A case report of myelodysplastic and myeloproliferative neoplasms (MDS/MPN) with neutrophilia; an evidence of changes in their dynamics
Myelodysplastic and myeloproliferative neoplasms (MDS/MPN) with neutrophilia, previously referred to as atypical chronic myeloid leukaemia (aCML), constitute a disease entity of BCR-ABL1 negative MDS/MPN according to the new 5th edition World Health Organization (WHO) classification. It is character...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Malaysian Journal of Medicine and Health Sciences, UPM
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/117924/ http://psasir.upm.edu.my/id/eprint/117924/1/117924.pdf |
| _version_ | 1848867381759180800 |
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| author | Mohd Tohit, Eusni Rahayu Nazar Shah, Norhanis Khalid, Bahariah Md Noor, Sabariah |
| author_facet | Mohd Tohit, Eusni Rahayu Nazar Shah, Norhanis Khalid, Bahariah Md Noor, Sabariah |
| author_sort | Mohd Tohit, Eusni Rahayu |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Myelodysplastic and myeloproliferative neoplasms (MDS/MPN) with neutrophilia, previously referred to as atypical chronic myeloid leukaemia (aCML), constitute a disease entity of BCR-ABL1 negative MDS/MPN according to the new 5th edition World Health Organization (WHO) classification. It is characterized by an overlap syndrome that combines features of both myelodysplastic and myeloproliferative disorders, with a high propensity for progressing to acute myeloid leukaemia (AML) and an overall unfavourable prognosis. We report the case of a 72-year-old female who was referred to our hospital for further investigation of anaemia, thrombocytopaenia, and leucocytosis and was diagnosed with MDS/MPN with neutrophilia. Bone marrow morphology exhibited hypercellular marrow with dysplastic features in all three lineages. Our case report and literature review offer valuable insights into the dynamics of the morphological features of MDS/MPN with neutrophilia. |
| first_indexed | 2025-11-15T14:35:36Z |
| format | Article |
| id | upm-117924 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:35:36Z |
| publishDate | 2024 |
| publisher | Malaysian Journal of Medicine and Health Sciences, UPM |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1179242025-06-17T02:42:52Z http://psasir.upm.edu.my/id/eprint/117924/ A case report of myelodysplastic and myeloproliferative neoplasms (MDS/MPN) with neutrophilia; an evidence of changes in their dynamics Mohd Tohit, Eusni Rahayu Nazar Shah, Norhanis Khalid, Bahariah Md Noor, Sabariah Myelodysplastic and myeloproliferative neoplasms (MDS/MPN) with neutrophilia, previously referred to as atypical chronic myeloid leukaemia (aCML), constitute a disease entity of BCR-ABL1 negative MDS/MPN according to the new 5th edition World Health Organization (WHO) classification. It is characterized by an overlap syndrome that combines features of both myelodysplastic and myeloproliferative disorders, with a high propensity for progressing to acute myeloid leukaemia (AML) and an overall unfavourable prognosis. We report the case of a 72-year-old female who was referred to our hospital for further investigation of anaemia, thrombocytopaenia, and leucocytosis and was diagnosed with MDS/MPN with neutrophilia. Bone marrow morphology exhibited hypercellular marrow with dysplastic features in all three lineages. Our case report and literature review offer valuable insights into the dynamics of the morphological features of MDS/MPN with neutrophilia. Malaysian Journal of Medicine and Health Sciences, UPM 2024-12 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/117924/1/117924.pdf Mohd Tohit, Eusni Rahayu and Nazar Shah, Norhanis and Khalid, Bahariah and Md Noor, Sabariah (2024) A case report of myelodysplastic and myeloproliferative neoplasms (MDS/MPN) with neutrophilia; an evidence of changes in their dynamics. Malaysian Journal of Medicine and Health Sciences, 20 (suppl.11). pp. 134-137. ISSN 1675-8544; eISSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2024123018574029_MJMHS_1040.pdf 10.47836/mjmhs20.s11.29 |
| spellingShingle | Mohd Tohit, Eusni Rahayu Nazar Shah, Norhanis Khalid, Bahariah Md Noor, Sabariah A case report of myelodysplastic and myeloproliferative neoplasms (MDS/MPN) with neutrophilia; an evidence of changes in their dynamics |
| title | A case report of myelodysplastic and myeloproliferative neoplasms (MDS/MPN) with neutrophilia; an evidence of changes in their dynamics |
| title_full | A case report of myelodysplastic and myeloproliferative neoplasms (MDS/MPN) with neutrophilia; an evidence of changes in their dynamics |
| title_fullStr | A case report of myelodysplastic and myeloproliferative neoplasms (MDS/MPN) with neutrophilia; an evidence of changes in their dynamics |
| title_full_unstemmed | A case report of myelodysplastic and myeloproliferative neoplasms (MDS/MPN) with neutrophilia; an evidence of changes in their dynamics |
| title_short | A case report of myelodysplastic and myeloproliferative neoplasms (MDS/MPN) with neutrophilia; an evidence of changes in their dynamics |
| title_sort | case report of myelodysplastic and myeloproliferative neoplasms (mds/mpn) with neutrophilia; an evidence of changes in their dynamics |
| url | http://psasir.upm.edu.my/id/eprint/117924/ http://psasir.upm.edu.my/id/eprint/117924/ http://psasir.upm.edu.my/id/eprint/117924/ http://psasir.upm.edu.my/id/eprint/117924/1/117924.pdf |