A and Bisphenol S in the zebrafish model |
| title | Comparing the toxicity effect induced by Bisphenol A and Bisphenol S in the zebrafish model |
| title_full | Comparing the toxicity effect induced by Bisphenol A and Bisphenol S in the zebrafish model |
| title_fullStr | Comparing the toxicity effect induced by Bisphenol A and Bisphenol S in the zebrafish model |
| title_full_unstemmed | Comparing the toxicity effect induced by Bisphenol A and Bisphenol S in the zebrafish model |
| title_short | Comparing the toxicity effect induced by Bisphenol A and Bisphenol S in the zebrafish model |
| title_sort | comparing the toxicity effect induced by bisphenol a and bisphenol s in the zebrafish model |
| url | http://psasir.upm.edu.my/id/eprint/120551/ http://psasir.upm.edu.my/id/eprint/120551/ http://psasir.upm.edu.my/id/eprint/120551/ http://psasir.upm.edu.my/id/eprint/120551/1/120551.pdf |