Thymoma-associated good syndrome: a case report and literature review
Thymoma is often associated with many other autoimmune disorders and clinical conditions. Good syndrome is one of the rare associations between thymoma and immune deficiency that occurs in both males and females in the 4th or 5th decade of life. Patients can present with various invasive encapsulate...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
European Medical Group
2024
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/118136/ http://psasir.upm.edu.my/id/eprint/118136/1/118136.pdf |
| _version_ | 1848867441103339520 |
|---|---|
| author | Muhd Yazid, Nurafiqah Farhana Chung, Ho Wen Ahmad Senusi, Nur Qystina |
| author_facet | Muhd Yazid, Nurafiqah Farhana Chung, Ho Wen Ahmad Senusi, Nur Qystina |
| author_sort | Muhd Yazid, Nurafiqah Farhana |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Thymoma is often associated with many other autoimmune disorders and clinical conditions. Good syndrome is one of the rare associations between thymoma and immune deficiency that occurs in both males and females in the 4th or 5th decade of life. Patients can present with various invasive encapsulated organisms, and opportunistic viral and fungal infections, due to immune defects. The authors report a case of a 57-year-old male with underlying thymoma and lichen planus which were diagnosed 3 years apart. He presented with atypical pneumonia during the COVID-19 pandemic, and was treated for multiple atypical infections, including cytomegalovirus and Pneumocystis carinii pneumonia. His immunological investigation panel revealed low IgA and IgG levels with normal IgM levels, and an overall deficient total B cell count. His CD4:CD8 ratio was reversed at 0.28. The patient recovered well after Ig replacement therapy once the Good syndrome diagnosis was made. The authors highlight the importance of a high index of clinical suspicion in dealing with this uncommon concomitant occurrence of Good syndrome during the COVID-19 pandemic for a swift and timely diagnosis and management. Immunological investigation panels, including T cell subsets, B cells, and quantitative Ig levels, should be considered routinely in patients with underlying thymoma presenting with opportunistic infections. |
| first_indexed | 2025-11-15T14:36:32Z |
| format | Article |
| id | upm-118136 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:36:32Z |
| publishDate | 2024 |
| publisher | European Medical Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1181362025-06-25T07:25:19Z http://psasir.upm.edu.my/id/eprint/118136/ Thymoma-associated good syndrome: a case report and literature review Muhd Yazid, Nurafiqah Farhana Chung, Ho Wen Ahmad Senusi, Nur Qystina Thymoma is often associated with many other autoimmune disorders and clinical conditions. Good syndrome is one of the rare associations between thymoma and immune deficiency that occurs in both males and females in the 4th or 5th decade of life. Patients can present with various invasive encapsulated organisms, and opportunistic viral and fungal infections, due to immune defects. The authors report a case of a 57-year-old male with underlying thymoma and lichen planus which were diagnosed 3 years apart. He presented with atypical pneumonia during the COVID-19 pandemic, and was treated for multiple atypical infections, including cytomegalovirus and Pneumocystis carinii pneumonia. His immunological investigation panel revealed low IgA and IgG levels with normal IgM levels, and an overall deficient total B cell count. His CD4:CD8 ratio was reversed at 0.28. The patient recovered well after Ig replacement therapy once the Good syndrome diagnosis was made. The authors highlight the importance of a high index of clinical suspicion in dealing with this uncommon concomitant occurrence of Good syndrome during the COVID-19 pandemic for a swift and timely diagnosis and management. Immunological investigation panels, including T cell subsets, B cells, and quantitative Ig levels, should be considered routinely in patients with underlying thymoma presenting with opportunistic infections. European Medical Group 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/118136/1/118136.pdf Muhd Yazid, Nurafiqah Farhana and Chung, Ho Wen and Ahmad Senusi, Nur Qystina (2024) Thymoma-associated good syndrome: a case report and literature review. EMJ Allergy & Immunology, 9 (1). pp. 70-75. ISSN 2398-9130 https://www.emjreviews.com/allergy-immunology/article/thymoma-associated-good-syndrome-a-case-report-and-literature-review/ 10.33590/emjallergyimmunol/smlf2152 |
| spellingShingle | Muhd Yazid, Nurafiqah Farhana Chung, Ho Wen Ahmad Senusi, Nur Qystina Thymoma-associated good syndrome: a case report and literature review |
| title | Thymoma-associated good syndrome: a case report and literature review |
| title_full | Thymoma-associated good syndrome: a case report and literature review |
| title_fullStr | Thymoma-associated good syndrome: a case report and literature review |
| title_full_unstemmed | Thymoma-associated good syndrome: a case report and literature review |
| title_short | Thymoma-associated good syndrome: a case report and literature review |
| title_sort | thymoma-associated good syndrome: a case report and literature review |
| url | http://psasir.upm.edu.my/id/eprint/118136/ http://psasir.upm.edu.my/id/eprint/118136/ http://psasir.upm.edu.my/id/eprint/118136/ http://psasir.upm.edu.my/id/eprint/118136/1/118136.pdf |