Deep eutectic solvents and natural deep eutectic solvents for extraction and purification of proteins from animal and botanical sources - a review
The rising global population has led to an escalating demand for affordable, high-quality proteins intended for human consumption. Different efforts have been made to develop efficient and greener solvents for protein production. Most proteins are produced from raw plant and animal parts, but the us...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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International Journal of Technology
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/117838/ http://psasir.upm.edu.my/id/eprint/117838/1/117838.pdf |
| _version_ | 1848867356817752064 |
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| author | Kumoro, Andri Cahyo Wardhani, Dyah Hesti Kusworo, Tutuk Djoko Djaeni, Mohamad Ping, Tan Chin Alhanif, Misbahudin |
| author_facet | Kumoro, Andri Cahyo Wardhani, Dyah Hesti Kusworo, Tutuk Djoko Djaeni, Mohamad Ping, Tan Chin Alhanif, Misbahudin |
| author_sort | Kumoro, Andri Cahyo |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The rising global population has led to an escalating demand for affordable, high-quality proteins intended for human consumption. Different efforts have been made to develop efficient and greener solvents for protein production. Most proteins are produced from raw plant and animal parts, but the use of the residues in commercial-scale protein production is very scarce. Therefore, this research aims to collect an overview of deep eutectic solvents (DESs) and natural deep eutectic solvents (NADESs) for protein extraction and purification. In this context, solvent type and operating parameters should also be selected to modify DESs and NADESs physicochemical characteristics for the achievement of high protein yield with preserved functional properties. The results show that appropriate implementation of combined DESs and NADESs with advanced extraction and purification techniques can improve protein yield and prevent detrimental effects on the extracted protein and environment. The application of DESs and NADESs can increase the efficiency of protein extraction and recovery in various parts of plants and animals by 55.72% and 98.16%, respectively, with purity reaching 99.82%. This research also reviews safety, environmental impacts, and drawbacks as well as shows feasible future recommendations for commercial-scale protein production processes. NADESs are safer than petroleum-based solvents but have higher toxicity than DESs. Magnetic adsorbent and magnetic solid-phase extraction methods have been shown to reduce labor-intensive steps, resulting in shorter operating times and superior protein recovery while maintaining functional properties. Meanwhile, protein producers' knowledge and motivation to use DES and NADES are strengthened. |
| first_indexed | 2025-11-15T14:35:12Z |
| format | Article |
| id | upm-117838 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:35:12Z |
| publishDate | 2024 |
| publisher | International Journal of Technology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1178382025-06-12T08:20:18Z http://psasir.upm.edu.my/id/eprint/117838/ Deep eutectic solvents and natural deep eutectic solvents for extraction and purification of proteins from animal and botanical sources - a review Kumoro, Andri Cahyo Wardhani, Dyah Hesti Kusworo, Tutuk Djoko Djaeni, Mohamad Ping, Tan Chin Alhanif, Misbahudin The rising global population has led to an escalating demand for affordable, high-quality proteins intended for human consumption. Different efforts have been made to develop efficient and greener solvents for protein production. Most proteins are produced from raw plant and animal parts, but the use of the residues in commercial-scale protein production is very scarce. Therefore, this research aims to collect an overview of deep eutectic solvents (DESs) and natural deep eutectic solvents (NADESs) for protein extraction and purification. In this context, solvent type and operating parameters should also be selected to modify DESs and NADESs physicochemical characteristics for the achievement of high protein yield with preserved functional properties. The results show that appropriate implementation of combined DESs and NADESs with advanced extraction and purification techniques can improve protein yield and prevent detrimental effects on the extracted protein and environment. The application of DESs and NADESs can increase the efficiency of protein extraction and recovery in various parts of plants and animals by 55.72% and 98.16%, respectively, with purity reaching 99.82%. This research also reviews safety, environmental impacts, and drawbacks as well as shows feasible future recommendations for commercial-scale protein production processes. NADESs are safer than petroleum-based solvents but have higher toxicity than DESs. Magnetic adsorbent and magnetic solid-phase extraction methods have been shown to reduce labor-intensive steps, resulting in shorter operating times and superior protein recovery while maintaining functional properties. Meanwhile, protein producers' knowledge and motivation to use DES and NADES are strengthened. International Journal of Technology 2024 Article PeerReviewed text en cc_by_nc_nd_4 http://psasir.upm.edu.my/id/eprint/117838/1/117838.pdf Kumoro, Andri Cahyo and Wardhani, Dyah Hesti and Kusworo, Tutuk Djoko and Djaeni, Mohamad and Ping, Tan Chin and Alhanif, Misbahudin (2024) Deep eutectic solvents and natural deep eutectic solvents for extraction and purification of proteins from animal and botanical sources - a review. International Journal of Technology, 15 (5). pp. 1420-1437. ISSN 2087-2100; eISSN: 2086-9614 https://ijtech.eng.ui.ac.id/article/view/6925 10.14716/ijtech.v15i5.6925 |
| spellingShingle | Kumoro, Andri Cahyo Wardhani, Dyah Hesti Kusworo, Tutuk Djoko Djaeni, Mohamad Ping, Tan Chin Alhanif, Misbahudin Deep eutectic solvents and natural deep eutectic solvents for extraction and purification of proteins from animal and botanical sources - a review |
| title | Deep eutectic solvents and natural deep eutectic solvents for extraction and purification of proteins from animal and botanical sources - a review |
| title_full | Deep eutectic solvents and natural deep eutectic solvents for extraction and purification of proteins from animal and botanical sources - a review |
| title_fullStr | Deep eutectic solvents and natural deep eutectic solvents for extraction and purification of proteins from animal and botanical sources - a review |
| title_full_unstemmed | Deep eutectic solvents and natural deep eutectic solvents for extraction and purification of proteins from animal and botanical sources - a review |
| title_short | Deep eutectic solvents and natural deep eutectic solvents for extraction and purification of proteins from animal and botanical sources - a review |
| title_sort | deep eutectic solvents and natural deep eutectic solvents for extraction and purification of proteins from animal and botanical sources - a review |
| url | http://psasir.upm.edu.my/id/eprint/117838/ http://psasir.upm.edu.my/id/eprint/117838/ http://psasir.upm.edu.my/id/eprint/117838/ http://psasir.upm.edu.my/id/eprint/117838/1/117838.pdf |