Angioimmunoblastic T-cell lymphoma (AITL): a rare entity, commonly misdiagnosed
Angioimmunoblastic T-cell lymphoma (AITL) presents a wide range of clinical and histopathological features, often resembling various reactive and neoplastic diseases. This similarity poses a challenge in making a definitive diag-nosis in many cases. Distinguishing the neoplastic T cells can be parti...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universiti Putra Malaysia
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/119497/ http://psasir.upm.edu.my/id/eprint/119497/1/119497.pdf |
| _version_ | 1848867983773925376 |
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| author | Seman, Zainina Omar, Mohd. Shah Fazly Mohd Tajuddin, Syirah Nazirah |
| author_facet | Seman, Zainina Omar, Mohd. Shah Fazly Mohd Tajuddin, Syirah Nazirah |
| author_sort | Seman, Zainina |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Angioimmunoblastic T-cell lymphoma (AITL) presents a wide range of clinical and histopathological features, often resembling various reactive and neoplastic diseases. This similarity poses a challenge in making a definitive diag-nosis in many cases. Distinguishing the neoplastic T cells can be particularly difficult since they typically constitute a small proportion of the overall cellular infiltration. The tumour and inflammatory cells exhibit polymorphism and variable proportions. Additionally, the concurrent proliferation of B cells can mimic both reactive and neoplastic conditions. Furthermore, the atypical B cells may resemble Reed-Sternberg cells and show positivity for CD30 and CD15, often leading to misdiagnosis as classical Hodgkin lymphoma. In this case report, we present the case of a 65-year-old man initially diagnosed with classical Hodgkin lymphoma who underwent ABVD chemotherapy. Upon experiencing symptoms of disease relapse, the diagnosis was revised to AITL. |
| first_indexed | 2025-11-15T14:45:10Z |
| format | Article |
| id | upm-119497 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:45:10Z |
| publishDate | 2024 |
| publisher | Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1194972025-08-26T07:09:43Z http://psasir.upm.edu.my/id/eprint/119497/ Angioimmunoblastic T-cell lymphoma (AITL): a rare entity, commonly misdiagnosed Seman, Zainina Omar, Mohd. Shah Fazly Mohd Tajuddin, Syirah Nazirah Angioimmunoblastic T-cell lymphoma (AITL) presents a wide range of clinical and histopathological features, often resembling various reactive and neoplastic diseases. This similarity poses a challenge in making a definitive diag-nosis in many cases. Distinguishing the neoplastic T cells can be particularly difficult since they typically constitute a small proportion of the overall cellular infiltration. The tumour and inflammatory cells exhibit polymorphism and variable proportions. Additionally, the concurrent proliferation of B cells can mimic both reactive and neoplastic conditions. Furthermore, the atypical B cells may resemble Reed-Sternberg cells and show positivity for CD30 and CD15, often leading to misdiagnosis as classical Hodgkin lymphoma. In this case report, we present the case of a 65-year-old man initially diagnosed with classical Hodgkin lymphoma who underwent ABVD chemotherapy. Upon experiencing symptoms of disease relapse, the diagnosis was revised to AITL. Universiti Putra Malaysia 2024 Article PeerReviewed text en cc_by_4 http://psasir.upm.edu.my/id/eprint/119497/1/119497.pdf Seman, Zainina and Omar, Mohd. Shah Fazly and Mohd Tajuddin, Syirah Nazirah (2024) Angioimmunoblastic T-cell lymphoma (AITL): a rare entity, commonly misdiagnosed. Malaysian Journal of Medicine and Health Sciences, 20 (suppl.11). pp. 92-95. ISSN 1675-8544; eISSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2024123018302617_MJMHS_0723.pdf 10.47836/mjmhs20.s11.17 |
| spellingShingle | Seman, Zainina Omar, Mohd. Shah Fazly Mohd Tajuddin, Syirah Nazirah Angioimmunoblastic T-cell lymphoma (AITL): a rare entity, commonly misdiagnosed |
| title | Angioimmunoblastic T-cell lymphoma (AITL): a rare entity, commonly misdiagnosed |
| title_full | Angioimmunoblastic T-cell lymphoma (AITL): a rare entity, commonly misdiagnosed |
| title_fullStr | Angioimmunoblastic T-cell lymphoma (AITL): a rare entity, commonly misdiagnosed |
| title_full_unstemmed | Angioimmunoblastic T-cell lymphoma (AITL): a rare entity, commonly misdiagnosed |
| title_short | Angioimmunoblastic T-cell lymphoma (AITL): a rare entity, commonly misdiagnosed |
| title_sort | angioimmunoblastic t-cell lymphoma (aitl): a rare entity, commonly misdiagnosed |
| url | http://psasir.upm.edu.my/id/eprint/119497/ http://psasir.upm.edu.my/id/eprint/119497/ http://psasir.upm.edu.my/id/eprint/119497/ http://psasir.upm.edu.my/id/eprint/119497/1/119497.pdf |