Proposed molecular mechanism of non-competitive inhibition using molecular dynamics simulations between α-glucosidase enzyme and mangostin compound as antidiabetic
Context: Further understanding of the molecular mechanisms is necessary since it is important for designing new drugs. This study aimed to understand the molecular mechanisms involved in the design of drugs that are inhibitors of the α-glucosidase enzyme. This research aims to gain further understan...
| Main Authors: | Maulana, Ahmad Fariz, Maksum, Iman Permana, Sriwidodo, Sriwidodo, Rukayadi, Yaya |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2024
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/118875/ http://psasir.upm.edu.my/id/eprint/118875/1/118875.pdf |
Similar Items
In silico study of mangostin compounds and its derivatives as inhibitors of α-glucosidase enzymes for anti-diabetic studies
by: Maulana, Ahmad Fariz, et al.
Published: (2022)
by: Maulana, Ahmad Fariz, et al.
Published: (2022)
Study of the antidiabetic mechanism of berberine compound on FOXO1 transcription factor through molecular docking and molecular dynamics simulations
by: Maksum, Iman Permana, et al.
Published: (2024)
by: Maksum, Iman Permana, et al.
Published: (2024)
Evaluating the Effect of Combined Plant Extracts on α-amylase and α-glucosidase Inhibition Activity as Antidiabetic Agents
by: Munem, Osama A., et al.
Published: (2020)
by: Munem, Osama A., et al.
Published: (2020)
Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl.
by: Loo, Kong Yong, et al.
Published: (2019)
by: Loo, Kong Yong, et al.
Published: (2019)
Stereospecific α-glucosidase inhibition, kinetics, and molecular docking studies on isolated diastereomeric alkaloids from Uncaria longiflora
by: Nurul Aina Suzlin, Sulaiman, et al.
Published: (2025)
by: Nurul Aina Suzlin, Sulaiman, et al.
Published: (2025)
Antioxidant activity, α-Glucosidase inhibition and UHPLC–ESI–MS/MS profile of Shmar (Arbutus pavarii Pamp)
by: Buzgaia, Nawal, et al.
Published: (2021)
by: Buzgaia, Nawal, et al.
Published: (2021)
Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin
by: Nazikussabah, Zaharudin, et al.
Published: (2019)
by: Nazikussabah, Zaharudin, et al.
Published: (2019)
α-Mangostin improves glucose uptake and inhibits adipocytes differentiation in 3T3-L1 cells
by: Mohamed Amiroudine, Mohamed Zaffar Ali, et al.
Published: (2014)
by: Mohamed Amiroudine, Mohamed Zaffar Ali, et al.
Published: (2014)
Synthesis And Molecular Docking Studies Of New Phenylisoxazole Quinoxaline-2-Amine Hybrids As Potential Α Amylase And Α-Glucosidase Inhibitors
by: Radzuan, Siti Nurshahira Mohd
Published: (2024)
by: Radzuan, Siti Nurshahira Mohd
Published: (2024)
Potential inhibitors of α-glucosidase and α-amylase enzymes from local
fruit waste by solid state fermentation
by: Ahmad Barkat, Anumsima, et al.
Published: (2016)
by: Ahmad Barkat, Anumsima, et al.
Published: (2016)
Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms
by: Syed Ibrahim, Nurul Huda, et al.
Published: (2014)
by: Syed Ibrahim, Nurul Huda, et al.
Published: (2014)
Development of chitosan-α-mangostin loaded nanoparticles as an anticancer agent
by: Elsaid Ali, Aimen Abdo, et al.
Published: (2011)
by: Elsaid Ali, Aimen Abdo, et al.
Published: (2011)
Mechanisms of α-mangostin-induced antinociception in a rodent model
by: Mohd. Sani, Mohd. Hijaz, et al.
Published: (2015)
by: Mohd. Sani, Mohd. Hijaz, et al.
