Antioxidant activity of Zingiber cassumunar rhizome, Guazuma ulmifolia leaves and their combination in high-fat diet-fed rats
Oxidative stress is related to several metabolic diseases, including hyperlipidemia. Previous studies have shown the antioxidant properties of Zingiber cassumunar rhizomes and Guazuma ulmifolia leaves. The objective of this study was to see the antioxidant activity of Z. cassumunar rhizomes, G. ulmi...
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| Format: | Article |
| Language: | English |
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Universitas Gadjah Mada
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/118145/ http://psasir.upm.edu.my/id/eprint/118145/1/118145.pdf |
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| author | Othman, Fezah Nurkhasanah Mahfudh, . Nanik Sulistyani, . Ika Dyah Kumalasari, . Randa Sandira Reski, . Rizal Mahendra, . Rista Eka Nabila, . Zakaria, Zainul Amiruddin |
| author_facet | Othman, Fezah Nurkhasanah Mahfudh, . Nanik Sulistyani, . Ika Dyah Kumalasari, . Randa Sandira Reski, . Rizal Mahendra, . Rista Eka Nabila, . Zakaria, Zainul Amiruddin |
| author_sort | Othman, Fezah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Oxidative stress is related to several metabolic diseases, including hyperlipidemia. Previous studies have shown the antioxidant properties of Zingiber cassumunar rhizomes and Guazuma ulmifolia leaves. The objective of this study was to see the antioxidant activity of Z. cassumunar rhizomes, G. ulmifolia leaves extracts, and their combinations in high-fat diet fed (HFD) rat. The water extract of Z. cassumunar rhizomes and G. ulmifolia leaves was evaporated in a freeze dryer to produce dry extracts. The Wistar rats were assigned into six groups at random: normal, positive, negative, Z. cassumunar rhizome extract at 400 mg/kg BW (ZC); G. ulmifolia leaf extract at 50 mg/kg BW (GU), and the combination of Z. cassumunar rhizome extract and G. ulmifolia leaf extract at (350+50) mg/kg BW (ZC+GU). The rats were fed HFD for 28 days, and the treatment groups also received the extracts for the last 14 days. The combination ZC+GU increased the endogenous antioxidant activity namely superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px). The metabolite oxidation, malondialdehyde (MDA) was also found to decrease. The conclusion of the study showed that ZC, GU, and ZC+GU had quite high antioxidant activity to inhibiting oxidative stress. |
| first_indexed | 2025-11-15T14:36:35Z |
| format | Article |
| id | upm-118145 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:36:35Z |
| publishDate | 2024 |
| publisher | Universitas Gadjah Mada |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1181452025-06-26T00:32:28Z http://psasir.upm.edu.my/id/eprint/118145/ Antioxidant activity of Zingiber cassumunar rhizome, Guazuma ulmifolia leaves and their combination in high-fat diet-fed rats Othman, Fezah Nurkhasanah Mahfudh, . Nanik Sulistyani, . Ika Dyah Kumalasari, . Randa Sandira Reski, . Rizal Mahendra, . Rista Eka Nabila, . Zakaria, Zainul Amiruddin Oxidative stress is related to several metabolic diseases, including hyperlipidemia. Previous studies have shown the antioxidant properties of Zingiber cassumunar rhizomes and Guazuma ulmifolia leaves. The objective of this study was to see the antioxidant activity of Z. cassumunar rhizomes, G. ulmifolia leaves extracts, and their combinations in high-fat diet fed (HFD) rat. The water extract of Z. cassumunar rhizomes and G. ulmifolia leaves was evaporated in a freeze dryer to produce dry extracts. The Wistar rats were assigned into six groups at random: normal, positive, negative, Z. cassumunar rhizome extract at 400 mg/kg BW (ZC); G. ulmifolia leaf extract at 50 mg/kg BW (GU), and the combination of Z. cassumunar rhizome extract and G. ulmifolia leaf extract at (350+50) mg/kg BW (ZC+GU). The rats were fed HFD for 28 days, and the treatment groups also received the extracts for the last 14 days. The combination ZC+GU increased the endogenous antioxidant activity namely superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px). The metabolite oxidation, malondialdehyde (MDA) was also found to decrease. The conclusion of the study showed that ZC, GU, and ZC+GU had quite high antioxidant activity to inhibiting oxidative stress. Universitas Gadjah Mada 2024-12-17 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/118145/1/118145.pdf Othman, Fezah and Nurkhasanah Mahfudh, . and Nanik Sulistyani, . and Ika Dyah Kumalasari, . and Randa Sandira Reski, . and Rizal Mahendra, . and Rista Eka Nabila, . and Zakaria, Zainul Amiruddin (2024) Antioxidant activity of Zingiber cassumunar rhizome, Guazuma ulmifolia leaves and their combination in high-fat diet-fed rats. Indonesian Journal of Pharmacy, 35 (4). pp. 660-668. ISSN 2338-9427; eISSN: 2338-9486 https://jurnal.ugm.ac.id/v3/IJP/article/view/8220 10.22146/ijp.8220 |
| spellingShingle | Othman, Fezah Nurkhasanah Mahfudh, . Nanik Sulistyani, . Ika Dyah Kumalasari, . Randa Sandira Reski, . Rizal Mahendra, . Rista Eka Nabila, . Zakaria, Zainul Amiruddin Antioxidant activity of Zingiber cassumunar rhizome, Guazuma ulmifolia leaves and their combination in high-fat diet-fed rats |
| title | Antioxidant activity of Zingiber cassumunar rhizome, Guazuma ulmifolia leaves and their combination in high-fat diet-fed rats |
| title_full | Antioxidant activity of Zingiber cassumunar rhizome, Guazuma ulmifolia leaves and their combination in high-fat diet-fed rats |
| title_fullStr | Antioxidant activity of Zingiber cassumunar rhizome, Guazuma ulmifolia leaves and their combination in high-fat diet-fed rats |
| title_full_unstemmed | Antioxidant activity of Zingiber cassumunar rhizome, Guazuma ulmifolia leaves and their combination in high-fat diet-fed rats |
| title_short | Antioxidant activity of Zingiber cassumunar rhizome, Guazuma ulmifolia leaves and their combination in high-fat diet-fed rats |
| title_sort | antioxidant activity of zingiber cassumunar rhizome, guazuma ulmifolia leaves and their combination in high-fat diet-fed rats |
| url | http://psasir.upm.edu.my/id/eprint/118145/ http://psasir.upm.edu.my/id/eprint/118145/ http://psasir.upm.edu.my/id/eprint/118145/ http://psasir.upm.edu.my/id/eprint/118145/1/118145.pdf |