Angioimmunoblastic T-cell lymphoma (AITL): a rare entity, commonly misdiagnosed
Angioimmunoblastic T-cell lymphoma (AITL) presents a wide range of clinical and histopathological features, often resembling various reactive and neoplastic diseases. This similarity poses a challenge in making a definitive diag-nosis in many cases. Distinguishing the neoplastic T cells can be parti...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universiti Putra Malaysia
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/119497/ http://psasir.upm.edu.my/id/eprint/119497/1/119497.pdf |
| Summary: | Angioimmunoblastic T-cell lymphoma (AITL) presents a wide range of clinical and histopathological features, often resembling various reactive and neoplastic diseases. This similarity poses a challenge in making a definitive diag-nosis in many cases. Distinguishing the neoplastic T cells can be particularly difficult since they typically constitute a small proportion of the overall cellular infiltration. The tumour and inflammatory cells exhibit polymorphism and variable proportions. Additionally, the concurrent proliferation of B cells can mimic both reactive and neoplastic conditions. Furthermore, the atypical B cells may resemble Reed-Sternberg cells and show positivity for CD30 and CD15, often leading to misdiagnosis as classical Hodgkin lymphoma. In this case report, we present the case of a 65-year-old man initially diagnosed with classical Hodgkin lymphoma who underwent ABVD chemotherapy. Upon experiencing symptoms of disease relapse, the diagnosis was revised to AITL. |
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