MRI-ultrasound fusion targeted transperineal prostate biopsy under local anaesthesia ‒ patient-reported and biopsy outcomes: a single centre cohort study
Objective: To compare the tolerability and feasibility of transrectal(TR) versus transperineal (TP) routes for prostate biopsy under local anaesthesia(LA). To assess the functional outcome and the complication of both procedures. Methods. A prospective cohort observational study was performed on pat...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
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Bionika Media
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/119611/ |
| _version_ | 1848868017446846464 |
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| author | Mohd Ghani, Khairul Asri Jaharudin, Mohd Azrul Eimirul Khor Wei Shen, Vincent Yusof, Mohd Razaleigh Mohamad Sharin, Mohamad Fairuz Jagwani, Arvind Vashdev Lee, Fei Yee Lee, Christopher Kheng Siang Fahmy Ahmed, Omar Ahmed |
| author_facet | Mohd Ghani, Khairul Asri Jaharudin, Mohd Azrul Eimirul Khor Wei Shen, Vincent Yusof, Mohd Razaleigh Mohamad Sharin, Mohamad Fairuz Jagwani, Arvind Vashdev Lee, Fei Yee Lee, Christopher Kheng Siang Fahmy Ahmed, Omar Ahmed |
| author_sort | Mohd Ghani, Khairul Asri |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Objective: To compare the tolerability and feasibility of transrectal(TR) versus transperineal (TP) routes for prostate biopsy under local anaesthesia(LA). To assess the functional outcome and the complication of both procedures. Methods. A prospective cohort observational study was performed on patients who underwent prostate biopsy under LA. Visual Analogue Scale (VAS) was used during the procedure. International Prostate Symptoms Score (IPSS) and International Index of Erectile dysfunction (IIEF) were assessed before the procedure and in 14 days after the procedure. Complication for each procedure was recorded. Result. A total of 128 patients with 64 patients for each group underwent prostate biopsy by TP and TR under LA. TP targeted biopsy group had comparable pain scores to those who underwent the procedure using the TR routes. The median pain score for the TP group was 2 and TR was 3, (IQR=2, range 0–10 for both groups)with no significant pain difference between both groups (P=0.48). Furthermore, there was no significant difference in urinary function(p=0.68) and sexual function (p=0.19) between the two groups post-procedure. Both groups have similar rates of complications, with no significant difference observed. Urinary tract infection incidents that did occur were rare and did not significantly differ between the groups (p=0.21). None of the patients experienced sepsis postoperatively. AUR was reported in both groups, slightly higher with 9.4%(N=6) in the TP group and 6.3%(N=4) in the TR group however no significant difference(p=0.112) was noted. Haematuria is common in both groups with TP (66%) and TR (59%) but self-limiting with Clavien-Dindo grade I without significant difference (p=0.589). Conclusion. Our results showed that both Transperineal and transrectal approaches have similar toler-ability with no significant difference in functional outcome or complications. Further studies are mandatory to verify our results. |
| first_indexed | 2025-11-15T14:45:42Z |
| format | Article |
| id | upm-119611 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T14:45:42Z |
| publishDate | 2024 |
| publisher | Bionika Media |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1196112025-08-29T08:36:03Z http://psasir.upm.edu.my/id/eprint/119611/ MRI-ultrasound fusion targeted transperineal prostate biopsy under local anaesthesia ‒ patient-reported and biopsy outcomes: a single centre cohort study Mohd Ghani, Khairul Asri Jaharudin, Mohd Azrul Eimirul Khor Wei Shen, Vincent Yusof, Mohd Razaleigh Mohamad Sharin, Mohamad Fairuz Jagwani, Arvind Vashdev Lee, Fei Yee Lee, Christopher Kheng Siang Fahmy Ahmed, Omar Ahmed Objective: To compare the tolerability and feasibility of transrectal(TR) versus