Centella asiatica ameliorates AlCl3 and D-galactose induced nephrotoxicity in rats via modulation of oxidative stress
Nephrotoxicity is a condition caused by toxic effects of medications and poisons resulting in the rapid decline of kidney function. Centella asiatica is a medicinal herb with antioxidative and anti-inflammatory characteristics that is used to treat a variety of ailments. The present study intends to...
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| Format: | Article |
| Language: | English |
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Biomedical Informatics
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/118938/ http://psasir.upm.edu.my/id/eprint/118938/1/118938.pdf |
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| author | Vishnumukkala, Thirupathirao Gopalakrishna, Prarthana Kalerammana Karikalan, Barani Thomas, Warren Jagadeesan, Saravanan Musa Chiroma, Samaila Mohd Nor, Nurul Huda Mohd Moklas, Mohamad Aris |
| author_facet | Vishnumukkala, Thirupathirao Gopalakrishna, Prarthana Kalerammana Karikalan, Barani Thomas, Warren Jagadeesan, Saravanan Musa Chiroma, Samaila Mohd Nor, Nurul Huda Mohd Moklas, Mohamad Aris |
| author_sort | Vishnumukkala, Thirupathirao |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Nephrotoxicity is a condition caused by toxic effects of medications and poisons resulting in the rapid decline of kidney function. Centella asiatica is a medicinal herb with antioxidative and anti-inflammatory characteristics that is used to treat a variety of ailments. The present study intends to explore the ability of Centella asiatica in preventing AlCl3 and D-Galactose-induced nephrotoxicity in rats. In this study 30 male albino Wistar rats were induced with nephrotoxicity using AlCl3 and D-galactose, and oral administration of Centella asiatica extract (100, 200, and 300mg/kg/day) was administered for 70 days. The kidneys were extracted after treatment and levels of oxidative and antioxidative enzymes, serum creatinine, and serum albumin were measured. The kidney's histopathological changes were studied. Administration of Centella asiatica extract significantly increased serum albumin, superoxide dismutase (SOD), and catalase levels in kidney homogenates while suppressing serum creatinine and malondialdehyde (MDA) levels and attenuating histopathological changes associated with nephrotoxicity. Centella asiatica extract lowered serum creatinine and oxidative stress levels in a drug-induced nephrotoxicity rat model, while simultaneously increasing serum albumin levels, as evidenced by mitigation of histological changes and normalisation of biomarkers of oxidative stress in the kidney. |
| first_indexed | 2025-11-15T14:42:42Z |
| format | Article |
| id | upm-118938 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:42:42Z |
| publishDate | 2024 |
| publisher | Biomedical Informatics |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1189382025-07-30T02:09:54Z http://psasir.upm.edu.my/id/eprint/118938/ Centella asiatica ameliorates AlCl3 and D-galactose induced nephrotoxicity in rats via modulation of oxidative stress Vishnumukkala, Thirupathirao Gopalakrishna, Prarthana Kalerammana Karikalan, Barani Thomas, Warren Jagadeesan, Saravanan Musa Chiroma, Samaila Mohd Nor, Nurul Huda Mohd Moklas, Mohamad Aris Nephrotoxicity is a condition caused by toxic effects of medications and poisons resulting in the rapid decline of kidney function. Centella asiatica is a medicinal herb with antioxidative and anti-inflammatory characteristics that is used to treat a variety of ailments. The present study intends to explore the ability of Centella asiatica in preventing AlCl3 and D-Galactose-induced nephrotoxicity in rats. In this study 30 male albino Wistar rats were induced with nephrotoxicity using AlCl3 and D-galactose, and oral administration of Centella asiatica extract (100, 200, and 300mg/kg/day) was administered for 70 days. The kidneys were extracted after treatment and levels of oxidative and antioxidative enzymes, serum creatinine, and serum albumin were measured. The kidney's histopathological changes were studied. Administration of Centella asiatica extract significantly increased serum albumin, superoxide dismutase (SOD), and catalase levels in kidney homogenates while suppressing serum creatinine and malondialdehyde (MDA) levels and attenuating histopathological changes associated with nephrotoxicity. Centella asiatica extract lowered serum creatinine and oxidative stress levels in a drug-induced nephrotoxicity rat model, while simultaneously increasing serum albumin levels, as evidenced by mitigation of histological changes and normalisation of biomarkers of oxidative stress in the kidney. Biomedical Informatics 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/118938/1/118938.pdf Vishnumukkala, Thirupathirao and Gopalakrishna, Prarthana Kalerammana and Karikalan, Barani and Thomas, Warren and Jagadeesan, Saravanan and Musa Chiroma, Samaila and Mohd Nor, Nurul Huda and Mohd Moklas, Mohamad Aris (2024) Centella asiatica ameliorates AlCl3 and D-galactose induced nephrotoxicity in rats via modulation of oxidative stress. Bioinformation, 20 (5). pp. 508-514. ISSN 0973-2063 https://www.bioinformation.net/020/973206300200508.htm 10.6026/973206300200508 |
| spellingShingle | Vishnumukkala, Thirupathirao Gopalakrishna, Prarthana Kalerammana Karikalan, Barani Thomas, Warren Jagadeesan, Saravanan Musa Chiroma, Samaila Mohd Nor, Nurul Huda Mohd Moklas, Mohamad Aris Centella asiatica ameliorates AlCl3 and D-galactose induced nephrotoxicity in rats via modulation of oxidative stress |
| title | Centella asiatica ameliorates AlCl3 and D-galactose induced nephrotoxicity in rats via modulation of oxidative stress |
| title_full | Centella asiatica ameliorates AlCl3 and D-galactose induced nephrotoxicity in rats via modulation of oxidative stress |
| title_fullStr | Centella asiatica ameliorates AlCl3 and D-galactose induced nephrotoxicity in rats via modulation of oxidative stress |
| title_full_unstemmed | Centella asiatica ameliorates AlCl3 and D-galactose induced nephrotoxicity in rats via modulation of oxidative stress |
| title_short | Centella asiatica ameliorates AlCl3 and D-galactose induced nephrotoxicity in rats via modulation of oxidative stress |
| title_sort | centella asiatica ameliorates alcl3 and d-galactose induced nephrotoxicity in rats via modulation of oxidative stress |
| url | http://psasir.upm.edu.my/id/eprint/118938/ http://psasir.upm.edu.my/id/eprint/118938/ http://psasir.upm.edu.my/id/eprint/118938/ http://psasir.upm.edu.my/id/eprint/118938/1/118938.pdf |