Screening techniques for drug discovery in Alzheimer's disease
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive and irreversible impairment of memory and other cognitive functions of the aging brain. Pathways such as amyloid beta neurotoxicity, tau pathogenesis and neuroinflammatory have been used to understand AD, despite n...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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American Chemical Society
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/117608/ http://psasir.upm.edu.my/id/eprint/117608/1/117608.pdf |
| _version_ | 1848867295101714432 |
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| author | Maniam, Sandra Maniam, Subashani |
| author_facet | Maniam, Sandra Maniam, Subashani |
| author_sort | Maniam, Sandra |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive and irreversible impairment of memory and other cognitive functions of the aging brain. Pathways such as amyloid beta neurotoxicity, tau pathogenesis and neuroinflammatory have been used to understand AD, despite not knowing the definite molecular mechanism which causes this progressive disease. This review attempts to summarize the small molecules that target these pathways using various techniques involving high-throughput screening, molecular modeling, custom bioassays, and spectroscopic detection tools. Novel and evolving screening methods developed to advance drug discovery initiatives in AD research are also highlighted. |
| first_indexed | 2025-11-15T14:34:13Z |
| format | Article |
| id | upm-117608 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:34:13Z |
| publishDate | 2024 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1176082025-05-30T06:35:44Z http://psasir.upm.edu.my/id/eprint/117608/ Screening techniques for drug discovery in Alzheimer's disease Maniam, Sandra Maniam, Subashani Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive and irreversible impairment of memory and other cognitive functions of the aging brain. Pathways such as amyloid beta neurotoxicity, tau pathogenesis and neuroinflammatory have been used to understand AD, despite not knowing the definite molecular mechanism which causes this progressive disease. This review attempts to summarize the small molecules that target these pathways using various techniques involving high-throughput screening, molecular modeling, custom bioassays, and spectroscopic detection tools. Novel and evolving screening methods developed to advance drug discovery initiatives in AD research are also highlighted. American Chemical Society 2024 Article PeerReviewed text en cc_by_nc_4 http://psasir.upm.edu.my/id/eprint/117608/1/117608.pdf Maniam, Sandra and Maniam, Subashani (2024) Screening techniques for drug discovery in Alzheimer's disease. ACS Omega, 9 (6). pp. 6059-6073. ISSN 2470-1343 https://pubs.acs.org/doi/10.1021/acsomega.3c07046 10.1021/acsomega.3c07046 |
| spellingShingle | Maniam, Sandra Maniam, Subashani Screening techniques for drug discovery in Alzheimer's disease |
| title | Screening techniques for drug discovery in Alzheimer's disease |
| title_full | Screening techniques for drug discovery in Alzheimer's disease |
| title_fullStr | Screening techniques for drug discovery in Alzheimer's disease |
| title_full_unstemmed | Screening techniques for drug discovery in Alzheimer's disease |
| title_short | Screening techniques for drug discovery in Alzheimer's disease |
| title_sort | screening techniques for drug discovery in alzheimer's disease |
| url | http://psasir.upm.edu.my/id/eprint/117608/ http://psasir.upm.edu.my/id/eprint/117608/ http://psasir.upm.edu.my/id/eprint/117608/ http://psasir.upm.edu.my/id/eprint/117608/1/117608.pdf |