Targeting 8-oxoguanine DNA glycosylase-1 (OGG1) as a therapeutic strategy in inflammatory-related diseases

Targeting 8-oxoguanine DNA glycosylase-1 (OGG1) as a therapeutic strategy in inflammatory-related diseases

Inflammatory diseases are influenced by oxidative stress. Oxidatively damaged 8-oxoG in DNA is linked to inflammation. The enzyme OGG1 is responsible for repairing the damaged base in the DNA which is linked to pro-inflammatory signaling and severe inflammation. This study aims to explore the potent...

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Bibliographic Details
Main Authors: Samaila, Abdullahi, Basir, Rusliza, Gambo Lawal, Mukhtar, Abas, Razif, Abdullah, Maizaton Atmadini, Abd Majid, Roslaini, Nordin, Norshariza, Hussain, Mohd Khairi, Ab Razak, Nur Izah, Yoke Keong, Yong, Aliyu, Basiru
Format: Article
Language:English
Published: Taylor & Francis 2024
Online Access:http://psasir.upm.edu.my/id/eprint/117856/
http://psasir.upm.edu.my/id/eprint/117856/1/117856.pdf
Description
Summary:Inflammatory diseases are influenced by oxidative stress. Oxidatively damaged 8-oxoG in DNA is linked to inflammation. The enzyme OGG1 is responsible for repairing the damaged base in the DNA which is linked to pro-inflammatory signaling and severe inflammation. This study aims to explore the potential of targeting OGG1 as a therapeutic strategy in inflammatory disease conditions.

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