The metabolic syndrome: an overview and proposed mechanisms
Obesity has emerged as a major public health challenge in the 21st century, contributing to the rising prevalence of metabolic syndrome (MetS), a cluster of interrelated health risk factors. These factors include obesity or abdominal obesity, type 2 diabetes mellitus (T2DM), hypertension (HTN), and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Multidisciplinary Digital Publishing Institute
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/118284/ http://psasir.upm.edu.my/id/eprint/118284/1/118284.pdf |
| _version_ | 1848867478671720448 |
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| author | Thomaz, Fernanda Santos John, Oliver Dean Sinha, Payel Shafie, Siti Raihanah Worrall, Simon |
| author_facet | Thomaz, Fernanda Santos John, Oliver Dean Sinha, Payel Shafie, Siti Raihanah Worrall, Simon |
| author_sort | Thomaz, Fernanda Santos |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Obesity has emerged as a major public health challenge in the 21st century, contributing to the rising prevalence of metabolic syndrome (MetS), a cluster of interrelated health risk factors. These factors include obesity or abdominal obesity, type 2 diabetes mellitus (T2DM), hypertension (HTN), and dyslipidaemia. In this review, we will explore important aspects of metabolic regulation and the dynamics of lipoprotein metabolism to see how they underlie each of these major health risks. Additionally, we will highlight the role of ferroptosis, an iron-dependent regulated cell death process, in relation to inflammatory responses and its critical contribution to the pathophysiology of MetS. These inflammatory responses include inflammasome activation, lipotoxicity, the influence of adipocytokines, and the role of adipose tissue macrophages. By exploring these interconnections, this review aims to provide insights into metabolic crosstalk, outline the pathological mechanisms occurring, and identify potential therapeutic targets for managing and preventing the progression of these health risk factors. |
| first_indexed | 2025-11-15T14:37:08Z |
| format | Article |
| id | upm-118284 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:37:08Z |
| publishDate | 2024 |
| publisher | Multidisciplinary Digital Publishing Institute |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1182842025-07-03T07:59:36Z http://psasir.upm.edu.my/id/eprint/118284/ The metabolic syndrome: an overview and proposed mechanisms Thomaz, Fernanda Santos John, Oliver Dean Sinha, Payel Shafie, Siti Raihanah Worrall, Simon Obesity has emerged as a major public health challenge in the 21st century, contributing to the rising prevalence of metabolic syndrome (MetS), a cluster of interrelated health risk factors. These factors include obesity or abdominal obesity, type 2 diabetes mellitus (T2DM), hypertension (HTN), and dyslipidaemia. In this review, we will explore important aspects of metabolic regulation and the dynamics of lipoprotein metabolism to see how they underlie each of these major health risks. Additionally, we will highlight the role of ferroptosis, an iron-dependent regulated cell death process, in relation to inflammatory responses and its critical contribution to the pathophysiology of MetS. These inflammatory responses include inflammasome activation, lipotoxicity, the influence of adipocytokines, and the role of adipose tissue macrophages. By exploring these interconnections, this review aims to provide insights into metabolic crosstalk, outline the pathological mechanisms occurring, and identify potential therapeutic targets for managing and preventing the progression of these health risk factors. Multidisciplinary Digital Publishing Institute 2024-07-22 Article PeerReviewed text en cc_by_4 http://psasir.upm.edu.my/id/eprint/118284/1/118284.pdf Thomaz, Fernanda Santos and John, Oliver Dean and Sinha, Payel and Shafie, Siti Raihanah and Worrall, Simon (2024) The metabolic syndrome: an overview and proposed mechanisms. Obesities, 4 (3). pp. 226-255. ISSN 2673-4168; eISSN: 2673-4168 https://www.mdpi.com/2673-4168/4/3/20 10.3390/obesities4030020 |
| spellingShingle | Thomaz, Fernanda Santos John, Oliver Dean Sinha, Payel Shafie, Siti Raihanah Worrall, Simon The metabolic syndrome: an overview and proposed mechanisms |
| title | The metabolic syndrome: an overview and proposed mechanisms |
| title_full | The metabolic syndrome: an overview and proposed mechanisms |
| title_fullStr | The metabolic syndrome: an overview and proposed mechanisms |
| title_full_unstemmed | The metabolic syndrome: an overview and proposed mechanisms |
| title_short | The metabolic syndrome: an overview and proposed mechanisms |
| title_sort | metabolic syndrome: an overview and proposed mechanisms |
| url | http://psasir.upm.edu.my/id/eprint/118284/ http://psasir.upm.edu.my/id/eprint/118284/ http://psasir.upm.edu.my/id/eprint/118284/ http://psasir.upm.edu.my/id/eprint/118284/1/118284.pdf |