A review of animal models for studying bone health in type-2 diabetes mellitus (T2DM) and obesity
Preclinical research on diabetes and obesity has been carried out in various animal models over the years. These animal models are developed from genetic manipulation that affects their body metabolism, chemical-induced procedures, diet alteration/modifications, or combinations of the aforementioned...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Multidisciplinary Digital Publishing Institute (MDPI)
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/119389/ http://psasir.upm.edu.my/id/eprint/119389/1/119389.pdf |
| _version_ | 1848867951583690752 |
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| author | Norazman, Saiful Iqbal Mohd Zaffarin, Anis Syauqina Shuid, Ahmad Nazrun Hassan, Haniza Soleiman, Ima Nirwana Kuan, Wong Sok Alias, Ekram |
| author_facet | Norazman, Saiful Iqbal Mohd Zaffarin, Anis Syauqina Shuid, Ahmad Nazrun Hassan, Haniza Soleiman, Ima Nirwana Kuan, Wong Sok Alias, Ekram |
| author_sort | Norazman, Saiful Iqbal |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Preclinical research on diabetes and obesity has been carried out in various animal models over the years. These animal models are developed from genetic manipulation that affects their body metabolism, chemical-induced procedures, diet alteration/modifications, or combinations of the aforementioned approaches. The diabetic and obesity animal models have allowed researchers to not only study the pathological aspect of the diseases but also enable them to screen and explore potential therapeutic compounds. Besides several widely known complications such as macrovascular diseases, diabetic neuropathy, nephropathy and retinopathy, type 2 diabetes mellitus is also known to affect bone health. There is also evidence to suggest obesity affects bone health. Therefore, continuous research needs to be conducted to find a remedy or solution to this matter. Previous literature reported evidence of bone loss in animal models of diabetes and obesity. These findings, as highlighted in this review, further augment the suggestion of an inter-relationship between diabetes, obesity and bone loss. |
| first_indexed | 2025-11-15T14:44:39Z |
| format | Article |
| id | upm-119389 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:44:39Z |
| publishDate | 2024 |
| publisher | Multidisciplinary Digital Publishing Institute (MDPI) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1193892025-08-19T02:26:13Z http://psasir.upm.edu.my/id/eprint/119389/ A review of animal models for studying bone health in type-2 diabetes mellitus (T2DM) and obesity Norazman, Saiful Iqbal Mohd Zaffarin, Anis Syauqina Shuid, Ahmad Nazrun Hassan, Haniza Soleiman, Ima Nirwana Kuan, Wong Sok Alias, Ekram Preclinical research on diabetes and obesity has been carried out in various animal models over the years. These animal models are developed from genetic manipulation that affects their body metabolism, chemical-induced procedures, diet alteration/modifications, or combinations of the aforementioned approaches. The diabetic and obesity animal models have allowed researchers to not only study the pathological aspect of the diseases but also enable them to screen and explore potential therapeutic compounds. Besides several widely known complications such as macrovascular diseases, diabetic neuropathy, nephropathy and retinopathy, type 2 diabetes mellitus is also known to affect bone health. There is also evidence to suggest obesity affects bone health. Therefore, continuous research needs to be conducted to find a remedy or solution to this matter. Previous literature reported evidence of bone loss in animal models of diabetes and obesity. These findings, as highlighted in this review, further augment the suggestion of an inter-relationship between diabetes, obesity and bone loss. Multidisciplinary Digital Publishing Institute (MDPI) 2024-08-29 Article PeerReviewed text en cc_by_4 http://psasir.upm.edu.my/id/eprint/119389/1/119389.pdf Norazman, Saiful Iqbal and Mohd Zaffarin, Anis Syauqina and Shuid, Ahmad Nazrun and Hassan, Haniza and Soleiman, Ima Nirwana and Kuan, Wong Sok and Alias, Ekram (2024) A review of animal models for studying bone health in type-2 diabetes mellitus (T2DM) and obesity. International Journal of Molecular Sciences, 25 (17). art. no. 9399. pp. 1-23. ISSN 1661-6596; eISSN: 1422-0067 https://www.mdpi.com/1422-0067/25/17/9399 10.3390/ijms25179399 |
| spellingShingle | Norazman, Saiful Iqbal Mohd Zaffarin, Anis Syauqina Shuid, Ahmad Nazrun Hassan, Haniza Soleiman, Ima Nirwana Kuan, Wong Sok Alias, Ekram A review of animal models for studying bone health in type-2 diabetes mellitus (T2DM) and obesity |
| title | A review of animal models for studying bone health in type-2 diabetes mellitus (T2DM) and obesity |
| title_full | A review of animal models for studying bone health in type-2 diabetes mellitus (T2DM) and obesity |
| title_fullStr | A review of animal models for studying bone health in type-2 diabetes mellitus (T2DM) and obesity |
| title_full_unstemmed | A review of animal models for studying bone health in type-2 diabetes mellitus (T2DM) and obesity |
| title_short | A review of animal models for studying bone health in type-2 diabetes mellitus (T2DM) and obesity |
| title_sort | review of animal models for studying bone health in type-2 diabetes mellitus (t2dm) and obesity |
| url | http://psasir.upm.edu.my/id/eprint/119389/ http://psasir.upm.edu.my/id/eprint/119389/ http://psasir.upm.edu.my/id/eprint/119389/ http://psasir.upm.edu.my/id/eprint/119389/1/119389.pdf |