Engineered mesenchymal stem cells as treatment for cancers: opportunities, clinical applications and challenges
The insufficient and unspecific target of classical chemotherapies often leads to therapy resistance and cancer recurrence. Over the past decades, discoveries about mesenchymal stem cell (MSC) biology have provided new potential approaches to improve cancer therapy. Researchers have utilised the mul...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Sains Malaysia
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/118988/ http://psasir.upm.edu.my/id/eprint/118988/1/118988.pdf |
| _version_ | 1848867842145910784 |
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| author | Shamsul Kamal, Aishah Amirah Fakiruddin, Kamal Shaik Abubakar Bobbo, Khadijat King, Hwa Ling Vidyadaran, Sharmili Abdullah, Syahril |
| author_facet | Shamsul Kamal, Aishah Amirah Fakiruddin, Kamal Shaik Abubakar Bobbo, Khadijat King, Hwa Ling Vidyadaran, Sharmili Abdullah, Syahril |
| author_sort | Shamsul Kamal, Aishah Amirah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The insufficient and unspecific target of classical chemotherapies often leads to therapy resistance and cancer recurrence. Over the past decades, discoveries about mesenchymal stem cell (MSC) biology have provided new potential approaches to improve cancer therapy. Researchers have utilised the multipotent, regenerative and immunosuppressive qualities of MSCs and tropisms towards inflammatory, hypoxic and malignant sites in various therapeutic applications. Although MSC-based therapies have generally been demonstrated safe, their effectiveness remains limited when these cells are used alone. However, through genetic engineering, researchers have proven that MSCs can be modified to have specialised delivery roles to increase their therapeutic efficacy in cancer treatment. They can be made to overexpress therapeutic proteins through viral or non-viral genetic modification, which enhances their innate properties. Nevertheless, these engineering strategies must be optimised to increase therapeutic efficacy and targeting effectiveness while minimising any loss of MSC function. This review underscores the cutting-edge methods for engineering MSCs, discusses their promise and the difficulties in translating them into clinical settings, and offers some prospective suggestions for the future on achieving their full therapeutic potential. |
| first_indexed | 2025-11-15T14:42:55Z |
| format | Article |
| id | upm-118988 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:42:55Z |
| publishDate | 2024 |
| publisher | Penerbit Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1189882025-07-31T09:13:11Z http://psasir.upm.edu.my/id/eprint/118988/ Engineered mesenchymal stem cells as treatment for cancers: opportunities, clinical applications and challenges Shamsul Kamal, Aishah Amirah Fakiruddin, Kamal Shaik Abubakar Bobbo, Khadijat King, Hwa Ling Vidyadaran, Sharmili Abdullah, Syahril The insufficient and unspecific target of classical chemotherapies often leads to therapy resistance and cancer recurrence. Over the past decades, discoveries about mesenchymal stem cell (MSC) biology have provided new potential approaches to improve cancer therapy. Researchers have utilised the multipotent, regenerative and immunosuppressive qualities of MSCs and tropisms towards inflammatory, hypoxic and malignant sites in various therapeutic applications. Although MSC-based therapies have generally been demonstrated safe, their effectiveness remains limited when these cells are used alone. However, through genetic engineering, researchers have proven that MSCs can be modified to have specialised delivery roles to increase their therapeutic efficacy in cancer treatment. They can be made to overexpress therapeutic proteins through viral or non-viral genetic modification, which enhances their innate properties. Nevertheless, these engineering strategies must be optimised to increase therapeutic efficacy and targeting effectiveness while minimising any loss of MSC function. This review underscores the cutting-edge methods for engineering MSCs, discusses their promise and the difficulties in translating them into clinical settings, and offers some prospective suggestions for the future on achieving their full therapeutic potential. Penerbit Universiti Sains Malaysia 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/118988/1/118988.pdf Shamsul Kamal, Aishah Amirah and Fakiruddin, Kamal Shaik and Abubakar Bobbo, Khadijat and King, Hwa Ling and Vidyadaran, Sharmili and Abdullah, Syahril (2024) Engineered mesenchymal stem cells as treatment for cancers: opportunities, clinical applications and challenges. Malaysian Journal of Medical Sciences, 31 (5). pp. 56-82. ISSN 1394-195X; eISSN: 2180-4303 http://www.mjms.usm.my/MJMS31052024/MJMS31052024_05.pdf 10.21315/mjms2024.31.5.5 |
| spellingShingle | Shamsul Kamal, Aishah Amirah Fakiruddin, Kamal Shaik Abubakar Bobbo, Khadijat King, Hwa Ling Vidyadaran, Sharmili Abdullah, Syahril Engineered mesenchymal stem cells as treatment for cancers: opportunities, clinical applications and challenges |
| title | Engineered mesenchymal stem cells as treatment for cancers: opportunities, clinical applications and challenges |
| title_full | Engineered mesenchymal stem cells as treatment for cancers: opportunities, clinical applications and challenges |
| title_fullStr | Engineered mesenchymal stem cells as treatment for cancers: opportunities, clinical applications and challenges |
| title_full_unstemmed | Engineered mesenchymal stem cells as treatment for cancers: opportunities, clinical applications and challenges |
| title_short | Engineered mesenchymal stem cells as treatment for cancers: opportunities, clinical applications and challenges |
| title_sort | engineered mesenchymal stem cells as treatment for cancers: opportunities, clinical applications and challenges |
| url | http://psasir.upm.edu.my/id/eprint/118988/ http://psasir.upm.edu.my/id/eprint/118988/ http://psasir.upm.edu.my/id/eprint/118988/ http://psasir.upm.edu.my/id/eprint/118988/1/118988.pdf |