Acetylcholinesterase studies as colonic pseudo-obstruction inhibitor on quercitrin from neem leaf extract (Azadirachta indica)
This research focuses on the study of Acetylcholinesterase (AChE) as an inhibitor of Colonic PseudoObstruction using Quercitrin obtained from neem leaf extract (Azadirachta indica). The research methods used include Pymol, Pyrex, Protein Plus, and Lipinski's rule. Analysis using Pymol and Pyrex...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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LP2M Universitas Negeri Padang
2023
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| Online Access: | http://psasir.upm.edu.my/id/eprint/117715/ http://psasir.upm.edu.my/id/eprint/117715/1/117715.pdf |
| _version_ | 1848867321604472832 |
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| author | Abdul Ghani, Nur Hamizah Satriawan, Herland Yuhanda, Wismeri Roikhan, Muhammad Abdillah Rita, Rauza Sukma |
| author_facet | Abdul Ghani, Nur Hamizah Satriawan, Herland Yuhanda, Wismeri Roikhan, Muhammad Abdillah Rita, Rauza Sukma |
| author_sort | Abdul Ghani, Nur Hamizah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This research focuses on the study of Acetylcholinesterase (AChE) as an inhibitor of Colonic PseudoObstruction using Quercitrin obtained from neem leaf extract (Azadirachta indica). The research methods used include Pymol, Pyrex, Protein Plus, and Lipinski's rule. Analysis using Pymol and Pyrex resulted in Binding Affinity of -9.0, -8.8, and -8.7 and RMSD values of 0, 1.443, and 1.767 indicating a good potential interaction between AChE and Quercitrin. In this study, Protein Plus was used to identify the interaction between Quercitrin and AChE, the results showed a significant interaction between the two which may contribute in inhibiting Colonic Pseudo-Obstruction. Assessment of the physicochemical properties of Quercitrin using Lipinski's rule resulted in a molecular mass of 435, number of hydrogen bond donors 7, hydrogen bond acceptors 11, log P 0.000 and molar reactivity 0.000, indicating that Quercitrin meets the criteria to be an effective drug. Thus, the results of this study open up new prospects in the use of Quercitrin as a therapeutic agent in AChE inhibition for the treatment of Colonic Pseudo-Obstruction. |
| first_indexed | 2025-11-15T14:34:39Z |
| format | Article |
| id | upm-117715 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:34:39Z |
| publishDate | 2023 |
| publisher | LP2M Universitas Negeri Padang |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1177152025-06-10T23:50:36Z http://psasir.upm.edu.my/id/eprint/117715/ Acetylcholinesterase studies as colonic pseudo-obstruction inhibitor on quercitrin from neem leaf extract (Azadirachta indica) Abdul Ghani, Nur Hamizah Satriawan, Herland Yuhanda, Wismeri Roikhan, Muhammad Abdillah Rita, Rauza Sukma This research focuses on the study of Acetylcholinesterase (AChE) as an inhibitor of Colonic PseudoObstruction using Quercitrin obtained from neem leaf extract (Azadirachta indica). The research methods used include Pymol, Pyrex, Protein Plus, and Lipinski's rule. Analysis using Pymol and Pyrex resulted in Binding Affinity of -9.0, -8.8, and -8.7 and RMSD values of 0, 1.443, and 1.767 indicating a good potential interaction between AChE and Quercitrin. In this study, Protein Plus was used to identify the interaction between Quercitrin and AChE, the results showed a significant interaction between the two which may contribute in inhibiting Colonic Pseudo-Obstruction. Assessment of the physicochemical properties of Quercitrin using Lipinski's rule resulted in a molecular mass of 435, number of hydrogen bond donors 7, hydrogen bond acceptors 11, log P 0.000 and molar reactivity 0.000, indicating that Quercitrin meets the criteria to be an effective drug. Thus, the results of this study open up new prospects in the use of Quercitrin as a therapeutic agent in AChE inhibition for the treatment of Colonic Pseudo-Obstruction. LP2M Universitas Negeri Padang 2023 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/117715/1/117715.pdf Abdul Ghani, Nur Hamizah and Satriawan, Herland and Yuhanda, Wismeri and Roikhan, Muhammad Abdillah and Rita, Rauza Sukma (2023) Acetylcholinesterase studies as colonic pseudo-obstruction inhibitor on quercitrin from neem leaf extract (Azadirachta indica). Sainstek: International Journal on Applied Science, Advanced Technology and Informatics, 2 (2). pp. 64-71. ISSN 2776-1336; eISSN: 2776-1336 https://sainstek.ppj.unp.ac.id/index.php/sainstek/article/view/31 10.24036/sainstek/vol2-iss02/31 |
| spellingShingle | Abdul Ghani, Nur Hamizah Satriawan, Herland Yuhanda, Wismeri Roikhan, Muhammad Abdillah Rita, Rauza Sukma Acetylcholinesterase studies as colonic pseudo-obstruction inhibitor on quercitrin from neem leaf extract (Azadirachta indica) |
| title | Acetylcholinesterase studies as colonic pseudo-obstruction inhibitor on quercitrin from neem leaf extract (Azadirachta indica) |
| title_full | Acetylcholinesterase studies as colonic pseudo-obstruction inhibitor on quercitrin from neem leaf extract (Azadirachta indica) |
| title_fullStr | Acetylcholinesterase studies as colonic pseudo-obstruction inhibitor on quercitrin from neem leaf extract (Azadirachta indica) |
| title_full_unstemmed | Acetylcholinesterase studies as colonic pseudo-obstruction inhibitor on quercitrin from neem leaf extract (Azadirachta indica) |
| title_short | Acetylcholinesterase studies as colonic pseudo-obstruction inhibitor on quercitrin from neem leaf extract (Azadirachta indica) |
| title_sort | acetylcholinesterase studies as colonic pseudo-obstruction inhibitor on quercitrin from neem leaf extract (azadirachta indica) |
| url | http://psasir.upm.edu.my/id/eprint/117715/ http://psasir.upm.edu.my/id/eprint/117715/ http://psasir.upm.edu.my/id/eprint/117715/ http://psasir.upm.edu.my/id/eprint/117715/1/117715.pdf |