The restoration of REST inhibits reactivity of Down syndrome iPSC-derived astrocytes

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The restoration of REST inhibits reactivity of Down syndrome iPSC-derived astrocytes

IntroductionAccumulating evidence indicates that the increased presence of astrocytes is fundamentally linked to the neurological dysfunctions observed in individuals with Down syndrome (DS). REST (RE1-silencing transcription factor), as a chromatin modifier, regulates 15,450 genes in humans. REST i...

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Bibliographic Details
Main Authors:	Huang, Tan, Fakurazi, Sharida, Cheah, Pike See, Ling, King Hwa
Format:	Article
Language:	English
Published:	Frontiers Media SA 2025
Online Access:	http://psasir.upm.edu.my/id/eprint/118591/ http://psasir.upm.edu.my/id/eprint/118591/1/118591.pdf

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