Preliminary coronary artery disease (CAD) case and control study of total homocysteine (Hcy), clinico-laboratory and aociodemographic profiling among respondents in Klang Valley, Malaysia
Introduction: Coronary artery disease (CAD) is a multifactorial pathogenesis ailment usually associated with hypertension, hyperlipidemia and dysregulated biochemical characteristics. Materials and methods: This case-control study analysed risk factors such as age, gender, ethnicity, BMI, SBP and DB...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Faculty of Medicine and Health Sciences, University Putra Malaysia
2024
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/120240/ http://psasir.upm.edu.my/id/eprint/120240/1/120240.pdf |
| _version_ | 1848868144889724928 |
|---|---|
| author | Ahmad, Zalinah Abang Yusuf, Dayang Sarah Yasmine Mohamed Yusof, Ahmad Khairuddin Md Razip, Nurliyana Najwa Osman, Malina Ismil, Fatin Izyan |
| author_facet | Ahmad, Zalinah Abang Yusuf, Dayang Sarah Yasmine Mohamed Yusof, Ahmad Khairuddin Md Razip, Nurliyana Najwa Osman, Malina Ismil, Fatin Izyan |
| author_sort | Ahmad, Zalinah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: Coronary artery disease (CAD) is a multifactorial pathogenesis ailment usually associated with hypertension, hyperlipidemia and dysregulated biochemical characteristics. Materials and methods: This case-control study analysed risk factors such as age, gender, ethnicity, BMI, SBP and DBP which have been linked to CAD. TC, TG, HDL, LDL, smoking status, exercise habit, obesity, family history of CVD and tHcy were also assessed to elucidate their association with CAD. Seventy-four respondents were diagnosed as CAD patients with angiography assessment at National Health Institute (NHI) Malaysia. Three hundreds and ten healthy respondents with no CAD signs or history were recruited from NHI, UPM and National Blood Bank (NBB). This study explores sociodemographic and clinico laboratory risk factors which contribute to the CAD conditions. Results: Individuals with CAD had an average age of 53.66 ± 7.904 years old, significantly different with non-CAD respondents average age (32.07 ± 10.080), p<0.05. Malays were found to be the highest prevalent ethnic of having CAD, followed by Indians and Chinese,with p-value <0.05. Respondents with CAD had significantly greater BMI (29.11 ± 3.660) kg/m2 and higher SBP (135.16 ± 7.406) mmHg with p<0.05 compared to non-CAD. Laboratory results for respondents with CAD displayed higher TC (5.025 ± 1.009) mmol/L, TG (1.696 ± 0.222) mmol/L, LDL ( 3.483 ± 0.350) mmol/L and total Hcy levels (9.807 ± 2.149) μmol/L with p-value<0.05. Conclusion: Current preliminary findings ascertained that respondents with CAD were associated withthe risk of age , ethnicity and biochemical characteristics that could be further investigated for future study. |
| first_indexed | 2025-11-15T14:47:44Z |
| format | Article |
| id | upm-120240 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:47:44Z |
| publishDate | 2024 |
| publisher | Faculty of Medicine and Health Sciences, University Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1202402025-09-29T02:37:55Z http://psasir.upm.edu.my/id/eprint/120240/ Preliminary coronary artery disease (CAD) case and control study of total homocysteine (Hcy), clinico-laboratory and aociodemographic profiling among respondents in Klang Valley, Malaysia Ahmad, Zalinah Abang Yusuf, Dayang Sarah Yasmine Mohamed Yusof, Ahmad Khairuddin Md Razip, Nurliyana Najwa Osman, Malina Ismil, Fatin Izyan Introduction: Coronary artery disease (CAD) is a multifactorial pathogenesis ailment usually associated with hypertension, hyperlipidemia and dysregulated biochemical characteristics. Materials and methods: This case-control study analysed risk factors such as age, gender, ethnicity, BMI, SBP and DBP which have been linked to