Published: (2015)
In vitro α-amylase and α-glucosidase inhibitory activities of selected Malaysian plants and in vivo antidiabetic properties of enema glauca / Mohamad Jemain Mohamad Ridhwan
by: Mohamad Ridhwan, Mohamad Jemain
Published: (2011)
by: Mohamad Ridhwan, Mohamad Jemain
Published: (2011)
Potential inhibitors of α-glucosidase and α-amylase enzymes from locally available fruit wastes by solid state fermentation
by: Ahmad Barkat, Anumsima, et al.
Published: (2019)
by: Ahmad Barkat, Anumsima, et al.
Published: (2019)
Metabolomics combined with chemometric analysis to identify α-glucosidase inhibitors in Phaleria macrocarpa fruit extracts and its molecular docking simulation
by: Easmin, Sabina, et al.
Published: (2024)
by: Easmin, Sabina, et al.
Published: (2024)
Synthesis and characterisation of rice husk ash silica drug carrier for α-mangostin
by: Iqbal, Anwar, et al.
Published: (2018)
by: Iqbal, Anwar, et al.
Published: (2018)
Cloning and Expression of a Thermostable-α Glucosidase
by: A. Mohamed, Rauda
Published: (2010)
by: A. Mohamed, Rauda
Published: (2010)
α-glucosidase and 15-lipoxygenase inhibitory activities of
phytochemicals from calophyllum symingtonianum
by: Aminudin, Nurul Iman, et al.
Published: (2015)
by: Aminudin, Nurul Iman, et al.
Published: (2015)
Alpha-mangostin and beta-mangostin from Cratoxylum laucum.
by: Ee, Gwendoline Cheng Lian, et al.
Published: (2011)
by: Ee, Gwendoline Cheng Lian, et al.
Published: (2011)
α-mangostin improves glucose uptake and inhibits adipocytes differentiation in 3T3-L1 cells via PPARgamma, GLUT4, and leptin expressions
by: Taher, Muhammad, et al.
Published: (2015)
by: Taher, Muhammad, et al.
Published: (2015)
In vitro alpha-glucosidase and alpha-amylase enzyme-inhibited activities by water-lily (Nymphaea genus) extracts
by: Korawinwich Boonpisuttinant,, et al.
Published: (2019)
by: Korawinwich Boonpisuttinant,, et al.
Published: (2019)
Antihypertensive, antidiabetic, and antioxidant properties of novel Azolla pinnata fern protein hydrolysates: inhibition mechanism, stability, profiling, and molecular docking
by: Qoms, Mohammed S., et al.
Published: (2024)
by: Qoms, Mohammed S., et al.
Published: (2024)
α-Glucosidase inhibitory activity of selected Malaysian plants
by: Mohd Bukhari, Dzatil Awanis, et al.
Published: (2017)
by: Mohd Bukhari, Dzatil Awanis, et al.
Published: (2017)
Synthesis of cinnamamide derivatives and their α-glucosidase inhibitory activities
by: Teni Ernawati,, et al.
Published: (2020)
by: Teni Ernawati,, et al.
Published: (2020)
Synthesis of diarylpentadienones and pyrazoline derivatives as potential α-glucosidase inhibitor and their antioxidant activities
by: Adam, Faruk Auwal, et al.
Published: (2023)
by: Adam, Faruk Auwal, et al.
Published: (2023)
Characterization of α-glucosidase inhibitors from clinacanthus nutans lindau Llaves by gas chromatography-mass spectrometry-based metabolomics and molecular docking simulation
by: Murugesu, Suganya, et al.
Published: (2018)
by: Murugesu, Suganya, et al.
Published: (2018)
Flavonoids from Clerodendrum genus and their biological activities
by: Mamuaja, Meiske Naomi, et al.
Published: (2024)
by: Mamuaja, Meiske Naomi, et al.
