Acute and subacute oral toxicity assessment of the polysaccharides extracted from Clinacanthus nutans leaves: a preclinical model for drug safety screening

QR Code

Acute and subacute oral toxicity assessment of the polysaccharides extracted from Clinacanthus nutans leaves: a preclinical model for drug safety screening

Emerging investigations have indicated that many plant polysaccharides may be beneficial for treating metabolic diseases. To date, the therapeutic efficacy and potential toxicity of polysaccharides extracted from Clinacanthus nutans (C. nutans) remain unexplored. This study investigated the in vivo...

Full description

Bibliographic Details
Main Authors:	Chia, Tan Yong, Gan, Chee Yuen, Kaur, Gurjeet, Cheah, Pike See, Murugaiyah, Vikneswaran, Ahmad, Ashfaq, Alsuwayt, Bader, Alnasser, Sulaiman Mohammed Abdullah, Shafie, Muhammad Hakimin, Nair, Selvamani Narayan, Abdulla, Mohammed H., Johns, Edward James
Format:	Article
Language:	English
Published:	Penerbit Universiti Sains Malaysia 2025
Online Access:	http://psasir.upm.edu.my/id/eprint/118499/ http://psasir.upm.edu.my/id/eprint/118499/1/118499.pdf

Similar Items

Renoprotective and antihypertensive mechanism of action of Clinacanthus nutans bioactive polysaccharides by suppression of reactive oxygen species/ nuclear factor/ matrix metalloproteinase (ROS/NF-ΚB/MMP-9) and upregulation of endothelial nitric oxide synthase/nitric oxide (eNOS/NO) pathways
by: Chia, Tan Yong, et al.
Published: (2025)

Clinacanthus nutans aqueous extract exerts anti-allergic activity in preclinical anaphylactic models via alternative IgG pathway
by: Kow, Audrey Siew Foong, et al.
Published: (2023)

Infrared drying of Clinacanthus nutans leaves
by: Abdullah, Sriyana, et al.
Published: (2022)

Green Synthesis Of Silver Nanoparticles From Water-Soluble Polysaccharides Of Clinacanthus Nutans Leaf: Extraction, Characterisation, Optimisation And Antibacterial Studies
by: Devasvaran, Kogilavanee
Published: (2023)

Clinacanthus nutans crude polysaccharide extract as a green platform for microwave-assisted synthesis of silver nanoparticles: optimization, characterization, and evaluation of bioactivities
by: Devasvaran, Kogilavanee, et al.
Published: (2024)

Clinacanthus nutans crude polysaccharide extract as a green platform for microwave-assisted synthesis of silver nanoparticles: Optimization, characterization, and evaluation of bioactivities
by: Devasvaran, Kogilavanee, et al.
Published: (2024)

A review on anticancer and biochemical properties of Clinacanthus nutans
by: Zakaria, Khairun Najwa, et al.
Published: (2016)

A review of anticancer, antitumor, and antioxidant of clinacanthus nutans
by: Zakaria, Khairun Najwa, et al.
Published: (2017)

Ultrasonic extraction of Clinacanthus nutans and its antioxidant activity
by: Nik Fatima, Nek Kamarzaman
Published: (2013)

Assessing potential for heavy metal phytoremediation in Clinacanthus nutans
by: Mohd Sapri, Nurul Aisyah
Published: (2018)

Immunomodulatory and cell cycle regulatory effects of clinacanthus nutans
by: Ghazali, Wan Afiqah Syahirah Wan @ Wan Azmi
Published: (2018)

Clinacanthus nutans: a review of the medicinal uses, pharmacology and phytochemistry
by: Alam, Md Ariful, et al.
Published: (2016)

Investigation of immunomodulatory effects of phytosterols isolated from Clinacanthus nutans
by: Liew, Crystal Xiao-Qi
Published: (2025)

Belalai gajah (clinacanthus nutans) scientific evidence of cancer prevention
by: Hazrulrizawati, Hamid, et al.
Published: (2020)

Isolation and characterization of apoptosis-inducing compounds from Clinacanthus nutans
by: Hazrulrizawati, Abd Hamid
Published: (2014)