CAD. TC, TG, HDL, LDL, smoking status, exercise habit, obesity, family history of CVD and tHcy were also assessed to elucidate their association with CAD. Seventy-four respondents were diagnosed as CAD patients with angiography assessment at National Health Institute (NHI) Malaysia. Three hundreds and ten healthy respondents with no CAD signs or history were recruited from NHI, UPM and National Blood Bank (NBB). This study explores sociodemographic and clinico laboratory risk factors which contribute to the CAD conditions. Results: Individuals with CAD had an average age of 53.66 ± 7.904 years old, significantly different with non-CAD respondents average age (32.07 ± 10.080), p<0.05. Malays were found to be the highest prevalent ethnic of having CAD, followed by Indians and Chinese,with p-value <0.05. Respondents with CAD had significantly greater BMI (29.11 ± 3.660) kg/m2 and higher SBP (135.16 ± 7.406) mmHg with p<0.05 compared to non-CAD. Laboratory results for respondents with CAD displayed higher TC (5.025 ± 1.009) mmol/L, TG (1.696 ± 0.222) mmol/L, LDL ( 3.483 ± 0.350) mmol/L and total Hcy levels (9.807 ± 2.149) μmol/L with p-value<0.05. Conclusion: Current preliminary findings ascertained that respondents with CAD were associated withthe risk of age , ethnicity and biochemical characteristics that could be further investigated for future study. Faculty of Medicine and Health Sciences, University Putra Malaysia 2024 Article PeerReviewed text en cc_by_4 http://psasir.upm.edu.my/id/eprint/120240/1/120240.pdf Ahmad, Zalinah and Abang Yusuf, Dayang Sarah Yasmine and Mohamed Yusof, Ahmad Khairuddin and Md Razip, Nurliyana Najwa and Osman, Malina and Ismil, Fatin Izyan (2024) Preliminary coronary artery disease (CAD) case and control study of total homocysteine (Hcy), clinico-laboratory and aociodemographic profiling among respondents in Klang Valley, Malaysia. Malaysian Journal of Medicine and Health Sciences, 20 (suppl.11). pp. 57-64. ISSN 1675-8544; eISSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/202412301823419_MJMHS_1516.pdf 10.47836/mjmhs20.s11.9 |
| spellingShingle | Ahmad, Zalinah Abang Yusuf, Dayang Sarah Yasmine Mohamed Yusof, Ahmad Khairuddin Md Razip, Nurliyana Najwa Osman, Malina Ismil, Fatin Izyan Preliminary coronary artery disease (CAD) case and control study of total homocysteine (Hcy), clinico-laboratory and aociodemographic profiling among respondents in Klang Valley, Malaysia |
| title | Preliminary coronary artery disease (CAD) case and control study of total homocysteine (Hcy), clinico-laboratory and aociodemographic profiling among respondents in Klang Valley, Malaysia |
| title_full | Preliminary coronary artery disease (CAD) case and control study of total homocysteine (Hcy), clinico-laboratory and aociodemographic profiling among respondents in Klang Valley, Malaysia |
| title_fullStr | Preliminary coronary artery disease (CAD) case and control study of total homocysteine (Hcy), clinico-laboratory and aociodemographic profiling among respondents in Klang Valley, Malaysia |
| title_full_unstemmed | Preliminary coronary artery disease (CAD) case and control study of total homocysteine (Hcy), clinico-laboratory and aociodemographic profiling among respondents in Klang Valley, Malaysia |
| title_short | Preliminary coronary artery disease (CAD) case and control study of total homocysteine (Hcy), clinico-laboratory and aociodemographic profiling among respondents in Klang Valley, Malaysia |
| title_sort | preliminary coronary artery disease (cad) case and control study of total homocysteine (hcy), clinico-laboratory and aociodemographic profiling among respondents in klang valley, malaysia |
| url | http://psasir.upm.edu.my/id/eprint/120240/ http://psasir.upm.edu.my/id/eprint/120240/ http://psasir.upm.edu.my/id/eprint/120240/ http://psasir.upm.edu.my/id/eprint/120240/1/120240.pdf |