The relationship between metabolic syndrome and environmental endocrine disruptors: a systematic review and meta-analysis
Metabolic syndrome (MetS) is considered to be an important factor leading to an increased risk of chronic non-communicable diseases. Studies have found that exposure to environmental endocrine disruptors (EEDs) is associated with MetS, but the relationship between the two is unclear. In order to cla...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025
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| Online Access: | http://psasir.upm.edu.my/id/eprint/120478/ http://psasir.upm.edu.my/id/eprint/120478/1/120478.pdf |
| _version_ | 1848868191618465792 |
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| author | Pan, Kai Xu, Jie Li, Feng Aris, Ahmad Zaharin Yu, Huawen Xu, Yuzhu He, Jie Wang, Chengxing Yu, Jie |
| author_facet | Pan, Kai Xu, Jie Li, Feng Aris, Ahmad Zaharin Yu, Huawen Xu, Yuzhu He, Jie Wang, Chengxing Yu, Jie |
| author_sort | Pan, Kai |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Metabolic syndrome (MetS) is considered to be an important factor leading to an increased risk of chronic non-communicable diseases. Studies have found that exposure to environmental endocrine disruptors (EEDs) is associated with MetS, but the relationship between the two is unclear. In order to clarify the relationship between the two, a systematic review and meta-analysis were conducted to investigate their association. We searched Web of Science databases, Embase, and PubMed. We then utilized I2 statistics to assess the literature heterogeneity and pooled the data using both fixed-effects model (I2 < 50%) and the random effects model (I2 > 50%) in accordance with the PRISMA guidelines. The results showed that exposure to perfluoroalkyl substances (PFASs) was associated to specific components of MetS, such as PFNA and “high waist circumference” (OR = 1.23, 95% CI: 1.10–1.38), and PFOA and “elevated blood pressure” (OR = 1.05, 95% CI: 1.01–1.08). Exposure to phthalates (PAEs) increases the risk of MetS, with MECPP (OR = 1.16, 95% CI: 1.04–1.29) being an example. Moreover, polychlorinated biphenyls (PCBs) (OR = 1.47, 95% CI: 1.13–1.93) and organochlorine pesticides (OCPs) (OR = 1.97, 95% CI: 1.33–2.90) showed a positive association with the MetS. This study reveals that EEDs are a risk factor for MetS, which provides new evidence for the relationship between population EEDs exposure and MetS. |
| first_indexed | 2025-11-15T14:48:28Z |
| format | Article |
| id | upm-120478 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:48:28Z |
| publishDate | 2025 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1204782025-10-02T07:37:04Z http://psasir.upm.edu.my/id/eprint/120478/ The relationship between metabolic syndrome and environmental endocrine disruptors: a systematic review and meta-analysis Pan, Kai Xu, Jie Li, Feng Aris, Ahmad Zaharin Yu, Huawen Xu, Yuzhu He, Jie Wang, Chengxing Yu, Jie Metabolic syndrome (MetS) is considered to be an important factor leading to an increased risk of chronic non-communicable diseases. Studies have found that exposure to environmental endocrine disruptors (EEDs) is associated with MetS, but the relationship between the two is unclear. In order to clarify the relationship between the two, a systematic review and meta-analysis were conducted to investigate their association. We searched Web of Science databases, Embase, and PubMed. We then utilized I2 statistics to assess the literature heterogeneity and pooled the data using both fixed-effects model (I2 < 50%) and the random effects model (I2 > 50%) in accordance with the PRISMA guidelines. The results showed that exposure to perfluoroalkyl substances (PFASs) was associated to specific components of MetS, such as PFNA and “high waist circumference” (OR = 1.23, 95% CI: 1.10–1.38), and PFOA and “elevated blood pressure” (OR = 1.05, 95% CI: 1.01–1.08). Exposure to phthalates (PAEs) increases the risk of MetS, with MECPP (OR = 1.16, 95% CI: 1.04–1.29) being an example. Moreover, polychlorinated biphenyls (PCBs) (OR = 1.47, 95% CI: 1.13–1.93) and organochlorine pesticides (OCPs) (OR = 1.97, 95% CI: 1.33–2.90) showed a positive association with the MetS. This study reveals that EEDs are a risk factor for MetS, which provides new evidence for the relationship between population EEDs exposure and MetS. Elsevier 2025 Article PeerReviewed text en cc_by_nc_nd_4 http://psasir.upm.edu.my/id/eprint/120478/1/120478.pdf Pan, Kai and Xu, Jie and Li, Feng and Aris, Ahmad Zaharin and Yu, Huawen and Xu, Yuzhu and He, Jie and Wang, Chengxing and Yu, Jie (2025) The relationship between metabolic syndrome and environmental endocrine disruptors: a systematic review and meta-analysis. iScience, 28 (7). art. no. 112907. pp. 1-23. ISSN 2589-0042 https://www.sciencedirect.com/science/article/pii/S258900422501168X?via%3Dihub 10.1016/j.isci.2025.112907 |
| spellingShingle | Pan, Kai Xu, Jie Li, Feng Aris, Ahmad Zaharin Yu, Huawen Xu, Yuzhu He, Jie Wang, Chengxing Yu, Jie The relationship between metabolic syndrome and environmental endocrine disruptors: a systematic review and meta-analysis |
| title | The relationship between metabolic syndrome and environmental endocrine disruptors: a systematic review and meta-analysis |
| title_full | The relationship between metabolic syndrome and environmental endocrine disruptors: a systematic review and meta-analysis |
| title_fullStr | The relationship between metabolic syndrome and environmental endocrine disruptors: a systematic review and meta-analysis |
| title_full_unstemmed | The relationship between metabolic syndrome and environmental endocrine disruptors: a systematic review and meta-analysis |
| title_short | The relationship between metabolic syndrome and environmental endocrine disruptors: a systematic review and meta-analysis |
| title_sort | relationship between metabolic syndrome and environmental endocrine disruptors: a systematic review and meta-analysis |
| url | http://psasir.upm.edu.my/id/eprint/120478/ http://psasir.upm.edu.my/id/eprint/120478/ http://psasir.upm.edu.my/id/eprint/120478/ http://psasir.upm.edu.my/id/eprint/120478/1/120478.pdf |