Chemical constituents from the butanol fraction of Clinacanthus nutans leaves
by: Zolkeflee, Nur Khaleeda Zulaikha, et al.
Published: (2022)

Fabrication of face cream containing enriched fraction of protocatechuic acid from Clinacanthus nutans (C. Nutans) leaves
by: Zamery, Muhammad 'Izzuddin, et al.
Published: (2017)

Pharmacological activities and comprehensive metabolite profiling of Clinacanthus nutans extract and fractions
by: Alam, Md. Ariful, et al.
Published: (2016)

Extraction of protocatechuic acid enriched fraction from Clinacanthus nutans leaves
by: Zamery, Muhammad 'Izzuddin, et al.
Published: (2017)

The Effects of Clinacanthus nutans Leaf Extract Towards Tyrosinase and Collagenase Activities
by: Lim, She Yan
Published: (2017)

A review of therapeutic potentials of Clinacanthus nutans as source for alternative medicines
by: Zainol Haida,, et al.
Published: (2019)

Biogenic silver nanoparticles of Clinacanthus nutans as antioxidant with antimicrobial and cytotoxic effects
by: Hock, Ing Chiu, et al.
Published: (2021)

Cytotoxic, mutagenic and oral pathogen related antimicrobial properties of clinacanthus nutans
by: Alim, A'attiyyah Ab
Published: (2018)

Pharmacological effects of Clinacanthus nutans Lindau and its potential cosmeceutical values: a comprehensive review
by: Zamery, Muhammad ‘Izzuddin, et al.
Published: (2020)

Antidiabetic and antioxidants activities of Clinacanthus nutans (Burm F.) Lindau leaves extracts
by: Murugesu, Suganya, et al.
Published: (2019)

Antidiabetic and antioxidants activities of Clinacanthus nutans(Burm F.) Lindau leaves extracts
by: S., Murugesu, et al.
Published: (2019)

Antidiabetic and antioxidants activities of Clinacanthus nutans (Burm F.) Lindau leaves extracts
by: Murugesu, Suganya, et al.
Published: (2019)

Cytotoxicity Of Clinacanthus Nutans Methanol-Water Extract On Huh-7 Cell Line
by: Chuah, Jia Jun
Published: (2017)

Protein expression patterns in HEK-blue-cells treated with Clinacanthus nutans extracts
by: Yang, Shun Kai, et al.
Published: (2020)

The effect of different 6-benzylaminopurine (BAP) concentrations on axillary branching of Clinacanthus nutans
by: Mohamad, Fatin Haziqah
Published: (2016)

The effect of different kinetin concentration on shoot multiplication of Clinacanthus nutans node culture
by: Zakaria, Nur Syazwani
Published: (2018)

Transcriptome Analysis Of Cervical Cancer Cells (Hela) Treated With Clinacanthus Nutans Extract
by: Haron, Nor Hasyimah
Published: (2021)

Genetic And Chemical Variation Of Clinacanthus Nutans From Northern Region Of Peninsular Malaysia
by: Ismail, Noor Zafirah
Published: (2018)

Establishment Of In Vitro Culture Techniques For Clinacanthus Nutans And The Evaluation On Its Antioxidant Potential
by: Bong, Fui Joo
Published: (2021)

Phytochemical diversity of Clinacanthus nutans extracts and their bioactivity correlations elucidated by NMR based metabolomics
by: Leng, Wei Khoo, et al.
Published: (2015)

Toxicity study on Clinacanthus nutans leaf hexane fraction using Danio rerio embryos
by: Murugesu, Suganya, et al.
Published: (2019)

Discrimination of clinacanthus nutans extracts and correlation with antiplasmodial activity using ATR-FTIR fingerprinting
by: Noor Hashim, Noor, et al.
Published: (2019)

Cytotoxicity of Clinacanthus Nutans Extracts on Human Hepatoma (HepG2) Cell Line
by: Hazrulrizawati, Hamid, et al.
Published: (2016)

Bioassay-guided Isolation and Antioxidant Activity of Sulfur-containing Compounds from Clinacanthus nutans
by: Hazrulrizawati, Hamid, et al.
Published: (2016)

Plant vegetative stages and drying methods affect flavonoid content of Clinacanthus nutans extracts
by: Mohamad, Munirah, et al.
Published: (2018)