Xanthine oxidase inhibitory activity by flavonoids from Chrysanthemum morifolium: in vitro and in silico insights
2-(3’,4’-dihydroxyphenyl)-3,6,7,8-tetramethoxy-4H-chromen-4-one (3), a new flavonoid was isolated from the ethyl acetate fraction of Chrysanthemum morifolium Ramat. dried flowers, while 4′,5-dihydroxy-3,3′,7,8-tetramethoxy-flavone (1) and casticine (5) were isolated from this plant for the first tim...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/117569/ http://psasir.upm.edu.my/id/eprint/117569/1/117569.pdf |
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| author | Tey, Zi Tong Loh, Khye Er Tan, Siow-Ping Yuan, Chongjun Tejo, Bimo Ario Ismail, Intan Safinar Nafiah, Mohd Azlan |
| author_facet | Tey, Zi Tong Loh, Khye Er Tan, Siow-Ping Yuan, Chongjun Tejo, Bimo Ario Ismail, Intan Safinar Nafiah, Mohd Azlan |
| author_sort | Tey, Zi Tong |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | 2-(3’,4’-dihydroxyphenyl)-3,6,7,8-tetramethoxy-4H-chromen-4-one (3), a new flavonoid was isolated from the ethyl acetate fraction of Chrysanthemum morifolium Ramat. dried flowers, while 4′,5-dihydroxy-3,3′,7,8-tetramethoxy-flavone (1) and casticine (5) were isolated from this plant for the first time, as well as two known flavonoids, eriodictyol-7-O-glucoside (2) and luteolin (4). Their structures were investigated over a broad spatial scale using chromatographic and spectroscopic techniques (NMR, FTIR, UV and HR-ESI-MS). Compound 4 showed the highest XO inhibition and the most favorable interaction with XO in molecular docking analysis. Compound 2, 3 and 4 demonstrated stable interactions with catalytically important residues in xanthine oxidase via molecular dynamic analysis. |
| first_indexed | 2025-11-15T14:34:04Z |
| format | Article |
| id | upm-117569 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:34:04Z |
| publishDate | 2024 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1175692025-07-09T08:43:24Z http://psasir.upm.edu.my/id/eprint/117569/ Xanthine oxidase inhibitory activity by flavonoids from Chrysanthemum morifolium: in vitro and in silico insights Tey, Zi Tong Loh, Khye Er Tan, Siow-Ping Yuan, Chongjun Tejo, Bimo Ario Ismail, Intan Safinar Nafiah, Mohd Azlan 2-(3’,4’-dihydroxyphenyl)-3,6,7,8-tetramethoxy-4H-chromen-4-one (3), a new flavonoid was isolated from the ethyl acetate fraction of Chrysanthemum morifolium Ramat. dried flowers, while 4′,5-dihydroxy-3,3′,7,8-tetramethoxy-flavone (1) and casticine (5) were isolated from this plant for the first time, as well as two known flavonoids, eriodictyol-7-O-glucoside (2) and luteolin (4). Their structures were investigated over a broad spatial scale using chromatographic and spectroscopic techniques (NMR, FTIR, UV and HR-ESI-MS). Compound 4 showed the highest XO inhibition and the most favorable interaction with XO in molecular docking analysis. Compound 2, 3 and 4 demonstrated stable interactions with catalytically important residues in xanthine oxidase via molecular dynamic analysis. Elsevier 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/117569/1/117569.pdf Tey, Zi Tong and Loh, Khye Er and Tan, Siow-Ping and Yuan, Chongjun and Tejo, Bimo Ario and Ismail, Intan Safinar and Nafiah, Mohd Azlan (2024) Xanthine oxidase inhibitory activity by flavonoids from Chrysanthemum morifolium: in vitro and in silico insights. Phytochemistry Letters, 64. pp. 68-78. ISSN 1874-3900 https://linkinghub.elsevier.com/retrieve/pii/S1874390024001393 10.1016/j.phytol.2024.10.002 |
| spellingShingle | Tey, Zi Tong Loh, Khye Er Tan, Siow-Ping Yuan, Chongjun Tejo, Bimo Ario Ismail, Intan Safinar Nafiah, Mohd Azlan Xanthine oxidase inhibitory activity by flavonoids from Chrysanthemum morifolium: in vitro and in silico insights |
| title | Xanthine oxidase inhibitory activity by flavonoids from Chrysanthemum morifolium: in vitro and in silico insights |
| title_full | Xanthine oxidase inhibitory activity by flavonoids from Chrysanthemum morifolium: in vitro and in silico insights |
| title_fullStr | Xanthine oxidase inhibitory activity by flavonoids from Chrysanthemum morifolium: in vitro and in silico insights |
| title_full_unstemmed | Xanthine oxidase inhibitory activity by flavonoids from Chrysanthemum morifolium: in vitro and in silico insights |
| title_short | Xanthine oxidase inhibitory activity by flavonoids from Chrysanthemum morifolium: in vitro and in silico insights |
| title_sort | xanthine oxidase inhibitory activity by flavonoids from chrysanthemum morifolium: in vitro and in silico insights |
| url | http://psasir.upm.edu.my/id/eprint/117569/ http://psasir.upm.edu.my/id/eprint/117569/ http://psasir.upm.edu.my/id/eprint/117569/ http://psasir.upm.edu.my/id/eprint/117569/1/117569.pdf |