Nephrotic syndrome in young adolescent
CASE PRESENTATION: A 13-year-old female presented with a one-week history of bilateral lower limb swelling associated with cough and sore throat. There was no fever, breathlessness, hematuria, or frothy urine. She denied connective tissue disease-related symptoms. There was also no family histo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Malaysian Society Of Nephrology
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/119072/ http://psasir.upm.edu.my/id/eprint/119072/1/119072.pdf |
| Summary: | CASE PRESENTATION: A 13-year-old female presented with a one-week history
of bilateral lower limb swelling associated with cough
and sore throat. There was no fever, breathlessness,
hematuria, or frothy urine. She denied connective tissue
disease-related symptoms. There was also no family
history of autoimmune disease or chronic kidney disease.
On examination, her blood pressure was 135/91 mmHg
with conjunctival pallor and lower limb pitting oedema.
Her initial investigation showed haemoglobin of 9g/dL,
LDH 390U/L, positive Coombs test with IgG 2+ and
C3D 3+, and peripheral blood film showed spherocytes
with no schistocytes or agglutination. Her creatinine was
40 μmol/L, urine protein 4+ blood 1+, 24-hour urinary
protein of 7.4g/day and low albumin of 20g/dL. Her viral
screening was non-reactive, and an immunology workup
revealed negative ANA with normal C3 and C4 levels as
well as negative ASOT. |
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