Published: (2024)
Synthesis, structural characterisation and theoretical studies of a novel pyridazine derivative: Investigations of anti-inflammatory activity and inhibition of α-glucosidase
by: Zaoui, Younes, et al.
Published: (2021)
by: Zaoui, Younes, et al.
Published: (2021)
α-glucosidase inhibitors isolated from Mimosa pudica L.
by: Tasnuva, S. T., et al.
Published: (2017)
by: Tasnuva, S. T., et al.
Published: (2017)
Apoptotic effects of α-Mangostin on cervical cancer cell line / Aisha I. I. El Habbash
by: Aisha I. I., El Habbash
Published: (2018)
by: Aisha I. I., El Habbash
Published: (2018)
Identification of α-glucosidase inhibitorsfrom Clinacanthus nutans leaf extract using liquid chromatography-mass spectrometry-based metabolomics and protein-ligand interaction with molecular docking
by: Murugesu, Suganya, et al.
Published: (2019)
by: Murugesu, Suganya, et al.
Published: (2019)
The in vitro a-glucosidase inhibition activity of various solvent fractions of Tamarix dioica and 1H-NMR based metabolite identification and molecular docking analysis
by: Niaz, Aamir, et al.
Published: (2021)
by: Niaz, Aamir, et al.
Published: (2021)
In vitro antidiabetic effects of flavonoids: molecular and structure-activity relationship based study
by: Sarian, Murni Nazira, et al.
Published: (2018)
by: Sarian, Murni Nazira, et al.
Published: (2018)
Mangostins stimulate glucose uptake and inhibit adipocyte differentiation in 3T3-L1 adipocytes
by: Bakhtiar, M. Taher, et al.
Published: (2012)
by: Bakhtiar, M. Taher, et al.
Published: (2012)
Identification of α-glucosidase inhibitory compounds from Curcuma mangga fractions
by: Awin, Tahani M., et al.
Published: (2020)
by: Awin, Tahani M., et al.
Published: (2020)
Identification of α-glucosidase inhibitors from Clinacanthus nutans leaf extract using liquid chromatography-mass spectrometry-based metabolomics and protein-ligand interaction with molecular docking
by: Murugesu, Suganya, et al.
Published: (2019)
by: Murugesu, Suganya, et al.
Published: (2019)
Antiobesity effects of α-mangostin through glut4 and leptin expression together with pparγ activation in adipocytes
by: Bakhtiar, M. Taher, et al.
Published: (2013)
by: Bakhtiar, M. Taher, et al.
Published: (2013)
α-Mangostin from cratoxylum arborescens (Vahl) blume demonstrates anti-ulcerogenic property : a mechanistic study
by: Sidahmed, Heyam M. A., et al.
Published: (2013)
by: Sidahmed, Heyam M. A., et al.
Published: (2013)
Curcumin, a bioactive compound of Turmeric (Curcuma longa) and its derivatives as α-amylase and α-glucosidase inhibitors
by: Roney, Miah, et al.
Published: (2024)
by: Roney, Miah, et al.
Published: (2024)
Similar Items
-
In silico study of mangostin compounds and its derivatives as inhibitors of α-glucosidase enzymes for anti-diabetic studies
by: Maulana, Ahmad Fariz, et al.
Published: (2022) -
Study of the antidiabetic mechanism of berberine compound on FOXO1 transcription factor through molecular docking and molecular dynamics simulations
by: Maksum, Iman Permana, et al.
Published: (2024) -
Evaluating the Effect of Combined Plant Extracts on α-amylase and α-glucosidase Inhibition Activity as Antidiabetic Agents
by: Munem, Osama A., et al.
Published: (2020) -
Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl.
by: Loo, Kong Yong, et al.
Published: (2019) -
Stereospecific α-glucosidase inhibition, kinetics, and molecular docking studies on isolated diastereomeric alkaloids from Uncaria longiflora
by: Nurul Aina Suzlin, Sulaiman, et al.
Published: (2025)