Harnessing monoterpenes and monoterpenoids as weapons against antimicrobial resistance
Antimicrobial resistance (AMR) poses a formidable challenge in global healthcare, driving the exploration of natural products for novel antimicrobials. Among these, essential oils (EOs) derived from medicinal plants are rich sources of diverse bioactive compounds. Monoterpenes and monoterpenoids, cr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2025
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| Online Access: | http://psasir.upm.edu.my/id/eprint/119143/ http://psasir.upm.edu.my/id/eprint/119143/1/119143.pdf |
| _version_ | 1848867885656571904 |
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| author | Kong, Amanda Shen-Yee Lim, Swee-Hua Erin Cheng, Wan-Hee Yuswan, Mohd Hafis Tan, Ngai-Paing Lai, Kok-Song |
| author_facet | Kong, Amanda Shen-Yee Lim, Swee-Hua Erin Cheng, Wan-Hee Yuswan, Mohd Hafis Tan, Ngai-Paing Lai, Kok-Song |
| author_sort | Kong, Amanda Shen-Yee |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Antimicrobial resistance (AMR) poses a formidable challenge in global healthcare, driving the exploration of natural products for novel antimicrobials. Among these, essential oils (EOs) derived from medicinal plants are rich sources of diverse bioactive compounds. Monoterpenes and monoterpenoids, critical constituents of EOs, have emerged as promising agents in combating multidrugresistant (MDR) pathogens. This review analyzed recent literature on the efficacy of monoterpenes against AMR, highlighting their broad-spectrum activity and potential as alternative therapeutic options for MDR infections. Mechanistic insights reveal their ability to disrupt cell membranes, inhibit biofilm formation, and modulate gene expression linked to virulence and resistance, thereby reducing microbial viability through alterations in membrane potential, enzymatic activity, and genetic regulation. Synergistic interactions between monoterpenes and conventional antibiotics are also elucidated. Innovative approaches in monoterpene research are explored, although challenges such as resistance, limited solubility, volatility, and potential toxicity are acknowledged, emphasizing the need for advanced formulation strategies and interdisciplinary research. The synergy observed with conventional antibiotics, coupled with their ability to target specific microbial resistance mechanisms, underscores the potential of monoterpenes in combating antibioticresistant infections. Future investigations should prioritize optimizing monoterpenes' therapeutic properties and assessing their safety profiles to fully exploit their potential in addressing AMR. |
| first_indexed | 2025-11-15T14:43:36Z |
| format | Article |
| id | upm-119143 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:43:36Z |
| publishDate | 2025 |
| publisher | Sciendo |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1191432025-08-06T07:59:03Z http://psasir.upm.edu.my/id/eprint/119143/ Harnessing monoterpenes and monoterpenoids as weapons against antimicrobial resistance Kong, Amanda Shen-Yee Lim, Swee-Hua Erin Cheng, Wan-Hee Yuswan, Mohd Hafis Tan, Ngai-Paing Lai, Kok-Song Antimicrobial resistance (AMR) poses a formidable challenge in global healthcare, driving the exploration of natural products for novel antimicrobials. Among these, essential oils (EOs) derived from medicinal plants are rich sources of diverse bioactive compounds. Monoterpenes and monoterpenoids, critical constituents of EOs, have emerged as promising agents in combating multidrugresistant (MDR) pathogens. This review analyzed recent literature on the efficacy of monoterpenes against AMR, highlighting their broad-spectrum activity and potential as alternative therapeutic options for MDR infections. Mechanistic insights reveal their ability to disrupt cell membranes, inhibit biofilm formation, and modulate gene expression linked to virulence and resistance, thereby reducing microbial viability through alterations in membrane potential, enzymatic activity, and genetic regulation. Synergistic interactions between monoterpenes and conventional antibiotics are also elucidated. Innovative approaches in monoterpene research are explored, although challenges such as resistance, limited solubility, volatility, and potential toxicity are acknowledged, emphasizing the need for advanced formulation strategies and interdisciplinary research. The synergy observed with conventional antibiotics, coupled with their ability to target specific microbial resistance mechanisms, underscores the potential of monoterpenes in combating antibioticresistant infections. Future investigations should prioritize optimizing monoterpenes' therapeutic properties and assessing their safety profiles to fully exploit their potential in addressing AMR. Sciendo 2025 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/119143/1/119143.pdf Kong, Amanda Shen-Yee and Lim, Swee-Hua Erin and Cheng, Wan-Hee and Yuswan, Mohd Hafis and Tan, Ngai-Paing and Lai, Kok-Song (2025) Harnessing monoterpenes and monoterpenoids as weapons against antimicrobial resistance. Polish Journal of Microbiology, 74 (1). pp. 1-18. ISSN 1733-1331; eISSN: 2544-4646 https://sciendo.com/article/10.33073/pjm-2025-010 10.33073/pjm-2025-010 |
| spellingShingle | Kong, Amanda Shen-Yee Lim, Swee-Hua Erin Cheng, Wan-Hee Yuswan, Mohd Hafis Tan, Ngai-Paing Lai, Kok-Song Harnessing monoterpenes and monoterpenoids as weapons against antimicrobial resistance |
| title | Harnessing monoterpenes and monoterpenoids as weapons against antimicrobial resistance |
| title_full | Harnessing monoterpenes and monoterpenoids as weapons against antimicrobial resistance |
| title_fullStr | Harnessing monoterpenes and monoterpenoids as weapons against antimicrobial resistance |
| title_full_unstemmed | Harnessing monoterpenes and monoterpenoids as weapons against antimicrobial resistance |
| title_short | Harnessing monoterpenes and monoterpenoids as weapons against antimicrobial resistance |
| title_sort | harnessing monoterpenes and monoterpenoids as weapons against antimicrobial resistance |
| url | http://psasir.upm.edu.my/id/eprint/119143/ http://psasir.upm.edu.my/id/eprint/119143/ http://psasir.upm.edu.my/id/eprint/119143/ http://psasir.upm.edu.my/id/eprint/119143/1/119143.pdf |