Co-occurrence of autoimmune haemolytic anaemia and β-thalassaemia major in an infant: a case report and updated pathogenic insight
Thalassaemia, a common inherited blood disorder, involves defective globin production leading to premature erythrocyte destruction. Autoimmune haemolytic anaemia (AIHA), a rare complication in thalassaemia, is characterised by autoantibody production against erythrocytes. We present a case of a 7-mo...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, UPM
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/118152/ http://psasir.upm.edu.my/id/eprint/118152/1/118152.pdf |
| _version_ | 1848867445381529600 |
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| author | Idris, Faridah Abd Rahman, Siti Umairah Mohd Tohit, Eusni Rahayu Stephen, Claudia Cassandra Mohamed, Rashidah Wan Alkamar Shah, Wan Nurul Husna |
| author_facet | Idris, Faridah Abd Rahman, Siti Umairah Mohd Tohit, Eusni Rahayu Stephen, Claudia Cassandra Mohamed, Rashidah Wan Alkamar Shah, Wan Nurul Husna |
| author_sort | Idris, Faridah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Thalassaemia, a common inherited blood disorder, involves defective globin production leading to premature erythrocyte destruction. Autoimmune haemolytic anaemia (AIHA), a rare complication in thalassaemia, is characterised by autoantibody production against erythrocytes. We present a case of a 7-month-old boy diagnosed with β-thalassaemia major (BTM), complicated by AIHA six weeks after initiating blood transfusions. Despite daily transfusions and oral Prednisolone, the haemoglobin (Hb) level dropped to a life-threatening level (2.5g/dl). High-dose IV Methylprednisolone and Rituximab were administered, resulting in Hb improvement to 11.9 g/dL. AIHA resolution was indicated by negative C3d and reduced IgG on repeated testing. Recognition of AIHA in BTM is vital for effective management, including immunosuppressive therapy, leucodepleted transfusions, and potential splenectomy or haematopoietic stem cell transplant. Early intervention is crucial to reduce the mortality associated with AIHA in children. |
| first_indexed | 2025-11-15T14:36:37Z |
| format | Article |
| id | upm-118152 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:36:37Z |
| publishDate | 2024 |
| publisher | Faculty of Medicine and Health Sciences, UPM |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1181522025-06-26T02:21:53Z http://psasir.upm.edu.my/id/eprint/118152/ Co-occurrence of autoimmune haemolytic anaemia and β-thalassaemia major in an infant: a case report and updated pathogenic insight Idris, Faridah Abd Rahman, Siti Umairah Mohd Tohit, Eusni Rahayu Stephen, Claudia Cassandra Mohamed, Rashidah Wan Alkamar Shah, Wan Nurul Husna Thalassaemia, a common inherited blood disorder, involves defective globin production leading to premature erythrocyte destruction. Autoimmune haemolytic anaemia (AIHA), a rare complication in thalassaemia, is characterised by autoantibody production against erythrocytes. We present a case of a 7-month-old boy diagnosed with β-thalassaemia major (BTM), complicated by AIHA six weeks after initiating blood transfusions. Despite daily transfusions and oral Prednisolone, the haemoglobin (Hb) level dropped to a life-threatening level (2.5g/dl). High-dose IV Methylprednisolone and Rituximab were administered, resulting in Hb improvement to 11.9 g/dL. AIHA resolution was indicated by negative C3d and reduced IgG on repeated testing. Recognition of AIHA in BTM is vital for effective management, including immunosuppressive therapy, leucodepleted transfusions, and potential splenectomy or haematopoietic stem cell transplant. Early intervention is crucial to reduce the mortality associated with AIHA in children. Faculty of Medicine and Health Sciences, UPM 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/118152/1/118152.pdf Idris, Faridah and Abd Rahman, Siti Umairah and Mohd Tohit, Eusni Rahayu and Stephen, Claudia Cassandra and Mohamed, Rashidah and Wan Alkamar Shah, Wan Nurul Husna (2024) Co-occurrence of autoimmune haemolytic anaemia and β-thalassaemia major in an infant: a case report and updated pathogenic insight. Malaysian Journal of Medicine and Health Sciences, 20 (suppl.11). pp. 88-91. ISSN 1675-8544 https://medic.upm.edu.my/upload/dokumen/2024123018293516_MJMHS_0412.pdf 10.47836/mjmhs.20.s11.16 |
| spellingShingle | Idris, Faridah Abd Rahman, Siti Umairah Mohd Tohit, Eusni Rahayu Stephen, Claudia Cassandra Mohamed, Rashidah Wan Alkamar Shah, Wan Nurul Husna Co-occurrence of autoimmune haemolytic anaemia and β-thalassaemia major in an infant: a case report and updated pathogenic insight |
| title | Co-occurrence of autoimmune haemolytic anaemia and β-thalassaemia major in an infant: a case report and updated pathogenic insight |
| title_full | Co-occurrence of autoimmune haemolytic anaemia and β-thalassaemia major in an infant: a case report and updated pathogenic insight |
| title_fullStr | Co-occurrence of autoimmune haemolytic anaemia and β-thalassaemia major in an infant: a case report and updated pathogenic insight |
| title_full_unstemmed | Co-occurrence of autoimmune haemolytic anaemia and β-thalassaemia major in an infant: a case report and updated pathogenic insight |
| title_short | Co-occurrence of autoimmune haemolytic anaemia and β-thalassaemia major in an infant: a case report and updated pathogenic insight |
| title_sort | co-occurrence of autoimmune haemolytic anaemia and β-thalassaemia major in an infant: a case report and updated pathogenic insight |
| url | http://psasir.upm.edu.my/id/eprint/118152/ http://psasir.upm.edu.my/id/eprint/118152/ http://psasir.upm.edu.my/id/eprint/118152/ http://psasir.upm.edu.my/id/eprint/118152/1/118152.pdf |