transperineal (TP) routes for prostate biopsy under local anaesthesia(LA). To assess the functional outcome and the complication of both procedures. Methods. A prospective cohort observational study was performed on patients who underwent prostate biopsy under LA. Visual Analogue Scale (VAS) was used during the procedure. International Prostate Symptoms Score (IPSS) and International Index of Erectile dysfunction (IIEF) were assessed before the procedure and in 14 days after the procedure. Complication for each procedure was recorded. Result. A total of 128 patients with 64 patients for each group underwent prostate biopsy by TP and TR under LA. TP targeted biopsy group had comparable pain scores to those who underwent the procedure using the TR routes. The median pain score for the TP group was 2 and TR was 3, (IQR=2, range 0–10 for both groups)with no significant pain difference between both groups (P=0.48). Furthermore, there was no significant difference in urinary function(p=0.68) and sexual function (p=0.19) between the two groups post-procedure. Both groups have similar rates of complications, with no significant difference observed. Urinary tract infection incidents that did occur were rare and did not significantly differ between the groups (p=0.21). None of the patients experienced sepsis postoperatively. AUR was reported in both groups, slightly higher with 9.4%(N=6) in the TP group and 6.3%(N=4) in the TR group however no significant difference(p=0.112) was noted. Haematuria is common in both groups with TP (66%) and TR (59%) but self-limiting with Clavien-Dindo grade I without significant difference (p=0.589). Conclusion. Our results showed that both Transperineal and transrectal approaches have similar toler-ability with no significant difference in functional outcome or complications. Further studies are mandatory to verify our results. Bionika Media 2024 Article PeerReviewed Mohd Ghani, Khairul Asri and Jaharudin, Mohd Azrul Eimirul and Khor Wei Shen, Vincent and Yusof, Mohd Razaleigh and Mohamad Sharin, Mohamad Fairuz and Jagwani, Arvind Vashdev and Lee, Fei Yee and Lee, Christopher Kheng Siang and Fahmy Ahmed, Omar Ahmed (2024) MRI-ultrasound fusion targeted transperineal prostate biopsy under local anaesthesia ‒ patient-reported and biopsy outcomes: a single centre cohort study. Urologiia, 2024 (4). pp. 87-92. ISSN 1728-2985; eISSN: 2414-9020 https://urologyjournal.ru/articles/id/45360 10.18565/urology.2024.4.87-92 |
| spellingShingle | Mohd Ghani, Khairul Asri Jaharudin, Mohd Azrul Eimirul Khor Wei Shen, Vincent Yusof, Mohd Razaleigh Mohamad Sharin, Mohamad Fairuz Jagwani, Arvind Vashdev Lee, Fei Yee Lee, Christopher Kheng Siang Fahmy Ahmed, Omar Ahmed MRI-ultrasound fusion targeted transperineal prostate biopsy under local anaesthesia ‒ patient-reported and biopsy outcomes: a single centre cohort study |
| title | MRI-ultrasound fusion targeted transperineal prostate biopsy under local anaesthesia ‒ patient-reported and biopsy outcomes: a single centre cohort study |
| title_full | MRI-ultrasound fusion targeted transperineal prostate biopsy under local anaesthesia ‒ patient-reported and biopsy outcomes: a single centre cohort study |
| title_fullStr | MRI-ultrasound fusion targeted transperineal prostate biopsy under local anaesthesia ‒ patient-reported and biopsy outcomes: a single centre cohort study |
| title_full_unstemmed | MRI-ultrasound fusion targeted transperineal prostate biopsy under local anaesthesia ‒ patient-reported and biopsy outcomes: a single centre cohort study |
| title_short | MRI-ultrasound fusion targeted transperineal prostate biopsy under local anaesthesia ‒ patient-reported and biopsy outcomes: a single centre cohort study |
| title_sort | mri-ultrasound fusion targeted transperineal prostate biopsy under local anaesthesia ‒ patient-reported and biopsy outcomes: a single centre cohort study |
| url | http://psasir.upm.edu.my/id/eprint/119611/ http://psasir.upm.edu.my/id/eprint/119611/ http://psasir.upm.edu.my/id/eprint/119611/ |